A5084554132- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Photorefractive and Nonlinear Optics
- Photonic and Optical Devices
- Astrophysics and Cosmic Phenomena
- Diet and metabolism studies
- Advanced Fiber Laser Technologies
- Dark Matter and Cosmic Phenomena
- Neuroscience and Neuropharmacology Research
- Gamma-ray bursts and supernovae
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Optical Imaging and Spectroscopy Techniques
- Neuroendocrine regulation and behavior
- Retinal Development and Disorders
- Neuroscience and Neural Engineering
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Traditional Chinese Medicine Analysis
- Biochemical Analysis and Sensing Techniques
- Animal Behavior and Welfare Studies
University of Calgary
2015-2025
Alberta Children's Hospital
2015-2025
Institute of High Energy Physics
2021-2025
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2025
Wuhan University
2025
Lanzhou University
2021-2024
Allen Institute for Brain Science
2021-2024
Gansu Great Wall Electrical and Electronics Engineering Research Institute
2024
Nanyang Normal University
2023
Abstract We present the first catalog of very-high-energy and ultra-high-energy gamma-ray sources detected by Large High Altitude Air Shower Observatory. The was compiled using 508 days data collected Water Cherenkov Detector Array from 2021 March to 2022 September 933 recorded Kilometer Squared 2020 January September. This represents main result most sensitive large coverage survey sky above 1 TeV, covering decl. −20° 80°. In total, contains 90 with an extended size smaller than 2° a...
Abstract The complex relationship between specific hippocampal oscillation frequency deficit and cognitive dysfunction in the ischemic brain is unclear. Here, using a mouse two-vessel occlusion (2VO) cerebral ischemia model, we show that visual stimulation with 40 Hz light flicker drove CA1 slow gamma restored 2VO-induced reduction power theta-low phase-amplitude coupling, but not those of high gamma. Low lights at 30 Hz, 50 10 80 arrhythmic light, were protective against degenerating...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a new concept, proposed in 2020; however, its applicability Asia populations has yet to be evaluated. Therefore, we aimed compare the difference epidemiological and clinical characteristics between MAFLD non-alcoholic (NAFLD) among Asian populations.
The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying northern γ-ray sky energies above 10 TeV with unprecedented sensitivity. observations have long been one most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by decays heavy particles. In this Letter, we present first analysis LHAASO-KM2A, using 340 days data from 1/2-KM2A and 230 3/4-KM2A. Several regions interest are used to search a signal...
Abstract Autism spectrum disorder (ASD) has been hypothesized to be a result of altered connectivity in the brain. Recent imaging studies suggest accelerated maturation white matter young children with ASD, underlying mechanisms unknown. Myelin is an integral part and critical for connectivity; however, its role ASD remains largely unclear. Here, we investigated myelin development model idiopathic BTBR mice. Magnetic resonance revealed that fiber tracts frontal brain mice had increased...
Given that prebiotics have been shown to improve gut microbiota composition, gastrointestinal symptoms and select behaviors in autism spectrum disorder (ASD), we hypothesized prebiotic supplementation would sociability, communication, repetitive a murine model of ASD. We also examined the effect synbiotic (probiotic + prebiotic). Juvenile male BTBR mice were randomized to: (1) control; (2) probiotic (1 × 1010 CFU/d Lactobacillus reuteri RC-14®; now known as Limosilactobacillus reuteri); (3)...
Automated behavior quantification in socially interacting animals requires accurate tracking. While many methods have been very successful and highly generalizable to different settings, issues of mistaken identities lost information on key anatomical features are common, although they can be alleviated by increased human effort training or post-processing. We propose a markerless video-based tool simultaneously track two mice the same appearance controlled settings for quantifying behaviors...
Abstract Background Autism is one of the most prevalent neurodevelopmental disorders worldwide. It predominantly idiopathic, while syndromic forms have also been identified. Fragile X Syndrome (FXS) common monogenic cause autism and intellectual disability. No cure currently exists for or FXS, drug development has suffered many failures in clinical trials, which were based on promising preclinical findings. Thus, effective translational biomarkers that bridge animal human studies are...
SignificanceSeveral miniaturized optical neuroimaging devices for preclinical studies mimicking benchtop instrumentation have been proposed in the past. However, they are generally relatively large, complex, and power-hungry, limiting their usability long-term measurements freely moving animals. Further, there is limited research development of algorithms to analyze signals.AimWe aim develop a cost-effective, easy-to-use intrinsic monitoring system (TinyIOMS) that can be reliably used record...
Background: Auditory hypersensitivity is a prominent symptom in Fragile X syndrome (FXS), the most prevalent monogenic cause of autism and intellectual disability. FXS arises through loss protein encoded by FMR1 (Fragile Messenger Ribonucleoprotein 1) gene, FMRP, required for normal neural circuit excitability. In brainstem, FMRP necessary development acoustic reactivity, its has been implicated audiogenic seizures (AGS) Fmr1 knockout (KO) mice, modelling auditory patients. Purpose: The...
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental condition characterized by impaired social communication and interactions, restricted, repetitive activities or interests. Alterations in network connectivity memory function are frequently observed autism patients, often involving the hippocampus. However, specific changes during early brain development leading disrupted functioning remain largely unclear. Here, we investigated of dendritic arbor...
Accumulation of amyloid-β (Aβ) peptide in the brain is a central hallmark Alzheimer's disease (AD) and thought to be cause observed neurodegeneration. Many animal models have been generated that overproduce Aβ yet do not exhibit clear neuronal loss, questioning this hypothesis. We previously developed an vivo mouse model expresses humanized amyloid precursor protein (hAPP) olfactory sensory neurons (OSNs) showing robust apoptosis dysfunction by 3 weeks age, which consistent with early OSN...
Abstract Fragile X Syndrome results from a loss of Mental Retardation Protein (FMRP). We now show that FMRP is member Cav3-Kv4 ion channel complex known to regulate A-type potassium current in cerebellar granule cells produce mossy fiber LTP. Mossy LTP absent Fmr1 knockout (KO) mice but restored by FMRP(1-297)- tat peptide. This peptide further rapidly permeates the blood-brain barrier enter across cerebellar-cortical axis restores balance protein translation for at least 24 h and...
Amyloid precursor protein (APP) has long been linked to the neurodegeneration of Alzheimer's disease (AD), but associated cell death difficult capture in vivo , and role APP effecting neuron loss is still unclear. Olfactory dysfunction an early symptom AD with amyloid pathology olfactory epithelium correlating well brain patients. As sensory neurons (OSNs) regenerate continuously immature mature OSNs coexisting same epithelium, we sought use this unique system study APP-induced...
Neural circuits maintain a precise organization that is vital for normal brain functions and behaviors, but become disrupted during neurological disease. Understanding the connection between wiring accuracy function to measure disease progression or recovery has been difficult because of complexity behavioral circuits. The olfactory system maintains well-defined neural connections regenerate throughout life. We previously established reversible in vivo model Alzheimer's by overexpressing...