A5042416654- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Infectious Diseases and Tuberculosis
- Cancer Cells and Metastasis
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Tissue Engineering and Regenerative Medicine
- Metastasis and carcinoma case studies
- Hematological disorders and diagnostics
- Lung Cancer Research Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Congenital Heart Disease Studies
- Hydrogen's biological and therapeutic effects
- Ideological and Political Education
- Bacterial Infections and Vaccines
- Immunodeficiency and Autoimmune Disorders
- Erythropoietin and Anemia Treatment
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
Hospital of Hebei Province
2010-2024
Hebei Medical University
2023-2024
Sun Yat-sen University
2024
Weatherford College
2021
Background: Asymptomatic patients are unneglected sources in propagating transmission chain due to their high viral loads. However, treatments available based on symptoms seem not applicable asymptomatic patients. In this study, the authors want estimate effectiveness of Lianhua Qingwen (LH) capsule coronavirus disease 2019 (COVID-19) Methods: A randomized controlled trial (RCT) was performed explore and safety LH treating COVID-19 Patients were control group (isolated observation) treatment...
Lianhua Qingke (LH) tablets is an effective traditional Chinese medicine against various viral infections, especially in relieving coughing. However, its effects on COVID-19 are unknown.To examine the therapeutic effectiveness of LH patients with mild and common types, a randomized, multicenter, controlled study was carried out. cases were randomized to undergo routine treatment or without (4 tablets, three times day) for 14 days. The primary endpoints rate achieving clinical symptom...
Circulating tumor cells are complete with multi-scale analysis values that present a high potential for lung cancer diagnosis. To enhance the accuracy of diagnosis, we detected circulating by innovated conical micro filter integrated microfluidic system.We recruited 45 subjects study, including 22 patients, 2 precancerous control group 14 healthy participants, and 7 patients benign lesions in this prospective study. We calculated area under receiver operating characteristic curve cells,...
Interferon-gamma release assay (IGRA) has been used in latent tuberculosis (TB) infection and TB diagnosis, but the results from different high TB-endemic countries are different. The aim of this study was to investigate value IGRA diagnosis active pulmonary (PTB) China.We conducted a large-scale retrospective multicenter investigation further evaluate role PTB TB-epidemic populations factors affecting performance assay. All patients who underwent valid T-SPOT.TB assays December 2012...
Fascin is an actin-binding protein that promotes tumor metastasis. The inhibition of fascin on the progress non-small cell lung cancer (NSCLC) not very clear. Hence, this study explored potential effect NP-G2-044, a novel inhibitor, in human NSCLC lines and Lewis (LCC) mice model.
Bacterial culture of M. tuberculosis (MTB), the causative agent (TB), from clinical specimens is gold standard for laboratory diagnosis TB, but slow and culture-negative TB cases are common. Alternative immune-based molecular approaches have been developed, cannot discriminate between active (ATB) latent (LTBI). Here, to identify biomarkers that can ATB LTBI/healthy individuals (HC), we profiled 116 serum samples (HC, LTBI ATB) using a protein microarray containing 257 MTB secreted proteins,...
We compared the positive rates of T-SPOT.TB and bacterial culture in smear-negative PTB, analyzed factors affecting results negative culture. Retrospective evaluation data from PTB patients who underwent were done. The agreement concordance between Multivariable logistic regression analysis was used to explore associated with PTB. 858 eligible included study. rate 25.6% (22.7~28.5%) smear- patients. higher than that (p < 0.001). There nearly no > 0.05). Using multivariable we found older age...
The lack of efficacious vaccines against Mycobacterium tuberculosis (MTB) infection is a limiting factor in the prevention and control (TB), leading cause death from an infectious agent. Improvement or replacement BCG vaccine with one that reliably protects all age groups urgent. Concerns exist antigens currently being evaluated are too homogeneous. To identify new protective antigens, we screened 1,781 proteins high-throughput proteome-wide protein purification study for antigenic activity....
9136 Background: Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), is used extensively in the treatment of malignancies when combined with chemotherapy. While chemotherapeutic agents are known to cause dose-limiting bone marrow suppression including anemia, role VEGF and its inhibition by bevacizumab this process not known. Therefore, we conducted meta- analysis randomized controlled trials (RCT) determine effect on severe anemia induced Methods:...
High sensitive immune CD133 PLGA magnetic spheres platform is constructed to isolate and enrich lung cancer stem cells in order study their biological characteristics, such as proliferation, self-renewal invasion metastasis vitro. The expression of the specific transcription factors Oct 4 Nanog genes were detected by immunofluorescence RT-PCR. tumorigenic capacity studied using tumorigenesis experiment nude mice vivo. results indicated that beads (with diameter 356.25 ± 0.64 nm) can...
Background: Lung cancer is the leading cause of death in most countries. Although early diagnosis and treatment critically influence prognosis, lung cancers are generally only discovered late stages disease. Objective: Widely-used screening diagnostic methods not suitable for preventive screening, high-throughput technologies based on serum biomarkers needed. Methods: We screened 501 samples, including 224 (LC), 126 disease control (DC), 151 healthy donor (HC) samples new autoantibodies as...
Abstract Background Dynamic assessment of cerebrospinal fluid (CSF) is essential for diagnosis, treatment, and prognosis tuberculous meningitis, one the most severe forms central nervous system (CNS) infection. Case presentation A 45‐year‐old man sought care as he developed confusion, clonic convulsion, coma. Longitudinal, comprehensive analyses cytological, biochemical, microbial changes in CSF specimen were assessed this patient. On day 1 hospitalization, modified Ziehl‐Neelsen staining...
Abstract The T-SPOT. TB assay detects cellular immune responses to 2 core Mycobacterium tuberculosis antigens, early secreted antigenic target of 6-kDa protein (ESAT-6) and culture filtrate protein-10 (CFP-10). has been recently used for auxiliary diagnosis active pulmonary (PTB). However, testing can produce inconsistent results due differential PTB patient these prompting us identify factors underlying results. Data were retrospectively analyzed from 1225 confirmed patients who underwent...
Introduction: Inflammation and oxidative stress are important factors in the pathogenesis of Chronic obstructive pulmonary disease (COPD). Current treatments for COPD focus on improving symptoms caused by inflammation rather than curing disease, therefore, emerging research focusing upstream pathways may help develop effective treatments. Epidemiological investigations have shown that exposure to fine particulate matter (PM2.5) can cause lung through nuclear factor NF-E2-associated (Nrf2)...
Abstract It is crucial to maintain continuity of essential services for people affected by tuberculosis (TB). Efforts deliver these in many global settings have been complicated the emergence and spread SARS-CoV-2 pandemic COVID-19. Understanding how COVID-19 has impacted availability TB diagnostic treatment critical identifying policies that can mitigate disruptions services. China a dual burden We conducted survey collected data from 13 provinces evaluate early impact on document...
Smoking is considered a serious risk factor for developing large array of cardiopulmonary conditions, in particular, squamous cell carcinoma non-small lung cancer (NSCLC). cessation has reduced the cancers and benefited patients receiving chemotherapy. While selective chemotherapeutic agents have been developed, analysis drug efficacy smoking populations not extensively studied. Recently, some clinical trials shown that smokers with NSCLC lower hazard ratio (HR) than non-smokers, or heavy HR...
Tuberculosis (TB) has raised major global health concerns, especially for that caused by drug-resistant Mycobacterium tuberculosis (M. tuberculosis). The control of TB was hampered time-consuming and insensitive diagnostic methods. GeneChip analysis is a rapid method screening identifying the gene mutations M. tuberculosis. However, there little relevant information about in China.To compare performance diagnosis with traditional drug susceptibility testing (DST), 1,747 sputum specimens from...
Objective: To evaluate the clinical value of a pulmonary tuberculosis CT diagnostic model based on deep learning convolutional neural networks (CNN). Methods: From March 2017 to 2018,a total 1 764 patients with positive sputum for tuberculous bacterium and had received high-resolution chest scan in radiology department Hebei province hospital were enrolled. Among them, 937 male, 827 female, aging from 17-73 years (average 38.4). A 20 139 images (17 kinds image features) classified by 4...