Taosha Gao
A5102707054- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
Center for Excellence in Brain Science and Intelligence Technology
2024-2025
Chinese Academy of Sciences
2024-2025
Mapping single-neuron projections is essential for understanding brain-wide connectivity and diverse functions of the hippocampus (HIP). Here, we reconstructed 10,100 projectomes mouse HIP classified 43 projectome subtypes with distinct projection patterns. The number targets axon-tip distribution depended on soma location along longitudinal transverse axes. Many were enriched in specific subdomains defined by spatial transcriptomic profiles. Furthermore, delineated comprehensive wiring...
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species specialized features in humans remain poorly understood. Here we performed machine learning-augmented analysis of published single-cell RNA-sequencing datasets identified macaque imGCs with transcriptome-wide immature neuronal characteristics. Our cross-species comparisons among humans, monkeys, pigs, mice showed few...