A5100735819- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Computational Physics and Python Applications
- Cosmology and Gravitation Theories
- Neutrino Physics Research
- Black Holes and Theoretical Physics
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Nuclear physics research studies
- Viral Infections and Vectors
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- advanced mathematical theories
- Enzyme Structure and Function
- Astrophysics and Cosmic Phenomena
- Prion Diseases and Protein Misfolding
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Particle Accelerators and Free-Electron Lasers
- RNA Research and Splicing
- Viral Infections and Outbreaks Research
- Advanced Electron Microscopy Techniques and Applications
Wuhan University
2020-2025
Henan Normal University
2024-2025
First Affiliated Hospital of Dalian Medical University
2025
Dalian Medical University
2025
University of California, Los Angeles
2013-2024
Institute of High Energy Physics
2014-2024
Inner Mongolia University
2023
Henan University
2023
Xiamen University
2023
Nanjing University
2014-2023
α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and vivo seeding activities, contributing differently to synucleinopathies. Despite numerous prior attempts, how polymorphic aSyn fibrils differ atomic structure remains elusive. Here, we present fibril from the full-length recombinant human their capacity cytotoxicity vitro. By cryo-electron microscopy helical reconstruction, determine structures of two predominant species, a rod twister, both at 3.7 Å resolution. Our models...
Abstract Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated with aggregation protein tau into fibrils. Thus disaggregation fibrils could be a therapeutic approach to AD. The small molecule EGCG, abundant in green tea, has long been known disaggregate other amyloid fibrils, but EGCG poor drug-like properties, failing fully penetrate brain. Here we have cryogenically trapped an intermediate brain-extracted on kinetic pathway EGCG-induced determined its...
Vesicular stomatitis virus (VSV) is a bullet-shaped rhabdovirus and model system of negative-strand RNA viruses. Through direct visualization by means cryo-electron microscopy, we show that each virion contains two nested, left-handed helices: an outer helix matrix protein M inner nucleoprotein N RNA. has hub domain with four contact sites link to neighboring subunits, providing rigidity clamping adjacent turns the nucleocapsid. Side-by-side interactions between subunits are critical for...
Helical assemblies such as filamentous viruses, flagella, and F-actin represent an important category of structures in biology. As the first discovered virus, tobacco mosaic virus (TMV) was at center research. Previously, structure TMV solved atomic detail by X-ray fiber diffraction but only for its dormant or high-calcium-concentration state, not low-calcium-concentration which is relevant to viral assembly disassembly inside host cells. Here we report a helical reconstruction calcium-free,...
Actin filament assembly and disassembly are vital for cell functions. MICAL Redox enzymes important post-translational effectors of actin that stereo-specifically oxidize actin's M44 M47 residues to induce cellular F-actin disassembly. Here we show Mical-oxidized (Mox) can undergo extremely fast (84 subunits/s) disassembly, which depends on F-actin's nucleotide-bound state. Using near-atomic resolution cryoEM reconstruction single TIRF microscopy identify two dynamic structural states...
Abstract Using inclusive decays of , a precise determination the number events collected with BESIII detector was performed. For two data sets taken in 2009 and 2012, numbers were recalculated to be respectively; these are good agreement previous measurements. sample 2017–2019, determined . The total where uncertainty is dominated by systematic effects, statistical negligible.
Based on 10 billion J/ψ events collected at the BESIII experiment, a search for CP violation in Λ decay is performed difference between CP-odd parameters α_{-} Λ→pπ^{-} and α_{+} Λ[over ¯]→p[over ¯]π^{+} by using process e^{+}e^{-}→J/ψ→ΛΛ[over ¯]. With five-dimensional fit to full angular distributions of daughter baryon, most precise values are determined be α_{-}=0.7519±0.0036±0.0024 α_{+}=-0.7559±0.0036±0.0030, respectively. The ¯] averaged value parameter extracted...
Based on a sample of (10.09$\pm$0.04)$\times$10$^{9}$ $J/\psi$ events collected with the BESIII detector operating at BEPCII storage ring, partial wave analysis decay $J/\psi \rightarrow \gamma\eta\eta'$ is performed. An isoscalar state exotic quantum numbers $J^{PC}=1^{-+}$, denoted as $\eta_1(1855)$, has been observed for first time statistical significance larger than 19$\sigma$. Its mass and width are measured to be (1855$\pm$9$_{-1}^{+6}$)~MeV/$c^{2}$ (188$\pm$18$_{-8}^{+3}$)~MeV,...
Based on a data sample of <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mo stretchy="false">(</a:mo><a:mn>2712.4</a:mn><a:mo>±</a:mo><a:mn>14.3</a:mn><a:mo stretchy="false">)</a:mo><a:mo>×</a:mo><a:msup><a:mn>10</a:mn><a:mn>6</a:mn></a:msup><a:mi>ψ</a:mi><a:mo stretchy="false">(</a:mo><a:mn>3686</a:mn><a:mo stretchy="false">)</a:mo></a:math> events collected with the BESIII detector at BEPCII collider, M1 transition <g:math...