A5101461042- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and treatment of tuberculosis
- Cancer Immunotherapy and Biomarkers
- Infectious Diseases and Tuberculosis
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Dermatological and COVID-19 studies
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Vitamin D Research Studies
- Elbow and Forearm Trauma Treatment
- Tendon Structure and Treatment
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Acute Myocardial Infarction Research
- Silymarin and Mushroom Poisoning
- Childhood Cancer Survivors' Quality of Life
- Hematological disorders and diagnostics
The Fifth People’s Hospital of Suzhou
2015-2025
Soochow University
2015-2024
Fujian Medical University
2024
Soochow University
2023-2024
The Fourth People's Hospital
2015
There was much evidence suggesting that the serum lactate dehydrogenase (LDH) levels reflect extent of various pathophysiological processes. However, current information about dynamic change LDH in COVID-19 pneumonia has not been well investigated. Study performed 87 cases confirmed by infection. The were determined at diagnosis and follow-up visits. evaluation clinical response to therapy based on chest CT scan. We selected value around data scan (− 1 ~ + day). At diagnosis, significant...
Tuberculosis (TB) remains a serious global public health problem in the present. TB also affects other sites (extrapulmonary tuberculosis, EPTB), and accounts for significant proportion of tuberculosis cases worldwide. In order to comprehensively understand epidemiology EBTB China, improve early diagnosis treatment, we conducted large-scale multi-center observational study assess demographic data prevalence common EPTB inpatients, further evaluate concurrent with Pulmonary (PTB) associations...
AimsA high proportion of all patients with tuberculosis (TB) present extrapulmonary TB (EPTB), including concurrent EPTB involving more than one lesion site. However, previous reports only characterized lesions single-site cases. This study aimed to investigate epidemiological characteristics and association rules cases in China.MethodsAn observational multi-centre 208,214 was undertaken China from January 2011 December 2017. Multi-variable logistic regression analysis used identify...
Background: The aim of this study was to identify the differences in diversity, composition, and function gut microbiota between tuberculosis (TB) patients healthy controls (HCs).Methods: A cross-sectional conducted three cities China. Stool samples from 94 treatment-naive TB 62 HCs were analyzed by 16S rRNA gene sequencing. further divided into antibiotic-free antibiotic-exposure according their use non-specific antibiotics before diagnosis.Results: Compared with HCs, presented a different...
Fosfomycin, with its unique mechanism of action, has emerged as a promising option for clinicians to combat antimicrobial resistance and the limited availability effective drugs, which led an increase in associated adverse events (AEs). This study aims explore AEs caused by fosfomycin through data mining US FDA Adverse Event Reporting System (FAERS) inform clinical safety. As revealed FAERS, 796 fosfomycin-associated occurred more commonly females (61.90%), Italy reporting highest incidence...
T-cell-based gamma interferon (IFN-γ) release assays (IGRAs) using Mycobacterium tuberculosis-specific antigens have shown higher sensitivity and specificity than the routine tuberculin skin test (TST). However, effects of bovis BCG vaccination anti-tuberculosis (TB) treatment on dynamic T-cell responses to M. in active TB cases rarely been investigated regions where is endemic. Eighty-nine patients with pulmonary (ATB) 57 healthy controls (HC) from China were recruited tested by sputum...
Objectives: Subclinical tuberculosis (TB) represents a substantial proportion of individuals with TB disease, although limited evidence is available to understand the epidemiological characteristics these cases. We aimed explore prevalence subclinical patients and identify underlying association between cases in study setting Beijing genotype. Methods: A retrospective was conducted among incident at Fifth People's Hospital Suzhou January December 2018. total 380 were included our analysis....
Abstract Background sCD25 is an important immune molecule for T cell regulation. Tracking the detection of plasma plays role in evaluation function, progression, and prognosis tuberculosis (TB) patients. This study analyzed association levels with clinical, laboratory, CT imaging characteristics, clinical outcome TB Methods The data 303 patients treated Fifth People’s Hospital Suzhou from October 2019 to January 2022 were retrospectively analyzed. detected by ELISA. According cut-off...
The current treatment for multidrug-resistant tuberculosis (MDR-TB) takes a lengthy period of 18-24 months and has poor cure rate 50-60%. A multicenter, prospective cohort study was conducted to assess the role testing molecular susceptibility pyrazinamide (PZA) in optimising MDR-TB.We assigned 76 patients an optimised group 159 regular where PZA not determined. Of these patients, 152 were matched after propensity score matching (76 group). Treatment success measured propensity-matched as...
Tuberculosis (TB), a multisystemic disease with protean presentation, remains major global health problem. Although concurrent pulmonary tuberculosis (PTB) and extrapulmonary (EPTB) cases are commonly observed clinically, knowledge regarding PTB-EPTB is limited. Here, large-scale multicenter observational study conducted in China aimed to the epidemiology of by diagnostically defining TB types then implementing association rules analysis.The retrospective was at 21 hospitals 15 provinces...
Programmed death-1 (PD-1) expression has been revealed to be upregulated on T cells and contributes cell exhaustion in patients with hepatitis B virus (HBV) infection. In this study, we investigated the dynamic of programmed death ligand-1 (PD-L1), ligand PD-1, circulating CD14+ monocytes CD19+ HBV-infected at stages chronic HBV (CHB) infection, liver cirrhosis (LC), hepatocellular carcinoma (HCC), respectively. The results showed that compared healthy controls, levels PD-L1 populations were...
Exploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing management multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate association between exposure, susceptibility, MDR-TB treatment, as well find clinical thresholds pyrazinamide. A prospective multi-center cohort participants with using was conducted in three TB-designated hospitals China. Univariate multivariate analyses were applied associations....
To investigate the prevalence of and risk factors for leukopenia in tuberculosis patients impact anti-tuberculosis regimens on occurrence newly treated patients.A total 1,904 were included study. A cross-sectional survey was initially conducted, then influencing identified using Logistic regression analysis. Non-treatment peripheral blood leukocyte counts analyzed univariate COX proportional hazards models. Covariate analysis used to assess independent effect different counts.Being female,...
Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate value IGRA diagnosis active pulmonary (PTB) China.We conducted a large-scale retrospective multicenter investigation further evaluate role PTB TB-epidemic populations factors affecting performance assay. All patients who underwent valid T-SPOT.TB assays December 2012...
xCT forms part of the xc- cysteine-glutamate antiporter which inhibits antimicrobial inflammatory immune functions and thus increases susceptibility to tuberculosis (TB). However, associations between gene polymorphisms TB, as well whether these modulate expression or affect treatment with inhibitor sulfasalazine (SASP), are unclear. In present study, we genotyped in a large Chinese cohort found that single-nucleotide polymorphism (SNP) rs13120371 was associated TB. The AA genotype strongly...
Objective Tuberculosis ( TB )‐interferon gamma release assay IGRA ) test has the characteristics of short time, high specificity, and sensitivity, but it lacks correlation research between ‐ results body's immune cells, disease progression prognosis, which is explored in this study. Design A retrospective study was carried out on positive patients who were infected with diagnosed at our hospital from January 2014 to June 2015. The , routine blood test, T‐cell subgroup data collected for...
As an immune checkpoint, upregulation of B and T lymphocyte attenuator (BTLA) contributes to T-cell exhaustion in chronic infection. However, the characteristics BTLA on cells patients with pulmonary tuberculosis (PTB) are still uncovered.The aim study was elucidate dynamics clinical significance expression circulating CD4+ CD8+ PTB patients.BTLA from smear positivity (n = 86) healthy controls (HCs) 40) were determined using flow cytometry.The levels both upregulated, compared HC. At same...
The objective of the present study was to evaluate potential development DNA microarray chips detect rifampicin (RFP) and isoniazid (INH) resistance in Mycobacterium tuberculosis (MTB), using samples from clinical (TB) patients Soochow City, China. sputum 42 with TB Affiliated Hospital Infectious Diseases University (Soochow, China) were collected. conventional Lowenstein-Jensen culture medium (Gold Standard) used assess drug sensitivity absolute concentration method. GeeDom MTB detection...