A5100379424- Advanced ceramic materials synthesis
- Neuroscience and Neuropharmacology Research
- Advanced materials and composites
- Microwave Dielectric Ceramics Synthesis
- Memory and Neural Mechanisms
- MXene and MAX Phase Materials
- Nuclear materials and radiation effects
- ZnO doping and properties
- Metal and Thin Film Mechanics
- Electromagnetic wave absorption materials
- Anesthesia and Neurotoxicity Research
- Underwater Acoustics Research
- Luminescence Properties of Advanced Materials
- Ion Channels and Receptors
- Stress Responses and Cortisol
- Dielectric properties of ceramics
- Ga2O3 and related materials
- Phytochemistry and Biological Activities
- Geophysical Methods and Applications
- Advanced Antenna and Metasurface Technologies
- Semiconductor materials and devices
- Underwater Vehicles and Communication Systems
- Metamaterials and Metasurfaces Applications
- Photorefractive and Nonlinear Optics
- Titanium Alloys Microstructure and Properties
University of Chinese Academy of Sciences
2019-2025
Shanghai Institute of Materia Medica
2019-2025
Chinese Academy of Sciences
2019-2025
Shanghai First Maternity and Infant Hospital
2024
Tongji University
2024
Shanghai Institute of Ceramics
2022-2024
Anhui Polytechnic University
2023-2024
N-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds selectively targeting with antidepressant effects been identified. Here, we present YY-23, a compound that inhibits GluN2C- or GluN2D-containing NMDARs. Cryo-EM analysis revealed YY-23 binds to the transmembrane domain GluN2D subunit. primarily affects on...
Clinical studies have demonstrated that exposure to the inhalational general anesthetic nitrous oxide (N2O) produces antidepressant effects in depressed patients. However, mechanisms underlying of N2O remain largely unknown. Neuronal nitric synthase (nNOS) – mediated (NO) synthesis is essential for brain function and underlies molecular many neuromodulators. We hypothesized activation nNOS/NO pathway medial prefrontal cortex (mPFC) might mediate N2O. In this study, we revealed repeated...
Five unusual dimers of ent-labdane diterpenoids (1–5) were isolated and identified from Andrographis paniculata, a famous medicinal plant. Bisandrographolide E (1) represents the first example labdane dimer possessing an unprecedent tricyclic system that comprised spiroketal moiety fused with ketal-γ-lactone unit in its skeleton. Its biosynthetically related intermediates, all four stereoisomers at C-12 C-15′, bisandrographolides F (2, new compound) A–C (3–5), obtained same time. The steric...
Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, has been extensively studied for its potential therapeutic effects on various central nervous system (CNS) disorders, including epilepsy, chronic pain, Parkinson’s disease, and stress-related neuropsychiatric disorders. However, pharmacological mechanisms of CBD have not fully elucidated due to complexity their targets. In this study, we reported that transient receptor canonical 4 (TRPC4) channel,...
A geoacoustic inversion of sediment parameters based on passive synthetic aperture for a moving autonomous underwater vehicle (AUV) and source emitting continuous tone signal is proposed in this paper. An accurate representation received receiver the time domain derived Doppler-shifted field. The depth-dependent Green's function obtained by performing Hankel transformation pressure Geoacoustic are determined using grid search scheme ambiguity function, which constructed Bartlett matched...
Allostery is a fundamental element during channel gating in response to an appropriate stimulus by which events occurring at one site are transmitted distal sites regulate activity. To address how binding of the first Ca2+ ion eight chemically identical subunits facilitates other Ca2+-binding MthK, Ca2+-gated K+ containing conserved ligand-binding RCK domain, we analysed large collection MthK structures and performed corresponding thermodynamic electrophysiological measurements. These...