A5011755184- Magnetic Bearings and Levitation Dynamics
- Electric Motor Design and Analysis
- Tribology and Lubrication Engineering
- Alzheimer's disease research and treatments
- Sensorless Control of Electric Motors
- Supramolecular Self-Assembly in Materials
- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Protein Structure and Dynamics
- Ferroptosis and cancer prognosis
- Silicon Carbide Semiconductor Technologies
- Vibration and Dynamic Analysis
- Green IT and Sustainability
- Advanced Algorithms and Applications
- Laser and Thermal Forming Techniques
- Parallel Computing and Optimization Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Simulation and Modeling Applications
- Curcumin's Biomedical Applications
- Acoustic Wave Phenomena Research
- Iterative Learning Control Systems
- Redox biology and oxidative stress
- Ferroelectric and Negative Capacitance Devices
- Advanced Nanomaterials in Catalysis
- Amino Acid Enzymes and Metabolism
Xuzhou University of Technology
2023-2025
Southern Medical University
2024
Guangdong Provincial People's Hospital
2023-2024
Jiangsu University
2020-2023
Chinese Academy of Sciences
2016-2021
Institute of Hydrobiology
2016-2021
Harbin Engineering University
2019
Washington University in St. Louis
2018
Peking University
2005-2013
Clark University
2009-2012
Introduction: Photodynamic therapy (PDT) and photothermal (PTT) are widely used in the treatment of tumors. However, their application clinical tumors is limited by complexity irreversible hypoxia environment generated tumor tissues. To overcome this limitation, a nanoparticle composed indocyanine green (ICG) Fe-MOF-5 was developed. Methods: We prepared F-I@FM5 measured its morphology, particle size, stability. Its enzyme like ability optical effect verified. Then we MTT, staining flow...
The pathologic self-assembly of proteins is associated with typically late-onset disorders such as Alzheimer's disease, Parkinson's and type 2 diabetes. Important mechanistic details the are unknown, but there increasing evidence supporting role transient α-helices in early events. Islet amyloid polypeptide (IAPP) a 37-residue that self-assembles into aggregates toxic to insulin-producing β cells. To elucidate events IAPP, we used limited proteolysis identify an exposed flexible region IAPP...
Abstract Calcium (Ca 2+ ) and redox signalling play important roles in acclimation processes from archaea to eukaryotic organisms. Herein we characterized a unique protein Chlamydomonas reinhardtii that has the competence integrate Ca - redox-related signalling. This protein, designated as calredoxin (CRX), combines four -binding EF-hands thioredoxin (TRX) domain. A crystal structure of CRX, at 1.6 Å resolution, revealed an unusual calmodulin-fold EF-hands, which is functionally linked via...
The interaction of small molecules with the surface amyloid assemblies is important for detection and inhibition formation. Thioflavin T (ThT), a molecular rotor, has been used fibrils over half century. basis simple in that presence fluorescence ThT dramatically enhanced. mechanism this enhancement not well understood but may depend on determination conformation bound to fibril surface. Here, we first use solution-state (1)H NMR show on-off binding insulin correlates fluorescence. We then...
Modern mobile applications have grown rapidly in binary size, which restricts user growth and hinders updates for existing users. Thus, reducing the size is important application developers. Recent studies shown possibility of using link-time code optimizations by re-invoking certain compiler on linked intermediate representation program. However, such methods often incur significant build time overhead require intrusive changes to pipeline.
Thioflavin T (ThT) is used widely for the detection of amyloid fibrils. Detection based on dramatic enhancement its fluorescence following binding to The biophysical basis this effect remains poorly understood but may lie in elucidation ThT modes at atomic level. Here, we use ThT-detected 1H NMR identify strongly bound fibrils formed by islet polypeptide. Our results together with molecular rotor model proposed others provide characteristic amyloid-induced increase fluorescence. In species,...
Abstract Hepatocellular carcinoma (HCC) does not respond well to current treatments, even immune checkpoint inhibitors. PD‐L1 (programmed cell death ligand 1 or CD274 molecule)‐mediated escape of tumor cells may be a key factor affecting the efficacy inhibitor (ICI) therapy. However, regulatory mechanisms expression and require further exploration. Here, we observed that DDX1 (DEAD‐box helicase 1) was overexpressed in HCC tissues associated with poor prognosis patients HCC. Additionally,...
In sensorless control of permanent magnet synchronous motor (IPMSM) with sliding mode observer, the problem parameter robustness and poor stability seriously affects effect operation. Therefore, a fuzzy observer (SMO) phaselocked loop (PLL) combining particle swarm optimization (PSO) identification recursive least squares adaptive linear (RLS-Adaline) harmonic extractor is proposed. First, controller used to process parameters loop. Secondly, RLS-Adaline effectively filter higher component...
Cold environments, such as glaciers and alpine regions, constitute unique habitats for organisms living on Earth. In these harsh ecosystems, snow algae survive, florish, even become primary producers microbial communities. How the maintain physiological activity during violent ambient temperature changes remains unsolved. To explore cold adaptation mechanisms of unicellular alga Chlamydomonas nivalis , we compared its responses to a model organism from same genus, reinhardtii . When both...
Magnetic bearings have a series of excellent qualities, such as no friction and abrasions, high speed, accuracy, so on, which fundamentally innovated traditional forms support. In order to solve the problems large volume, low power density coupling coefficient three-pole magnetic bearings, six-pole AC active bearing is designed. Firstly, basic structure working principle two-degree-of-freedom (2-DOF) introduced. Secondly, suspension force modeling method 2-DOF based on Maxwell tensor...
The self-assembly of amyloid proteins into β-sheet rich assemblies is associated with human amyloidoses including Alzheimer's disease, Parkinson's and type 2 diabetes. An attractive therapeutic strategy therefore to develop small molecules that would inhibit protein self-assembly. Natural polyphenols are potential inhibitors formation. How these compounds affect the kinetics studied by thioflavin T (ThT) fluorescence not understood primarily because their presence interferes ThT...
In order to solve the problems of large volume and high cost a six-pole hybrid magnetic bearing (SHMB) with displacement sensors, estimation method using modified particle swarm optimization (MPSO) least-squares support vector machine (LS-SVM) is proposed. Firstly, inertial weight MPSO changed achieve faster iterations, prediction model an LS-SVM-based built. Secondly, simulated verified according parameters optimized by MPSO, predicted values PSO are compared. Finally, static dynamic...
Liver hepatocellular carcinoma (LIHC) is a highly malignant tumor with high metastasis and recurrence rates. Due to the relation between lipid metabolism immune microenvironment constantly being elucidated, this work carried out produce new prognostic gene signature that incorporates profiles of LIHC patients.We used "DEseq2" R package "Venn" identify differentially expressed genes related (LRDGs) in LIHC. Additionally, we performed unsupervised clustering patients based on LRDGs their...
Background. Circadian rhythm disruption involves tumorigenesis and tumor progression. However, the influences of circadian on microenvironment (TME) prognosis hepatocellular carcinoma (HCC) are unknown. Methods. Bulk RNA-seq single-cell from TCGA, ICGC, GEO were used to comprehensively identify prognostic control cells associated genes (CRRGs) using R Python packages. Besides, rhythm-related signature was identified validated. The biological function, immune infiltration, therapeutic...
In this study, we simulate double-gate MOSFET using a 2-D direct Boltzmann transport equation solver. Simulation results are interpreted by quasi-ballistic theory. It is found that the relation between average carrier velocity at virtual source and back-scattering coefficient needs to be modified due oversimplified approximations of original model. A 1-D potential profile model also extended better determine kT-layer length. The key expression for still valid, but field-dependent mean free...
The formation of amyloid fibrils is associated with incurable diseases including Alzheimer's, Parkinson's, and type 2 diabetes. Important mechanistic details the self-assembly are unknown partly because absence a clear structural characterization intermediates. There experimental evidence, however, for α-helical intermediates that has come primarily from circular dichroism spectroscopy. Here, we strengthen evidence helical by demonstrating helix-dipole effects in early events self-assembly....
The research object of this paper is the L-shaped plate–cavity coupling system established by a cuboid acoustic cavity with rigid-wall or impedance-wall and plate numerous elastic boundary conditions in view Fourier series method. main content vibro-acoustic characteristics. In paper, displacements admissible functions are generally set as sum two cosines’ product polynomials. Sound pressure can be considered three six discontinuity at all boundaries overall solution domain overcome way....
To reduce the coupling resulting from structural asymmetry and enhance load-bearing capacity per unit area, a six-pole axial-radial active magnetic bearing (AR-AMB) has been suggested.To refine precision of mathematical model derived conventional equivalent circuit model, modeling technique that employs flux density field segmentation proposed.Firstly, structure operational principle AR-AMB are introduced.Subsequently, an improved based on is established by considering internal relationship...
Outer rotor coreless bearingless permanent magnet synchronous generator is a complex and strongly coupled nonlinear system.The stable suspension voltage of are always the focus difficulty research.The fuzzy dynamic sequential model predictive torque control method based on prediction error compensation proposed.Firstly, basic structure working principle outer introduced in this paper, mathematical force established.Secondly, carried out to obtain equation, then number first output vectors...