A5034604512- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Amino Acid Enzymes and Metabolism
- Advanced NMR Techniques and Applications
- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- Treatment of Major Depression
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- RNA regulation and disease
- Autoimmune Neurological Disorders and Treatments
- Photoreceptor and optogenetics research
- Nicotinic Acetylcholine Receptors Study
- Connexins and lens biology
- Autism Spectrum Disorder Research
- Genetic Syndromes and Imprinting
- Neuroendocrine regulation and behavior
- Anesthesia and Neurotoxicity Research
- Hearing, Cochlea, Tinnitus, Genetics
- Asymmetric Synthesis and Catalysis
- Biochemical Analysis and Sensing Techniques
- Photochromic and Fluorescence Chemistry
- Parathyroid Disorders and Treatments
University of Chinese Academy of Sciences
2018-2025
Center for Excellence in Brain Science and Intelligence Technology
2018-2025
Chinese Academy of Sciences
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2025
Beijing Normal University
2025
Sun Yat-sen University
2025
Tianjin University of Traditional Chinese Medicine
2025
Shanghai Institutes for Biological Sciences
2018-2022
Vollum Institute
2016
Oregon Health & Science University
2016
Chimeric antigen receptor (CAR) T-cell therapy has exhibited remarkable efficacy in the treatment of haematological malignancies, yet its application solid tumours is hindered by immunosuppressive tumour microenvironment (TME). In this study, a novel SS1-TREM1/DAP12-BB CAR-T cell was devised to target ovarian cancer and further engineered co-express dominant-negative TGF-β 2 (DNR) combat exhaustion TME. The incorporation DNR effectively blocked signalling, thereby enhancing survival...
Connexins and pannexins are two protein families that play an important role in cellular communication. Pannexin 1 (PANX1), one of the members pannexin family, is a channel protein. It glycosylated forms three species, GLY0, GLY1, GLY2. Here, we describe four independent which mutations
Ligand-gated ion channels (LGICs) mediate fast synaptic transmission in the CNS. Typically, these membrane proteins are multimeric complexes associating several homologous subunits around a central pore. Because of large repertoire within each family, LGICs exist vivo as multiple subtypes that differ subunit composition and functional properties. Establishing specific properties individual receptor remains major goal field neuroscience molecular pharmacology. However, isolating subtype...
N-methyl-D-aspartate (NMDA) receptors are critical for synaptic development and plasticity. While glutamate is the primary agonist, protons can modulate NMDA receptor activity at synapses during vesicle exocytosis by mechanisms that unknown. We used cryo-electron microscopy to solve structures of human GluN1-GluN2A pH 7.8 6.3. Our demonstrate proton sensor predominantly resides in N-terminal domain (NTD) GluN2A subunit reveal allosteric coupling mechanism between channel gate. Under high-pH...
Significance The design of protein receptors responsive to light stimuli has wide-ranging applications in structure–function studies and optogenetics. We present here the a light-sensitive NMDA receptor by introducing through genetic-code expansion photoreactive moiety carried single unnatural amino acid. form glutamate-gated ion channels that are essential mediators synaptic plasticity associated with learning memory. By exploring molecular mechanisms subunit dependence light-induced...
The cerebral cortex and hippocampus are crucial brain regions for learning memory, which depend on activity-induced synaptic plasticity involving N-methyl-ᴅ-aspartate receptors (NMDARs). However, subunit assembly molecular architecture of endogenous NMDARs (eNMDARs) in the remain elusive. Using conformation- subunit-dependent antibodies, we purified eNMDARs from adult rat hippocampus. Three major subtypes GluN1-N2A-N2B, GluN1-N2B, GluN1-N2A were resolved by cryoelectron microscopy (cryo-EM)...
Background: Peripheral artery disease (PAD) is a high-risk vascular condition, and remodeling has become promising therapeutic approach. Paeoniflorin (PF) the main bioactive compound in roots of Paeonia lactiflora Pall, which commonly used to treat range cardiovascular disorders. However, mechanisms underlying ameliorating effects PF on PAD remain unclear. Therefore, purpose this study was explore efficiency determine its mechanisms. Methods: The blood flow mice detected with laser Doppler...
Abstract Amorphous MOFs have attracted more attentions due to their excellent adsorption performance. However, the transformation of crystalline MOF into amorphous often requires harsh conditions, and simple scalable amorphization strategies are still lacking. In this work, via a solvent‐assisted evaporation strategy is synthesized. The results show that gf BNU‐1(Zn) BNU‐1(Cd) glass foams with short‐range ordered but long‐range disordered atomic structure foam‐like multistage pore display...
N-methyl-d-aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and GluN2 subunits (2A-2D), which determine their pharmacological properties. Few compounds selectively targeting with antidepressant effects been identified. Here, we present YY-23, a compound that inhibits GluN2C- or GluN2D-containing NMDARs. Cryo-EM analysis revealed YY-23 binds to the transmembrane domain GluN2D subunit. primarily affects on...