A5068603369- Layered Double Hydroxides Synthesis and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- COVID-19 and Mental Health
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Photodynamic Therapy Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Magnesium Oxide Properties and Applications
- Nanocluster Synthesis and Applications
- COVID-19 and healthcare impacts
- Asthma and respiratory diseases
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Photocatalysis Techniques
- Plant-derived Lignans Synthesis and Bioactivity
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
- Heme Oxygenase-1 and Carbon Monoxide
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Plant Pathogenic Bacteria Studies
- Long-Term Effects of COVID-19
- Infection Control and Ventilation
Shanghai University of Traditional Chinese Medicine
2018-2024
Shuguang Hospital
2018-2023
State Council of the People's Republic of China
2018
Abstract: Curcumin (Cur) is a promising photosensitizer that could be used in photodynamic therapy. However, its poor solubility and hydrolytic instability limit clinical use. The aim of the present study was to encapsulate Cur into solid lipid nanoparticles (SLNs) order improve therapeutic activity. Cur-loaded SLNs (Cur-SLNs) were prepared using an emulsification low-temperature solidification method. functions Cur-SLNs studied on non-small cell lung cancer A549 cells for results revealed...
SummaryBackgroundThe outbreak of COVID-19 has led to international concern. We aimed establish an effective screening strategy in Shanghai, China, aid early identification patients with COVID-19.MethodsWe did a multicentre, observational cohort study fever clinics 25 hospitals 16 districts Shanghai. All visiting the within period were included. A for was presented and then suspected cases monitored analysed until they confirmed as or excluded. Logistic regression used determine risk factors...
Tumor-associated macrophages (TAMs) are important immune cells in the tumor microenvironment (TME). The polar plasticity of TAMs makes them targets for improving immunosuppressive tumors. previous study reveals that layered double hydroxides (LDHs) can effectively promote polarization from anti-inflammatory M2 type to pro-inflammatory M1 type. However, their mechanisms action remain unexplored. This LDHs composed different cations exhibit distinct abilities regulate polarity TAMs. Compared...
The discovery of a potent photosensitizer with desirable immunogenic cell death (ICD) ability can prominently enhance antitumor immunity in photodynamic therapy (PDT). However, majority commercially-available photosensitizers suffer from serious aggregation and fail to elicit sufficient ICD. Pyroptosis as newly identified pattern for ICD generation is rarely disclosed reported photosensitizers. In addition, the excellent mitochondria-anchored evokes prominent mitochondria oxidative stress,...
LDH-VP16 sensitizes GSCs and attenuates pluripotency gene expression, hence exhibits targeting capability, eliminates glioma at the prime state.
Currently, nanoparticles have gained a great attention in the anti-tumor research area. However, to date, studies on anti-metastasis action of core-shell SiO
Inefficient differentiation and poor engraftment hinder the clinical applications of mesenchymal stem cell (MSC)-based therapies in regenerative medicine. Layered double hydroxide (LDH) nanoparticles are sheet-like materials with desirable biocompatibility anion-exchange properties have been widely applied as drug nucleotide carriers field tissue repair. However, few studies focused on biological effects LDH itself. In this study, we demonstrated novel function stimulating osteogenic bone...
Abstract The tumor immune microenvironment (TIME) has been demonstrated to be the main cause of cancer immunotherapy failure in various malignant tumors, due poor immunogenicity and existence immunosuppressive factors. Thus, establishing effective treatments for hostile TIME remodeling considerable potential enhance response rates durable growth retardation. This study aims develop a novel nanocomposite, polyethyleneimine-modified dendritic mesoporous silica nanoparticles loaded with...
The aim of this study was to investigate the expression FGF2 and FGFR2 in patients with idiopathic pulmonary fibrosis (IPF) lung cancer (LC) as well their clinical significance. Reverse transcription-quantitative PCR (RT-qPCR) western blotting were used detect LC adjacent normal tissues lavage fluid fibers controls (confirmed by bronchoalveolar examination). levels mRNA protein non-small cell significantly higher than those (P<0.001). level IPF that control group not correlated age, sex...
Abstract Visualization technology has become a trend in tumor therapy recent years. The superior optical properties of graphene quantum dots (GQDs) make them suitable candidates for diagnosis, but their targeting and drug‐carrying capacities are still not ideal treatment. Sulfur‐doped (SGQDs) with stable fluorescence prepared previous study. A reliable strategy by associating layered double hydroxides (LDHs) etoposide (VP16) is designed precise visualization therapy. Trifunctional...
Schematic diagram showing the intercalation of Dexa into MgAl–LDH interlayers.
Carbon dots (CDs) hold great promise as a class of fluorophores for bioimaging. Here, we report simple solvothermal approach to prepare photoluminescent CDs derived from the antineoplastic drug etoposide. The show photoluminescence ranging 365 650 nm when excited at 360 nm. When 405, 488 and 543 nm, strong blue, green red fluorescence can be detected. Our experiments reveal that penetrate into cells in short time remain emissive, even low temperature. Also, optical signals detected mice...
Abstract Herein, we found that serum chemokine ligand 14 (CXCL14) was significantly enhanced in patients with idiopathic pulmonary fibrosis (IPF). In our current study, mouse L929 fibroblasts were stimulated lipopolysaccharide (LPS) (100 ng/mL). Cell proliferation, the levels of matrix metalloproteinase 2 (MMP2) and MMP9, as well extracellular (ECM) content assessed to evaluate fibrogenesis cells. Proliferating cell nuclear antigen viability proliferation. Hydroxyproline (Hyp), collagen...
Pulmonary fibrosis (PF) is a heterogeneous pathological process in lung tissues with considerable mortality rate. Currently, combination therapy represents an effective approach to treat PF. Dexamethasone (Dxs) and berberine (BBR) are widely applied inhibit the progression of Dxs plus penehyclidine hydrochloride or alfacalcidol have been reported more compared any single drug treatment. However, whether BBR induces increased antifibrotic effect remains unknown. The current study aimed...
Background: The COVID-19 pandemic is a significant health threat. Health care worker (HCWs) are at risk of infection which may cause high levels psychological distress. aim this study was to investigate the impact on HCWs and factors were associated with these stresses during first outbreak in Shanghai. Methods: Between February 9 21, 2020, total 3,114 frontline from 26 hospitals Shanghai completed an online survey. questionnaire included questions their sociodemographic characteristics, 15...
Abstract Inflammatory bowel disease (IBD) is a chronic and destructive autoimmune that has created global burden. However, the pathogenesis treatment strategies of IBD remain difficult problems to overcome. The anti‐inflammatory action anion‐dependent layered double hydroxide (LDH) evaluated in IBD. Raw264.7 macrophages induced by Lipopolysaccharide (LPS) produced low levels pro‐inflammatory cytokines after LDH treatment. results from dextran sulfate sodium (DSS)‐induced murine colitis...
To investigate the gene-expression profile of chronic obstructive pulmonary disease (COPD) patients and explore possible therapeutic targets.The microarray raw dataset GSE29133, including three COPD samples normal samples, was obtained from Gene Expression Omnibus. After data preprocessing with Affy package, Student's t-test employed to identify differentially expressed genes (DEGs). The up- downregulated DEGs were then pooled for gene-ontology pathway-enrichment analyses using Database...
Background Chronic obstructive pulmonary disease (COPD) has a high fatality rate and poses great threat to human health. Astragaloside IV (AS-IV) is proven attenuate cigarette smoke (CS)-induced inflammation, based on which this research focuses the mechanism of AS-IV in COPD.Methods To evaluate effects AS-IV, CD4+ T cells received different concentrations AS-IV. cell viability, helper 17 (Th17)/regulatory (Treg) markers CXCR4 expressions or spleen/lung tissues were detected by...
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects FZHYR on pulmonary fibrosis and macrophage polarization were investigated
Cell migration and invasion are integral to lung cancer metastasis. In this study, we investigated the combination of traditional chemotherapy a layered double hydroxide (LDH) carrier as new strategy for inhibition invasion. To investigate characteristics possible mechanisms VP16-LDH [the Mg-Al/LDH containing etoposide (VP16)], used several experimental techniques, such transmission electron microscopy (TEM) fluorescent microscopy. The TEM, X-ray diffraction (XRD) zeta potential results...