A5102871939- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Aquaculture Nutrition and Growth
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Research Studies
- Animal Nutrition and Physiology
- Aquaculture disease management and microbiota
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Fungal Infections and Studies
- Insect Utilization and Effects
- Colorectal and Anal Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Probiotics and Fermented Foods
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
Fujian Medical University
2014-2024
Zhangzhou Municipal Hospital of Fujian Province
2014-2024
Shenzhen Second People's Hospital
2022
National Natural Science Foundation of China
2019
Weatherford College
2019
Ningbo University of Technology
2006-2014
Xiaomi (China)
2006
Abstract Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase 2 trial (NCT04195828), patients with adenocarcinoma (clinical T2-4N + M0) were randomly assigned (1:1) to receive neoadjuvant camrelizumab apatinib combined nab-paclitaxel plus S-1 (CA-SAP) or chemotherapy SAP alone (SAP) for 3 cycles. The primary endpoint was major...
<h3>Importance</h3> Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine are rare pathological types of gastric cancer, there is a lack multicenter studies comparing the prognosis recurrence patterns carcinoma, adenocarcinoma. <h3>Objective</h3> To compare differences in long-term survival among <h3>Design, Setting, Participants</h3> This cohort study included patients with resectable at 23 hospitals China from January 2006 to December 2016. In addition, adenocarcinoma were...
The safety and efficacy of neoadjuvant immunochemotherapy (nICT) for locally advanced gastric cancer (LAGC) remain controversial.
<h3>Importance</h3> Apatinib is a novel treatment option for chemotherapy-refractory advanced gastric cancer (GC), but it has not been evaluated in patients with locally GC. <h3>Objective</h3> To investigate the effectiveness and safety of apatinib combined S-1 plus oxaliplatin (SOX) as neoadjuvant <h3>Design, Setting, Participants</h3> This multicenter, prospective, single-group, open-label, phase 2 nonrandomized controlled trial was conducted 10 centers southern China. Patients M0 either...
Lactobacilli should resist stress environments in industry process and gastrointestinal tract before exerting their beneficial effects. To explore the possible stabilizers probiotic products, prebiotic oligosaccharides were investigated.We investigated effect of four selected on survival Lactobacillus plantarum L. acidophilus to simulated conditions. It was found that tolerance lactobacilli artificial juice, heat treatment phenol solution obviously enhanced fructo-oligosaccharides (FOS)...
The long-term survival of patients with laparoscopic total gastrectomy combined spleen-preserving splenic hilar lymphadenectomy (LSTG) for advanced upper-third gastric cancer (AUTGC) and the association lymph node (LN-10) metastasis remain controversial.To evaluate outcomes LSTG value index LN-10 AUTGC.The Chinese Laparoscopic Gastrointestinal Surgery Study 4 (CLASS-04) was a prospective, multicenter, single-arm trial that involved 19 centers in China. A 251 eligible clinical stage T2, T3,...
Laparoscopic radical gastrectomy is widely used, and perioperative complications have become a highly concerned issue.
Background: The efficacy of laparoscopic completion total gastrectomy (LCTG) for remnant gastric cancer (RGC) remains controversial. Methods: primary outcome was postoperative morbidity within 30 days after surgery. Secondary outcomes included 3-year disease-free survival (DFS), overall (OS), and recurrence. Inverse probability treatment weighted (IPTW) used to balance the baseline between LCTG OCTG. Results: Final analysis 46 patients with RGC who underwent at FJMUUH June 2016 2020....
Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumorigenesis and development. Although the low expression of miR-125a-5p gastric cancer has been reported, underlying mechanism remains unknown. In current study, was verified paired tissues adjacent non-tumour tissues. Furthermore, GC islands region were hypermethylated tumour And hypermethylation negatively correlated with expression. Target gene screening showed histone methyltransferase Suv39H1 one potential...
Abstract The present study was designed to evaluate the dynamic survival and recurrence of remnant gastric cancer (RGC) after radical resection provide a reference for development personalized follow‐up strategies. A total 298 patients were analyzed their 3‐year conditional overall (COS3), disease‐specific (CDSS3), corresponding pattern changes, associated risk factors. 5‐year (OS) (DSS) entire cohort 41.2% 45.8%, respectively. COS3 CDDS3 RGC who survived 5 years 84.0% 89.8%, in with...
Abstract Gastric cancer peritoneal metastases (GCPM) is a leading cause of GC‐related death. Early detection GCPM critical for improving the prognosis advanced GC. Differentially expressed genes (DEGs) were identified in GSE62254 database to distinguish between and non‐GCPM. The gastric signature (GCPMs) was developed using DEGs. We analysed effectiveness GCPMs as indicators prognosis, chemotherapy, immune therapy response GC patients. Subsequently, we correlation microenvironment well...
Abstract Altered expression of microRNA (miRNA) is strongly implicated in gastric cancer (GC). Here, we demonstrated a decreased miRNA‐329 GC. Then explored the regulatory mechanisms responsible for its effect on GC cells. tissues and their adjacent non‐tumor were collected. Complete follow‐up was updated. A series inhibitors, mimics, siRNA against KDM1A introduced to validate miR‐497 BGC‐823 Quantitative real‐time polymerase chain reaction (qRT‐PCR) western blot assay employed evaluating...