A5102925653- Asthma and respiratory diseases
- Pleural and Pulmonary Diseases
- Respiratory and Cough-Related Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Immunodeficiency and Autoimmune Disorders
- Occupational and environmental lung diseases
- Lung Cancer Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Inflammation biomarkers and pathways
- Ultrasound in Clinical Applications
- Myasthenia Gravis and Thymoma
- Neuroendocrine Tumor Research Advances
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Pericarditis and Cardiac Tamponade
- Circular RNAs in diseases
- Inhalation and Respiratory Drug Delivery
- Antibiotic Resistance in Bacteria
First Affiliated Hospital of GuangXi Medical University
2010-2025
Guangxi Medical University
2011-2025
Wenzhou Medical University
2024-2025
First Affiliated Hospital of Wenzhou Medical University
2024-2025
State Key Laboratory of Respiratory Disease
2021
Chinese General Hospital College of Nursing and Liberal Arts
1995
Abstract IL-17–producing CD4+ T (Th17) cells have been found to be increased in some human cancers; however, the possible implication of Th17 regulating antitumor responses malignant pleural effusion (MPE) remains elucidated. In current study, distribution and phenotypic features both MPE peripheral blood from patients with lung cancer were determined by flow cytometry or double immunofluorescence staining. The impacts cytokines on cell generation differentiation explored. chemoattractant...
In order to investigate the role of interleukin-5 (IL-5) in airway hyperreactivity and eosinophilia, we observed effect inhaled recombinant human IL-5 on responsiveness methacholine cell populations induced sputum eight patients with allergic bronchial asthma using a placebo-controlled study design. Our results demonstrated that inhalation did not alter lung function asthmatics. control experiments receiving either vehicle or 0.4 ng endotoxin, PC20 values change nor numbers eosinophils...
Newly discovered IL-9-producing CD4(+) helper T cells (Th9 cells) have been reported to contribute tissue inflammation and immune responses, however, differentiation regulation of Th9 in tuberculosis remain unknown. In the present study, our data showed that increased with phenotype effector memory were found be tuberculous pleural effusion as compared blood. TGF-β was essential for cell from naïve stimulated PMA ionomycin vitro 5 h, addition IL-1β, IL-4 or IL-6 further augmented...
The fat mass and obesity-associated protein (FTO) was identified as a critical demethylase involved in regulating cellular mRNA stability by removing N6-methyladenosine (m6A) residues from mRNA. Emerging evidence has revealed that FTO is deeply implicated lung cancer. However, knowledge of the function adenocarcinoma (LUAC) limited.FTO R96Q (R96Q), an missense mutant lacking activity, were ectopically overexpressed, knocked down via siRNA A549 H1299 cells. relationships between with cell...
Omadacycline is a novel aminomethylcycline antibiotic that retains its antibacterial activity against strain-specific efflux pumps and ribosomal protective protein mechanisms of tetracycline resistance. To determine the concentration omadacycline in human plasma, an ultra-high-performance liquid chromatography-tandem mass spectrometry method was developed to provide basis for therapeutic monitoring clinical settings. The experimental approach involves using ACQUITY UPLC BEH C18 column (2.1 ×...
lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order investigate IL-4 airway hyperreactivity, we investigated effect inhaled recombinant human on responsiveness methacholine and eosinophil numbers induced sputum eight patients with asthma using placebo-controlled study design. Our results demonstrated that control experiments receiving vehicle inhalation, PC20 values did not change nor eosinophils from...
Interleukin (IL)-5 is thought to play an important role in asthmatic bronchial mucosal inflammation and a potential therapeutic target. To investigate the effect of IL-5 on infiltration eosinophils airway vivo, we compared eosinophil counts their activation status airways without after topical instillation recombinant human IL-5. Eight subjects with mild atopic asthma underwent initial bronchoscopy during which control bronchoalveolar lavage (BAL) fluid as well mucosa were obtained, at same...
Abstract Background Both regulatory T cells (Tregs) and helper IL-17-producing (Th17 cells) have been found to be involved in human malignancies, however, the possible implication of Tregs regulating generation differentiation Th17 malignant pleural effusion remains elucidated. Methods The numbers both CD39 + peripheral blood from patients with lung cancer were determined by flow cytometry. regulation mechanism on explored. Results increased when compared blood, correlated negatively those...
To discuss and assess the clinical value of treating lung cancer cachexia with thalidomide combined cinobufagin.s.A cohort 54 patients, who were diagnosed carcinoma, was randomly divided into two groups, a trial group control group, respectively. The given 150 mg/day 2700 cinobufagin; only received 2,700 cinobufagin. therapy lasted for 12 weeks, nutritional status, quality life, survival, side effects in patients groups recorded.The survival significantly improved compared to group. mg...
ABSTRACT Background and Objective: CD4 + CD25 high regulatory T cells are increased in tuberculous pleural effusions (TPE). However, the mechanism by which infiltrate into cavity is unknown. The aim of this study was to investigate whether chemokines CCL22 CCL17 present TPE, chemoattractant activity these for infiltration space. Methods: concentrations were measured from 33 patients with pleurisy, 21 bacterial infections 18 transudative effusions. lymphocyte subsets assessed flow cytometry....
Lung cancer is a high incidence on worldwide basis and has become major public health problem. adenocarcinoma (LUAD) makes up approximately half of all lung cancers threat to human health. Long non-coding RNAs (lncRNAs) an important regulator the development progression adenocarcinoma. In this manuscript we examined role potential mechanism lncRNA PCAT6 in LUAD.Differences levels between LUAD samples normal were first explored GEPIA database. We found that expression was elevated, which also...
Anti-interferon-γ autoantibodies (AIGAs) syndrome is susceptible to disseminated opportunistic infections due increased AIGAs, but its clinical immunological characteristics remain unrecognized. We conducted a prospective cohort study between January 2021 and December 2023, recruiting patients with who were categorized into AIGAs-positive AIGAs-negative groups. Clinical data outcomes documented. A subset of received glucocorticoid treatment, effectiveness was evaluated. total 238 enrolled,...
Long non-coding RNAs (lncRNAs) play a crucial role in tumor generation and progression. However, the exact functional significance underlying molecular mechanism by which lncRNA CERS6-AS1 operates context of lung adenocarcinoma (LUAD) remain unknown. We aimed to evaluate potential CERS6-AS1/miR-424-5p/ANLN axis progression LUAD through bioinformatics cytobehavioral experiments, provide new insight into combined treatment LUAD. Based on TCGA database, expression pan-cancer was evaluated, its...
Background: Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 (NEDD1) serves as a crucial factor in promoting cellular mitosis by directly facilitating wheel assembly and daughter centriole biogenesis at the lateral site of parent centrioles, ultimately driving centrosome replication.The amplification centrosomes abnormal expression centrosome-associated proteins contribute to invasion metastasis non-small cell lung cancer cells.However, specific mechanism which NEDD1...