A5100922273- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Quinazolinone synthesis and applications
- Enzyme Structure and Function
- Pharmacogenetics and Drug Metabolism
- Multicomponent Synthesis of Heterocycles
- Protein Structure and Dynamics
- Synthesis and biological activity
- Amino Acid Enzymes and Metabolism
- Analytical Chemistry and Chromatography
- Photosynthetic Processes and Mechanisms
- Synthesis and Biological Evaluation
- Electrochemical sensors and biosensors
- Metalloenzymes and iron-sulfur proteins
- Plant biochemistry and biosynthesis
- thermodynamics and calorimetric analyses
- Tryptophan and brain disorders
- Click Chemistry and Applications
- Supercapacitor Materials and Fabrication
- Memory and Neural Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Rabbits: Nutrition, Reproduction, Health
- Synthesis and Reactions of Organic Compounds
- Metal complexes synthesis and properties
- Natural product bioactivities and synthesis
Chinese Academy of Sciences
2024-2025
Shanghai Institute of Materia Medica
2024-2025
Obstetrics and Gynecology Hospital of Fudan University
2025
Huashan Hospital
2024
Fudan University
2024
University of Chinese Academy of Sciences
2024
Shandong University
2021-2022
Xinxiang Medical University
2020
First Affiliated Hospital of Xinxiang Medical University
2020
Zhejiang University
2012-2016
Transaminase biocatalysis shows immense potential in industrial applications, and optimizations of both proteins processes are great importance.
Quinazoline derivatives were obtained <italic>via</italic> CuO nanoparticles catalyzed reaction of <italic>N</italic>-arylamidines and aromatic alcohols in air.
N-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds selectively targeting with antidepressant effects been identified. Here, we present YY-23, a compound that inhibits GluN2C- or GluN2D-containing NMDARs. Cryo-EM analysis revealed YY-23 binds to the transmembrane domain GluN2D subunit. primarily affects on...
Abstract Background Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, traditional biotransformation is insufficient to meet fast-growing pharmaceutical demands. Microbial synthetic biology offers promising strategies for synthesis diversification glycosides. Results In this study, two efficient UDP-glucosyltransferases (UGTs) (UGT85A1 RrUGT3) origin, that are capable recognizing...
Three series of 4-morpholinothieno[3,2-d]pyrimidine derivatives containing arylmethylene hydrazine moiety (11a–f, 13a–k and 15a–h) were synthesized their chemical structures as well the relative stereochemistry confirmed. The compounds evaluated for cytotoxicity against three cancer cell lines (H460, HT-29, MDA-MB-231). Most them exhibited moderate to significant high-selectivity one or more lines, especially 11c, 13b, 15f 15g possessing dramatically increased compared with positive...
ABSTRACT Aromatic interactions specific to aryl radicals were introduced into two esterases, BioH from Escherichia coli and RspE Rhodobacter sphaeroides control their enantioselectivity in the asymmetric hydrolysis of prochiral glutaric acid diesters. As a result, enantiomeric excess (ee) S‐ product dimethyl 3‐phenylglutarate was increased 25% (BioH wild type) 96% (B_L83F/L86F) 13% (RspE >99% (R_Y27R), respectively, while another variant R_M121F gave reversed ee 50% ( R ‐product). Similar...
<sc>d</sc>-Fructose-6-phosphate aldolase A (FSAA) from<italic>Escherichia coli</italic>was engineered for enhanced catalytic efficiency towards cinnamaldehyde.
Abstract Two novel coordination polymers based on Cu(II) ions as the metal nodes, {Cu(pydc)(2,2‐bpy)(DMF)} n ( 1 , H 2 pydc=3,5‐pyridinedicarboxylate, 2,2‐bpy=2,2‐bipyridine) and {[Cu(H O) (H imdc) ](H O)} 3 imdc=1H‐imidazole‐4,5‐dicarboxylic acid) have been synthesized via hydrothermal or solvothermal conditions characterized by techniques of elemental analysis, powder X‐ray diffraction (PXRD) well analysis single‐crystal diffraction. Furthermore, anti‐tumor activities compounds against...
Anthelmintics are drugs used for controlling pathogenic helminths in animals and plants. The natural compound betaine the recently developed synthetic monepantel both anthelmintics that target acetylcholine receptor ACR-23 its homologs nematodes. Here, we present cryo-electron microscopy structures of apo, betaine-bound, betaine- monepantel-bound states. We show forms a homo-pentameric channel, similar to some other pentameric ligand-gated ion channels (pLGICs). While molecules bound...
Abstract Most of the synthesized compounds show moderate to significant cytotoxicity and high selectivity against one or more cell lines.
Selective oxidation of C-H bonds in alkylphenols holds great significance for not only structural derivatization pharma- and biomanufacturing but also biological degradation these toxic chemicals environmental protection. A unique chemomimetic biocatalytic system using enzymes from a p-cresol biodegradation pathway has recently been developed. As the central biocatalyst, cytochrome P450 monooxygenase CreJ oxidizes diverse p- m-alkylphenol phosphates with perfect stereoselectivity at...
Abstract CuO nanoparticles are found to be efficient catalysts for the reaction of N‐arylamidines (I) and (IV) aromatic aldehydes (II) or benzyl alcohols (VI) afford quinazolines (III) (V), resp., in good high yields.