A5101905652- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- X-ray Diffraction in Crystallography
- Diagnosis and treatment of tuberculosis
- Crystallization and Solubility Studies
- Immune cells in cancer
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Lung Cancer Research Studies
- Superconducting Materials and Applications
- Inflammasome and immune disorders
- Anesthesia and Sedative Agents
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Protein Degradation and Inhibitors
- Cardiac Ischemia and Reperfusion
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Immune Response and Inflammation
Hospital of Hebei Province
2014-2022
miR-410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role NSCLC is still unknown. In this study, we showed that the expression of was up-regulated both human tissues and cells. Overexpression promoted cell proliferation, migration, invasion NSCLC. addition, bromodomain-containing protein 7 (BRD7) a direct target miR-410. MiR-410-mediated downregulation BRD7 led to increase Akt phosphorylation. Inhibition phosphorylation can rescue effect on cell. The...
Background.Epidemiological studies and mice models have demonstrated that air pollution containing particulate matter smaller than 2.5 µm (PM2.5)exacerbates acute episodes of asthma in both children adults. Objectives.To investigate the effect continuous PM2.5 treatment on regulation mechanism behind this effect. Material methods.In study, effects exposure to eosinophil recruitment was compared a single pre-ovalbumin (OVA)-sensitization PM2.5.Wild-type were either challenged once with + OVA...
// Dengrui Li 1, * , Guiyun Zhu 2, Hongqin Di 3 Hui 4 Xinyan Liu 5 Min Zhao 6 Zhihua Zhang 7 Yonghui Yang 2 1 Department of General Internal Medicine, Chest Hospital Hebei Province, Lung Cancer Prevention and Control Center Shijiazhuang, Hebei, China, 050041 Pathology, Clinical Laboratory, Thoracic Surgery, The First Oncology, Second Medical Department, These authors contributed equally to this work Correspondence to: Yang, email: yangyonghuihb@126.com Keywords: microRNAs, lung cancer,...
Wild-type p53-induced phosphatase 1 (Wip1), also termed PPM1D, is a member of the protein 2C family, which characterized by distinctive oncogenic properties. Overexpression Wip1 observed in certain types human tumors that are associated with significantly poor prognosis. The present study aimed to detect expression non‑small cell lung cancer (NSCLC) and analyze its prognostic value such patients. level was compared between NSCLC normal tissue specimens using immunohistochemistry, it found...
Tumor mutation burden (TMB) is an independent indicator used to select patients sensitive immunotherapy. The present study aimed investigate the clinicopathological and molecular characteristics of with hypermutant lung cancer identify economical, simple complementary method for predicting TMB immunotherapy responses. In total, 1,000 were randomly selected, their samples submitted next‑generation sequencing, status reviewed. threshold hypermutation was set 17.24 mutations (muts)/Mb....
Abstract Background Adenocarcinoma, the most common form of lung cancer, is one main human malignant tumors. In this paper, we focus on effect antitumor activity cytokine‐induced killer ( CIK ) cells adenocarcinoma cell line A549. Methods were obtained by inducing peripheral blood mononuclear with recombinant (rh) interferon‐gamma, monoclonal anti‐ CD3 antibody, rh interleukin (IL) ‐1alpha, and rhIL ‐2, which added into culture. A549 viability was determined using MTS assay. Flow cytometry...
Cytokine-induced killer (CIK) cells were isolated and proliferation from human peripheral blood cultured in appropriate growth medium. The biological characteristics of CIK further determined by the characterization surface markers flow cytometry. inhibited lung adenocarcinoma NCL-H157 cells. Vascular endothelial factor (VEGF) expression was down-regulated co-cultured with western blotting analysis. Furthermore, comparison untreated CIK, had a lower capacity. We proposed that pharmacological...
Objective To analyze the clinical value of combined detection tuberculous T cell enzyme-linked immuno spot assay (T-SPOT.TB) and adenosine deaminase (ADA) in pleurisy patients different ages. Methods From February 2014 to 2018, three hundred thirty-six with pleural effusion were admitted Hebei Thoracic Hospital.Among them, two fifty five cases diagnosed as 81 non-tuberculous pleurisy.The divided into groups according their age.The younger group (214 cases) was 16-59 years old older...
e21646 Background: Identifying targetable genetic variants may help maximize clinical benefit of non-small cell lung cancer (NSCLC). Here, we retrospectively analyzed the next-generation sequencing (NGS) for NSCLC in routine practice. Methods: A total 59 patients were enrolled study from Jun. 2018 to Dec. 2019. Formalin-fixed paraffin-embedded tissues samples collected and sequenced by NGS, which detects single-nucleotide variants, small insertions/deletions, rearrangements, copy-number...
e15255 Background: Tumor mutation burden (TMB) has been confirmed to predict the sensitivity immunotherapy across multiple tumor types. Multiple genetic factors have increase level of TMB, such as mutations in DNA damage repair (DDR) genes, POLE/POLD1, and high microsatellite instability (MSI). However, extent that these contribute hypermutation lung cancer not fully investigated. Methods: We retrospectively reviewed profiles 1000 patients (pts) who underwent 1021-panel matched tumor-normal...