A5085786259- Physiological and biochemical adaptations
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Aquatic Ecosystems and Phytoplankton Dynamics
- Pancreatic function and diabetes
- Planarian Biology and Electrostimulation
- Genetics, Aging, and Longevity in Model Organisms
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
University of Alberta
2017-2019
Despite the fact that skeletal muscle insulin resistance is hallmark of type-2 diabetes mellitus (T2DM), inflexibility in substrate energy metabolism has been observed other tissues such as liver, adipose tissue, and heart. In heart, structural functional changes ultimately lead to diabetic cardiomyopathy. However, little known about early biochemical cause cardiac metabolic dysregulation dysfunction. We used a dietary model fructose-induced T2DM (10% fructose drinking water for 6 weeks)...
As the world's climate changes, life faces an evolving thermal environment. Mitochondrial oxidative phosphorylation (OXPHOS) is critical to ensure sufficient cellular energy production, and it strongly influenced by temperature. The thermally-induced changes regulation specific steps within OXPHOS process are poorly understood. In our study, we used eurythermal species of planarian Dugesia tigrina study sensitivity at 10, 15, 20, 25, 30°C. We conducted cold acclimation experiments where...