A5072319870- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Autoimmune Neurological Disorders and Treatments
- Chemical Synthesis and Analysis
- Magnesium in Health and Disease
- Cytomegalovirus and herpesvirus research
- Molecular Sensors and Ion Detection
- Coordination Chemistry and Organometallics
- RNA and protein synthesis mechanisms
Antibodies against N-methyl-d-aspartate receptors (NMDARs) are most frequently detected in persons with autoimmune encephalitis (AE) and used as diagnostic biomarkers. Elucidating the structural basis of monoclonal antibody (mAb) binding to NMDARs would facilitate development targeted therapy for AE. Here, we reconstructed nanodiscs containing green fluorescent protein-fused label sort individual immune B cells from AE further cloned identified mAbs NMDARs. This allowed cryo-electron...
Abstract N -Methyl-D-Aspartate (NMDA) receptors are essential for many brain functions. These heterotetramers typically comprising two GluN1 subunits and GluN2 subunits. The latter could alternate among four subtypes (N2A-N2D) determine the functional diversity of NMDA 1, 2 . For example, containing N2C or N2D exhibit 50-fold lower channel open probability (Po) than those N2A (ref. 3–5 ). Structures N2A- N2B-containing have been extensively characterized, providing molecular basis...