Inspired by fireworks explosion at night, conventional algorithm (FWA) was developed in 2010. Since then, several improvements and applications were proposed to improve the efficiency of FWA. In this paper, is first summarized three improved algorithms are provided. By changing ways calculating numbers amplitudes sparks fireworks' explosion, FWA become more reasonable explainable. addition, multi-objective graphic processing unit (GPU) based also presented, particularly GPU able speed up...

Transcribing and replicating a double-stranded genome require protein modules to unwind, transcribe/replicate nucleic acid substrates, release products. Here we present in situ cryo-electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) two states pertaining transcription. In addition the previously discovered universal "hand-shaped" core domain shared by DNA polymerases telomerases, our results show function N- C-terminal domains RdRp: former opens duplex isolate...

Abstract The purpose of this study was to investigate the causal association between unhealthy lifestyle style factors and risk colorectal cancer, with aim preventing occurrence cancer by modifying lifestyles. A two-sample Mendelian randomization (MR) approach employed in study, utilizing inverse-variance weighted method as primary research method. This MR analysis analyzed data 3022 cases 174,006 controls from FinnGen database. Single nucleotide polymorphisms (SNPs) associated were selected...

Swarm intelligence algorithms have been widely used to solve difficult real world problems in both academic and engineering domains. Thanks the inherent parallelism, various parallelized swarm proposed speed up optimization process, especially on massively parallel processing architecture GPUs. However, conventional are usually not designed specifically for GPU architecture.They neither can fully exploit tremendous computational power of GPUs nor extend effectively as problem scales go...

The recent success in ribosome structure determination by cryoEM has opened the door to defining structural differences between ribosomes of pathogenic organisms and humans understand ribosome-targeting antibiotics. Here, direct electron-counting cryoEM, we have determined structures Leishmania donovani human at 2.9 Å 3.6 Å, respectively. Our leishmanial elucidates organization six fragments its large subunit rRNA (as opposed a single 28S most eukaryotes, including humans) reveals atomic...

Bluetongue virus (BTV), a major threat to livestock, is multilayered, nonturreted member of the Reoviridae , family segmented dsRNA viruses characterized by endogenous RNA transcription through an RNA-dependent polymerase (RdRp). To date, structure BTV RdRp has been unknown, limiting our mechanistic understanding and hindering rational drug design effort targeting this essential enzyme. Here, we report in situ structures VP1 both triple-layered virion double-layered core, as determined...

We consider how to cover the most area inside of a circular disc by using finitely many triangles. Even in simple cases with number triangles being small, we do not know what is maximum that can be covered. However, as tends infinity, use some estimates and existing literature derive rate uncovered goes zero.

ABSTRACT Peste des petits ruminants virus (PPRV) is an important pathogen that has long been a significant threat to small ruminant productivity worldwide. Iron metabolism vital the host and pathogen. However, mechanism underlying host-PPRV interactions from perspective of iron iron-mediated membrane lipid peroxidation not reported thus far. In this study, we identified novel long-noncoding RNA (lncRNA), APR, impairs PPRV infectivity by sponging miR-3955-5p, negative microRNA (miRNA)...

This study systematically simulates and analyzes the dynamic response of a thin plate structure under different damage conditions based on transient model, aiming to evaluate performance Wave Atom transform, wavelet packet Curvelet transform in detection. By applying random initial displacement excitations using optimized load step settings, impact severities, ranges, boundary damage, spacing is analyzed. The results show that both transforms can effectively identify precise location large...

Viruses in the family Reoviridae are characterized by ability to endogenously synthesize nascent RNA within virus. However, mechanisms for assembling their genomes with transcriptional enzymes into a multilayered virion and priming such transcription poorly understood. By cryo-EM novel asymmetric reconstruction, we determined atomic structure of complex inside aquareoviruses (ARV) that primed infection. The is anchored N-terminal segments enclosing capsid proteins contains an NTPase...

With the popularity of cloud computing, information security issues in environment are becoming more and prominent. As first line defense to ensure computing security, user authentication has attracted extensive attention. Though considerable efforts have been paid for a secure practical scheme environment, most attempts ended failure. The design efficient remains challenge on one hand user’s smart card or mobile devices limited resource; other hand, with combination Internet Things,...

Abstract Objective Tumor immune infiltration leads to poor prognosis of gastric cancer patients and seriously affects the life quality patients. This study was based on bioinformatics screen prognostic biomarkers in with high degree invasion cancer. Meanwhile, action biomarker CCDC80 explored by cell tumorigenesis experiments, provide reference for cure Methods Data sets clinical massage were collected from TCGA database GEO database. ConsensusClusterPlus used cluster 28 cells ssGSEA. R...

Intelligent optimization algorithms are very effective to tackle complex problems that would be difficult or impossible solve exactly. A key component within these is the random number generators (RNGs) which provide numbers drive stochastic search process. Much effort devoted develop efficient RNGs with good statistical properties, and many highly optimized libraries ready use for generating fast on both CPUs other hardware platforms such as GPUs. However, few study focused how different...

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation a novel class gold nanoshells with cores composed self-assembled block copolypeptide vesicles properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) coated thin layer demonstrate enhanced absorption light due to surface plasmon resonance (SPR) in near-infrared range. show that polypeptide-based K60L20...

Inversion is a critical and challenging task in geophysical research. Geophysical inversion can be formulated as an optimization problem to find the best parameters whose forward synthesis data most fit observed data. The inverse problems are usually highly non-linear, multi-modal well ill-posed, so conventional algorithms cannot handle it very efficiently. In past decades, genetic algorithm (GA) its many variants widely applied achieve great success. Swarm intelligence family of global...

Currently, there is no curative treatment for advanced metastatic prostate cancer, and options, such as chemotherapy, are often nonspecific, harming healthy cells resulting in severe side effects. Attaching targeting ligands to agents used anticancer therapies has been shown improve efficacy reduce nonspecific toxicity. Furthermore, the use of triggered can enable spatial temporal control over treatment. Here, we combined an engineered cancer-specific ligand, A11 minibody, with a novel...

This work aims to investigate dental root filling custom gutta-percha (GP) properties based on melt extrusion 3D printing for periapical periodontal disease treatment. Zinc oxide nanoparticles are incorporated into polyurethane/gutta-percha (PGB) composites. A polyurethane/gutta-percha/ZnO (PGB-Zn) biocomposite including BaSO4, polyurethane (PU), GP, and ZnO is designed fabricated. To improve the dispersion of nanoparticles, rosin chosen modify surface nanoparticles. The PGB-Zn exhibits a...

Fireworks Algorithm (FWA) is a recently developed Swarm Intelligence (SIA), which has been successfully used in diverse domains. When applied to complicated problems, many function evaluations are needed obtain an acceptable solution. To address this critical issue, GPU-based variant (GPU-FWA) was proposed greatly accelerate the optimization procedure of FWA. Thanks active studies on FWA and GPU computing, advances have achieved since GPU-FWA. In paper, novel variant, Attract-Repulse...