A5114461951- Pleural and Pulmonary Diseases
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Dermatological and COVID-19 studies
- RNA modifications and cancer
- Myasthenia Gravis and Thymoma
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- Aluminum Alloys Composites Properties
- Magnesium Alloys: Properties and Applications
- Metastasis and carcinoma case studies
- Differential Equations and Numerical Methods
- Long-Term Effects of COVID-19
- Fractional Differential Equations Solutions
- T-cell and B-cell Immunology
- Gastrointestinal Tumor Research and Treatment
- Solidification and crystal growth phenomena
- Colorectal Cancer Surgical Treatments
- Biochemical and Molecular Research
- Occupational and environmental lung diseases
Children's Hospital of Fudan University
2025
Soochow University
2020-2024
Central South University
2008-2024
Theranostics (New Zealand)
2021-2024
Guangxi Medical University
2009-2024
Zhongshan Hospital of Xiamen University
2010-2024
Xiamen University
2020-2024
First People's Hospital of Foshan
2014-2023
Soochow University
2020-2022
The Fifth People’s Hospital of Suzhou
2018-2022
Abstract IL-17–producing CD4+ T (Th17) cells have been found to be increased in some human cancers; however, the possible implication of Th17 regulating antitumor responses malignant pleural effusion (MPE) remains elucidated. In current study, distribution and phenotypic features both MPE peripheral blood from patients with lung cancer were determined by flow cytometry or double immunofluorescence staining. The impacts cytokines on cell generation differentiation explored. chemoattractant...
Rationale: IL-9–producing CD4+ T cells (Th9 cells) have been reported to be involved in inflammation and immune diseases. However, the involvement of Th9 malignancy has not investigated.Objectives: To elucidate mechanism by which differentiate malignant pleural effusion (MPE) explore regulation on lung cancer cells.Methods: Distribution relation Th17 Th1 both MPE blood were determined. The effects mechanisms proinflammatory cytokines regulatory differentiation vitro explored. impacts signal...
Newly discovered IL-9-producing CD4(+) helper T cells (Th9 cells) have been reported to contribute tissue inflammation and immune responses, however, differentiation regulation of Th9 in tuberculosis remain unknown. In the present study, our data showed that increased with phenotype effector memory were found be tuberculous pleural effusion as compared blood. TGF-β was essential for cell from naïve stimulated PMA ionomycin vitro 5 h, addition IL-1β, IL-4 or IL-6 further augmented...
Abstract Purpose: The aim of this study was to explore the presence chemokines CCL22 and CCL17 in malignant pleural effusion, chemoattractant activity these on CD4-positive CD25-positive Foxp3-positive regulatory T cells infiltrating into space. Experimental Design: concentrations both effusions sera from 33 patients with lung cancer were determined. Flow cytometry done determine lymphocyte subsets cell pellets effusion. Pleural analyzed for expression CCL17. vitro vivo also observed....
Abstract Background Patients with IL10RA-deficient inflammatory bowel disease (IBD) generally have a poor prognosis, high mortality and significant rate of intestinal surgeries. Hematopoietic stem cell transplantation (HSCT) is currently the main cure, but most patients still face death after transplantation. The study analyzes prognosis without HSCT, aiming to explore factors associated both need for surgery, as well establish short-term prognostic models. Methods retrospectively enrolled...
Abstract Background Both regulatory T cells (Tregs) and helper IL-17-producing (Th17 cells) have been found to be involved in human malignancies, however, the possible implication of Tregs regulating generation differentiation Th17 malignant pleural effusion remains elucidated. Methods The numbers both CD39 + peripheral blood from patients with lung cancer were determined by flow cytometry. regulation mechanism on explored. Results increased when compared blood, correlated negatively those...
The objective of the present study was to investigate presence interleukin (IL)-27 in pleural effusions and evaluate diagnostic significance IL-27. concentrations IL-27 were determined fluids sera from 68 patients with tuberculous effusion, 63 malignant 22 infectious 21 transudative effusion. Flow cytometry used identify which cell types expressed It found that group significantly higher than those malignant, infectious, groups, respectively. Pleural CD4+ T cells, CD8+ NK NKT B monocytes,...
Rationale: IL-22–producing helper T cells (Th22 cells) have been reported to be involved in tuberculosis infection. However, differentiation and immune regulation of Th22 tuberculous pleural effusion (TPE) remain unknown.Objectives: To elucidate the mechanism by which differentiate recruit into space.Methods: The distribution phenotypic features both TPE blood were determined. impacts proinflammatory cytokines antigen presentation mesothelial (PMCs) on Th22-cell explored. chemoattractant...
Background Previous studies reported interleukin-27 (IL-27), interferon-γ (IFN-γ), or adenosine deaminase (ADA) alone plays a helpful role in diagnosing tuberculous pleural effusion (TPE). The present study aims at comparing the diagnostic accuracy of IL-27, IFN-γ, and ADA, investigate combination or/ ADA for differentiating TPE from effusions with other etiologies. Methods concentrations IFN-γ were simultaneously determined fluids sera 40 patients TPE; 26 malignant effusion, seven...
Jasmonate is an important endogenous chemical signal that plays a role in modulation of plant defense responses. To understand its mechanisms regulation rice resistance against the fungal pathogen Magnaporthe oryzae, comparative phenotype and proteomic analyses were undertaken using two near-isogenic cultivars with different levels disease resistance. Methyl-jasmonate (MeJA) treatment significantly enhanced M. oryzae both but treated resistant cultivar maintained higher level than same...
Cancer cells metabolize different energy sources to generate biomass rapidly. The purine biosynthetic pathway was recently identified as an important source of metabolic intermediates for these processes. However, very little known about the regulatory mechanisms metabolism in hepatocellular carcinoma (HCC). We explored role dual‐specificity tyrosine (Y) phosphorylation–regulated kinase 3 (Dyrk3) HCC metabolism. Dyrk3 significantly down‐regulated compared with normal controls. Its...
ABSTRACT Both T helper interleukin 17 (IL-17)-producing cells (Th17 cells) and regulatory (Tregs) have been found to be increased in human tuberculous pleural effusion (TPE); however, the possible interaction between Th17 Tregs TPE remains elucidated. The objective of present study was investigate distribution relation Tregs, as well mechanism regulating generation differentiation TPE. In study, numbers blood were determined by flow cytometry. regulation CD39 + on explored. Our data...
The difference between left- and right-sided colon cancer has become the focus of global attention, researchers have found differences in morbidity, molecular biological characteristics, response to targeted drug therapy cancer. Therefore, identification more effective predictive indicators is critical for providing guidance future clinical work. We collected samples from different sites regions analyzed identities distributions differentially expressed species microbiota left right sides...
Laparoscopic radical gastrectomy is widely used, and perioperative complications have become a highly concerned issue.
The chimeric Pt(<sc>iv</sc>)–Ru(<sc>ii</sc>) complex was designed to simultaneously release cytotoxic cisplatin and an antimetastatic Ru(<sc>ii</sc>)–arene compound, thereby producing potent anticancer activity with high drug tolerability in animals.
Purpose We aimed to evaluate whether the addition of pemetrexed is effective in improving progression-free survival (PFS) epidermal growth factor receptor (<i>EGFR</i>)–mutated patients with or without concomitant alterations.Materials and Methods This multicenter clinical trial was conducted China from June 15, 2018, May 31, 2019. A total 92 non–small cell lung cancer (NSCLC) harboring EGFR-sensitive mutations were included divided into non-concomitant groups. Patients each...