A5079657073- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Neurobiology and Insect Physiology Research
- Hypothalamic control of reproductive hormones
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Spinal Cord Injury Research
- Evolutionary Psychology and Human Behavior
- Neuroscience of respiration and sleep
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Neural Networks Stability and Synchronization
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neonatal and fetal brain pathology
- Photoreceptor and optogenetics research
- Schizophrenia research and treatment
- Diabetes Treatment and Management
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
Center for Excellence in Brain Science and Intelligence Technology
2018-2025
Chinese Academy of Sciences
2018-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2025
University of Chinese Academy of Sciences
2019-2024
Shanghai Institutes for Biological Sciences
2018
The medial preoptic area (mPOA) differs between males and females in nearly all species examined to date, including humans. Here, using fiber photometry recordings of Ca2+ transients freely behaving mice, we show ramping activities the mPOA that precede correlate with sexually dimorphic display male-typical mounting female-typical pup retrieval. Strikingly, optogenetic stimulation elicits similar retrieval both females. Furthermore, by means recording, ablation, activation, inhibition,...
Despite being innate, displays of aggression are influenced by cortical activities. Here, using Vglut1 as a marker for inputs from structures, we identify small population excitatory neurons located in the posterior amygdala (PA) that project to ventrolateral division ventromedial nucleus hypothalamus (VMHvl), region critically regulates territorial aggression. Indeed, activities PA Vglut1+ (PAVglut1) neurons, analyzed post hoc c-Fos expression, differentiate trials which attacks occur, or...
<title>Abstract</title> The hypothalamus is critical for regulating behaviors essential survival and locomotion, but how it integrates internal needs transmits locomotion commands to the spinal cord (SC) remains unclear. We found that glutamatergic neurons in lateral hypothalamic area (LHA) are motivated locomotor activity. Using single-neuron projectome analysis, trans-synaptic tracing, optogenetic manipulation, we showed LHA facilitates during food seeking via pontine oral part (PnO)...
Abstract The hypothalamus plays a vital role in coordinating essential neuroendocrine, autonomic, and somatomotor responses for survival reproduction. While previous studies have explored population-level projections of hypothalamic neurons, the specific innervation patterns individual axons remain unclear. To understand organization axon projections, we conducted comprehensive reconstruction single-cell projectomes from 7,180 mouse neurons expressing neuropeptides. Our analysis identified...
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Survey-based evidence suggests that men experience a distinct post-ejaculation affective state1,2, marked by intense pleasure sometimes compared to the euphoric rush from intravenous injection of opioid drugs such as heroin3. However, intrinsic neural circuit mechanisms underlying ejaculation-triggered state remain unclear. Here, we discovered Calbindin1-expressing (Calb1+) neurons in preoptic area (POA) hypothalamus, an evolutionarily conserved regulatory region for male mating behavior4,...
<title>Abstract</title> Survey-based evidence suggests that men experience a distinct post-ejaculation affective state1,2, marked by intense pleasure sometimes compared to the euphoric rush from intravenous injection of opioid drugs such as heroin3. However, intrinsic neural circuit mechanisms underlying ejaculation-triggered state remain unclear. Here, we discovered Calbindin1-expressing (Calb1+) neurons in preoptic area (POA) hypothalamus, an evolutionarily conserved regulatory region for...
SUMMARY The hypothalamus is critical for regulating behaviors essential survival and locomotion, but how it integrates internal needs transmits locomotion commands to the spinal cord (SC) remains unclear. We found that glutamatergic neurons in lateral hypothalamic area (LHA) are motivated locomotor activity. Using single-neuron projectome analysis, trans-synaptic tracing, optogenetic manipulation, we showed LHA facilitates during food seeking via pontine oral part (PnO) projection neurons,...
Despite extensive characterization, elucidating hypothalamic neuronal subtypes controlling essential behaviors remain challenging. To probe the subtype of medial preoptic area Esr1+ (mPOAEsr1+) neurons that critically regulate male mating, we deployed a single-cell projectome approach and reconstructed axon projections individual mPOA throughout brain. Based on their projection patterns, clustered into four distinctive subtypes: local, intra-hypothalamic, amygdala-, long-range projecting....
Despite being innate, display of aggression is influenced by cortical activities. Here, using Vglut1 as a marker for inputs from structures, we identified small population excitatory neurons located in the posterior amygdala (PA) that project to ventrolateral division ventromedial nucleus hypothalamus (VMHvl), region critically regulates territorial aggression. Indeed, activities PAVglut1+ (PAVglut1) neurons, analyzed post-hoc c-Fos expression, unequivocally differentiated trials which...
Abstract The medial preoptic area (mPOA) of the hypothalamus is sexually dimorphic and controls display male mating parental care. Yet, despite extensive characterization sex differences in mPOA, we know surprisingly little about whether or how female mPOA neurons differ electrophysiologically, which relate more directly to neuronal firing behavioral pattern generation. In this study, performed whole-cell patch clamp recordings acute brain slices cut from virgin adult mice, compared total 29...
Despite being innate, display of aggression is influenced by cortical activities. Here, using Vglut1 as a marker for inputs from structures, we identified small population excitatory neurons located in the posterior amygdala (PA) that projects to ventrolateral division ventromedial nucleus hypothalamus (VMHvl), region critically regulate territorial aggression. Indeed, activities PA Vglut1+ (PA ) neurons, analyzed post-hoc c-Fos expression, unequivocally differentiate trials which attacks...