About
Contact & Profiles
A5092401836
Research Areas
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Renal and related cancers
- Nanowire Synthesis and Applications
Chimeric antigen receptor (CAR) T-cell therapy has exhibited remarkable efficacy in the treatment of haematological malignancies, yet its application solid tumours is hindered by immunosuppressive tumour microenvironment (TME). In this study, a novel SS1-TREM1/DAP12-BB CAR-T cell was devised to target ovarian cancer and further engineered co-express dominant-negative TGF-β 2 (DNR) combat exhaustion TME. The incorporation DNR effectively blocked signalling, thereby enhancing survival...
10.1111/imm.13888
article
EN
Immunology
2025-01-02
10.1007/s12032-023-02084-9
article
EN
Medical Oncology
2023-07-05
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