A5008284974- Dietary Effects on Health
- Autophagy in Disease and Therapy
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Abdominal Trauma and Injuries
- Fatty Acid Research and Health
- Hydrogen's biological and therapeutic effects
- Acute Lymphoblastic Leukemia research
- Hemoglobin structure and function
- Phagocytosis and Immune Regulation
- Hippo pathway signaling and YAP/TAZ
- Lymphatic System and Diseases
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Tryptophan and brain disorders
- Vagus Nerve Stimulation Research
- Apelin-related biomedical research
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Ziziphus Jujuba Studies and Applications
- Advanced Glycation End Products research
- Respiratory Support and Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Hebei North University
2019-2025
Peking University
2025
Peking University Third Hospital
2025
North Minzu University
2025
Shanghai University of Medicine and Health Sciences
2024
Jiading District Central Hospital
2021-2024
Community Health Center
2024
Shanghai Jiao Tong University
2024
University of Iowa
2022
ABSTRACT Objective Lymphatic vessels and blood have some similarities in structure, but they distinct contraction characteristics functions. Revealing the detailed transcriptional differences of lymphatic, artery vein are required for circulation research. Methods The tissues mesenteric artery, were collected from Wistar rats. transcriptome signatures these RNA‐seq (RNA sequencing) analyzed using bioinformatic methods. Results GO (gene ontology) enrichment showed three gene expression...
DNA methylation is one of the earliest and most extensively studied epigenetic regulatory mechanisms. The ROS1 (Repressor Silencing 1) gene was first discovered in Arabidopsis thaliana, it a demethylase that can remove 5-methylcytosine from DNA, thereby affecting levels expression. Objectives: objective this study to investigate role development maturation Ziziphus jujuba cv. "Dongzao" fruit. Methods: We cloned conducted bioinformatics expression characteristics analyses on it. Results:...
Abstract Depression is a serious psychiatric illness that causes great inconvenience to the lives of elderly individuals. However, diagnosis depression somewhat subjective. Nontargeted gas chromatography (GC)/liquid (LC)–mass spectrometry (MS) was used study plasma metabolic profile and identify objective markers for pathway variation. We recruited 379 Chinese community-dwelling individuals aged ≥ 65. Plasma samples were collected detected by GC/LC‒MS. Orthogonal partial least squares...
Autonomic nervous system (ANS) disorders may occur in skeletal muscle disease, but the link between them has not been fully established. Studying relationship yield insights into mechanisms and treatment of disease. This study aimed to explore association heart rate variability (HRV), sarcopenia, subscales sarcopenia (muscle mass, strength, physical mobility). 2514 community-dwelling older Chinese participants were included this study. The Asian Working Group for Sarcopenia guidelines used...
Background: The COVID-19 pandemic is a significant health threat. Health care worker (HCWs) are at risk of infection which may cause high levels psychological distress. aim this study was to investigate the impact on HCWs and factors were associated with these stresses during first outbreak in Shanghai. Methods: Between February 9 21, 2020, total 3,114 frontline from 26 hospitals Shanghai completed an online survey. questionnaire included questions their sociodemographic characteristics, 15...
Vascular hypo-reactivity plays a critical role inducing organ injury during hemorrhagic shock. 17β-estradiol (E2) can induce vasodilation to increase blood flow in various vascular beds. This study observed whether E2 restore induced by shock, and effects are associated with RhoA-Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway. The shock model (40 ± 2 mm Hg for 1 h, resuscitation 4 h) was established ovary intact sham operation (OVI), ovariectomized (OVX), OVX plus supplement...
To investigate the effect of mesenteric lymph drainage on spleen injury and expressions inflammatory cytokines in splenic tissue mice following hemorrhagic shock.Male C57 were randomly divided into sham shock, shock shock+drainage groups. The both groups suffered femoral artery bleeding, maintained mean arterial pressure (MAP) 40±2 mmHg for 90 min, resuscitated. And was performed group at time resuscitation. After three hours resuscitation, tissues harvested histological observation protein...
The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that can be obtained quickly, conveniently, and cheaply from blood samples. However, there no research to explore the effects sex age on relationship between NLR mild cognitive impairment (MCI) in community-dwelling older adults.A total 3,126 individuals aged over 60 years Shanghai were recruited for face-to-face interviews, samples collected. MCI was assessed by Mini-Mental State Examination (MMSE) Instrumental Activities...
Abstract Context Advanced glycation end products (AGEs) are a group of molecules formed through nonenzymatic reactions. These compounds associated with several age-related diseases, including sarcopenia and osteoporosis. Objective This work aimed to investigate the relationships between AGEs, osteoporosis, in community-dwelling older adults. Methods cross-sectional study included 1991 adults aged 72.37 ± 5.90 years from China. AGE levels were measured by Reader device. Bone mineral density...
Purpose Post hemorrhagic shock mesenteric lymph (PHSML) return contributes to CD4 + T cell dysfunction, which leads immune dysfunction and uncontrolled inflammatory response. Tumor necrosis factor α induced protein 8 like-2 (TIPE2) is one of the essential proteins maintain homeostasis. This study investigated role TIPE2 in regulation lymphocyte function interaction PHSML TLR2/TLR4. Methods The splenic cells were isolated from various mice (WT, TLR2 -/- , TLR4 ) by immunomagnetic beads,...
Objective: The aim of this study was to clarify the role autophagy in stellate ganglion block (SGB) reversing posthemorrhagic shock mesenteric lymph (PHSML)-mediated vascular hyporeactivity. Methods: Hemorrhagic model conscious rats employed observe effects SGB (0.2 ml 0.25% ropivacaine hydrochloride hydrate) and inhibitor 3-methyladenine (3-MA; 30 mg/kg) on reactivity second-order rat arteries vitro , while PHSML (1 ml/kg) agonist rapamycin (Rapa, 10 beneficial effect were investigated....
Background and aims: Emerging studies indicate that time-restricted eating (TRE) may protect against cardiovascular disease (CVD); however, performed in elderly adults are limited.This study aimed to analyze the association of TRE with arterial stiffness (AS) community-dwelling Chinese individuals.Methods results: This cross-sectional recruited 3487 participants aged ≥ 60 y from Shanghai, China.TRE was determined by calculating end time last meal minus start first average day.Participants...
<title>Abstract</title> <bold>Background: </bold>Mild cognitive impairment (MCI) and depression are prominent public health concerns among older adults, closely linked to their nutritional status. Our study aimed explore the association mediation pathways involving depression, status, MCI in this population. <bold>Methods:</bold> The included 4799 community-dwelling Chinese adults aged 60 years Tianjin Shanghai, China. We utilized 30-item Geriatric Depression Scale (GDS-30) assess presence...
Hemorrhagic shock is associated with activation of renin-angiotensin system (RAS) and endoplasmic reticulum stress (ERS). Previous studies demonstrated that central RAS produced by various challenges sensitizes angiotensin (Ang) II-elicited hypertension ERS contributes to the development neurogenic hypertension. The present study investigated whether controlled hemorrhage could sensitize Ang brain mediate this sensitization. Results showed hemorrhaged (HEM) rats had a significantly enhanced...
Severe hemorrhage-induced acute lung injury (ALI) remains the major contributor to critical patient mortality and is associated with posthemorrhagic shock mesenteric lymph (PHSML) return. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) play overall protection on hemorrhage, but a reliable mechanism needs be identified. The aims of this study were investigate role ω-3 PUFAs in alleviating ALI whether related endotoxin contained PHSML. Mesenteric was harvested from rats subjected hemorrhagic...
Abstract Background Intestinal barrier dysfunction is the critical link of distant organ injury caused by hemorrhagic shock. The role autophagy in ischemic intestinal has been paid more and attention. Prophylactic treatment stellate ganglion block (SGB) reduces induced haemorrhagic This study investigated SGB post-processing on improved bowel function autophagy-related mechanisms action after Methods model shock conscious rats was established, were treated with SGB, inhibitor 3-...