A5101460522- Semiconductor materials and devices
- Astrophysics and Cosmic Phenomena
- GaN-based semiconductor devices and materials
- Gamma-ray bursts and supernovae
- RNA modifications and cancer
- Pulsars and Gravitational Waves Research
- Physiological and biochemical adaptations
- Bat Biology and Ecology Studies
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Ga2O3 and related materials
- Gestational Diabetes Research and Management
- Neurogenesis and neuroplasticity mechanisms
- Optical measurement and interference techniques
- Particle Detector Development and Performance
- Memory and Neural Mechanisms
- Dark Matter and Cosmic Phenomena
- Sirtuins and Resveratrol in Medicine
- Cancer-related gene regulation
- Pregnancy and preeclampsia studies
- Astrophysical Phenomena and Observations
- Ion-surface interactions and analysis
- Antioxidant Activity and Oxidative Stress
- Neurological Disease Mechanisms and Treatments
- Hormonal and reproductive studies
Center for Excellence in Brain Science and Intelligence Technology
2022-2025
Chinese Academy of Sciences
2019-2025
Wellcome Centre for Anti-Infectives Research
2024
ShanghaiTech University
2024
Gansu Great Wall Electrical and Electronics Engineering Research Institute
2024
Institute of High Energy Physics
2019-2024
University of Chinese Academy of Sciences
2022-2024
Purple Mountain Observatory
2024
Nanjing Medical University
2010-2024
China Electronic Product Reliability and Environmental Test Institute
2017-2021
Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 projectomes mouse HIP classified 43 projectome subtypes with distinct projection patterns. The number targets axon-tip distribution depended on soma location along longitudinal transverse axes. Many were enriched in specific subdomains defined by spatial transcriptomic profiles. Furthermore, delineated comprehensive wiring...
The fat mass and obesity-associated protein (FTO) was identified as a critical demethylase involved in regulating cellular mRNA stability by removing N6-methyladenosine (m6A) residues from mRNA. Emerging evidence has revealed that FTO is deeply implicated lung cancer. However, knowledge of the function adenocarcinoma (LUAC) limited.FTO R96Q (R96Q), an missense mutant lacking activity, were ectopically overexpressed, knocked down via siRNA A549 H1299 cells. relationships between with cell...
Prostate cancer (PCa) is one of the most common epithelial malignant tumors and fifth leading cause death in men.An increasing number studies have demonstrated that N6-methyladenosine (m 6 A) plays a crucial role tumorigenesis tumor development.However, little known about levels m A regulators PCa.In this study, we analyzed characteristic expression PCa castration-resistant prostate (CRPC).UALCAN cBioPortal were used to estimate clinical value genetic alterations regulators, respectively.The...
The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying northern γ-ray sky energies above 10 TeV with unprecedented sensitivity. observations have long been one most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by decays heavy particles. In this Letter, we present first analysis LHAASO-KM2A, using 340 days data from 1/2-KM2A and 230 3/4-KM2A. Several regions interest are used to search a signal...
Abstract The aim of the present study was to determine effect dietary lysozyme levels on growth performance, gut health and non‐specific immunity weanling piglets. A total 150 piglets were allocated six treatments. fed same basel diet supplemented with 0, 30, 60, 90 120 mg/kg as well antibiotics for 28 days. From day 14 treatment, had greater average daily gain than control diet. During whole experimental period, tended have Compared diet, diets containing villus height crypt depth ratio in...
ABSTRACT We conduct a comprehensive analysis of the accreting X-ray pulsar, Hercules X-1, utilizing data from Imaging Polarimetry Explorer (IXPE) and Nuclear Spectroscopic Telescope Array. IXPE performed five observations Her consisting three in Main-on state two Short-on state. Our time-resolved uncovers linear correlations between flux polarization degree as well pulse fraction degree. Geometry parameters are rigorously constrained by fitting phase-resolved modulations Cyclotron Resonance...
We consider how to cover the most area inside of a circular disc by using finitely many triangles. Even in simple cases with number triangles being small, we do not know what is maximum that can be covered. However, as tends infinity, use some estimates and existing literature derive rate uncovered goes zero.
N-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds selectively targeting with antidepressant effects been identified. Here, we present YY-23, a compound that inhibits GluN2C- or GluN2D-containing NMDARs. Cryo-EM analysis revealed YY-23 binds to the transmembrane domain GluN2D subunit. primarily affects on...
RNA N 6 -methyladenosine (m A) demethylase AlkB homolog 5 (ALKBH5) plays a crucial role in regulating innate immunity. Lysine acylation, widespread protein modification, influences function, but its impact on ALKBH5 during viral infections has not been well characterized. This study investigates the presence and regulatory mechanisms of previously unidentified lysine acylation mediating m A modifications to activate antiviral immune responses. We demonstrate that undergoes lactylation, which...
Despite the fact that skeletal muscle insulin resistance is hallmark of type-2 diabetes mellitus (T2DM), inflexibility in substrate energy metabolism has been observed other tissues such as liver, adipose tissue, and heart. In heart, structural functional changes ultimately lead to diabetic cardiomyopathy. However, little known about early biochemical cause cardiac metabolic dysregulation dysfunction. We used a dietary model fructose-induced T2DM (10% fructose drinking water for 6 weeks)...
The related recovery effect of hydrogen on AlGaN/gallium nitride (GaN) high-electron-mobility transistors (HEMTs) irradiated by high-fluence protons was investigated in this article. results show that under the same temperature and time conditions, induced thermal annealing is better than ordinary annealing. Compared with annealing, proton-irradiated device experienced a 65-mA additional increase saturation current at gate-to-source voltage (V <sub...
Abstract Non-small cell lung cancer (NSCLC) is the major cause of mortality worldwide. Though multidisciplinary therapies have been widely used for NSCLC, its overall prognosis remains very poor, presumably owing to lack effective prognostic biomarkers. SMAD , a well-known transcription factor, plays an essential role in carcinogenesis. Aberrant expression found various cancers, and may be regarded as indicator some malignancies. However, family member, especially at mRNA level, remain...
Hormone replacement therapy (HRT) has been used to prevent osteoporosis in postmenopausal women. However, HRT is not for everyone, due concerns of side effects as well increased risk breast and possibly uterine cancer. Therefore, Dietary alternatives are considered, which include Trans-3,5,4'-Trihydroxystilbene (trans-resveratrol), a phytoestrogen naturally found grapes, peanuts wine with beneficial both cardioprotective chemopreventive. The purpose this study was evaluate the...
Heavy ion-induced electrical degradations and mechanisms of high-electron-mobility transistors (HEMTs) were investigated in this article. AlGaN/GaN HEMTs irradiated by 800-MeV Bi ions with total fluence 5.23×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> ions/cm xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The results show that the saturation current decreased 13.1%, threshold voltage negatively shifted 0.21 V, peak...
A deep level transient spectroscopy (DLTS) study has been performed on a GaN n+-p junction fabricated by implanting Si into Mg-doped p-type epilayer. high concentration of defect revealed within the interfacial region junctions unusual appearance minority peak in majority carrier DLTS spectra. The appears to be an electron trap at EC-0.59 eV p-side and tentatively attributed VN–Mg complex. this electrically active depletion layer Si-implanted diodes suggests need for further investigations.
The nearby radio galaxy M87 is a very-high-energy (VHE) gamma-ray emitter established by observations with ground-based detectors. Here we report the long-term monitoring of from 2021 to 2024 Large High Altitude Air Shower Observatory (LHAASO). has been detected LHAASO statistical significance $\sim 9\sigma$. observed energy spectrum extends 20 TeV, possible hardening at 20$ TeV and then clear softening higher energies. Assuming that intrinsic described single power law up tight upper bound...