A5070686051- GaN-based semiconductor devices and materials
- RNA modifications and cancer
- ZnO doping and properties
- Ga2O3 and related materials
- Acoustic Wave Resonator Technologies
- Epigenetics and DNA Methylation
- Metal and Thin Film Mechanics
- Semiconductor Quantum Structures and Devices
- Genetic Syndromes and Imprinting
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Kruppel-like factors research
- Astrophysics and Cosmic Phenomena
- Cancer-related gene regulation
- Fluid Dynamics and Mixing
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- High-Voltage Power Transmission Systems
- Signaling Pathways in Disease
- Fluid Dynamics and Heat Transfer
- Pharmacy and Medical Practices
- Hematopoietic Stem Cell Transplantation
- NF-κB Signaling Pathways
- Healthcare Education and Workforce Issues
Shaanxi Normal University
2020-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Shandong University
2012-2024
Suzhou Institute of Nano-tech and Nano-bionics
2020-2023
Chinese Academy of Sciences
1998-2023
Ludong University
2016-2021
Qiqihar Medical University
2016-2021
Shanxi Normal University
2013-2021
Tianjin University
2014-2020
Dalian Naval Academy
2020
Tungsten carbides, featured by their Pt-like electronic structure, have long been advocated as potential replacements for the benchmark Pt-group catalysts in hydrogen evolution reaction. However, tungsten-carbide usually exhibit poor alkaline HER performance because of sluggish desorption behavior and possible corrosion problem tungsten atoms produced hydroxyl intermediates. Herein, we report synthesis atomic clusters anchored on P-doped carbon materials via a thermal-migration strategy...
Ferroptosis is a form of iron-dependent programmed cell death, which distinct from apoptosis, necrosis, and autophagy. Mitochondria play critical role in initiating amplifying ferroptosis cancer cells. Voltage-Dependent Anion Channel 1 (VDAC1) embedded the mitochondrial outer membrane, exerts roles regulation ferroptosis. However, mechanisms VDAC1 oligomerization regulating are not well elucidated. Here, we identify that binding protein V-Set Transmembrane Domain Containing 2 Like (VSTM2L),...
// Chao Liu 1, 2, * , En-Dong Yun-Xiao Meng 3, Xiao-Ming Dong 4 Ya-Lan Bi 3 Huan-Wen Wu Yan-Chao Jin 2 Ke Zhao Jian-Jie Li 5 Miao Yu Yi-Qun Zhan Hui Chen Chang-Hui Ge Yang and Chang-Yan 1 An Medical University, Hefei, 230032, China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Institute Radiation Medicine, Beijing, 100850, Department Pathology, Peking Union College Hospital, Chinese Academy Sciences College, Tsinghua 100730, Tianjin School Chemical Engineering...
The presence of V-pit defects affects the growth and properties GaN crystal. However, behavior in Na flux method have not been investigated...
Abstract The HSulf‐1 gene is an important factor that modulates the sulfation status of heparan sulfate proteoglycans (HSPGs) in extracellular matrix, resulting disturbance HSPG‐related signal transduction pathways. Recently, has been reported to be down‐regulated several human cancers. In this study, we first cloned and characterized 5′ promoter region (around 400 bp) contained high basal activity. We also found functional was hypermethylated a number cancer cell lines. Furthermore,...
As little is currently known about acid-sensing ion channels (ASICs) in intestinal epithelial cells, the aims of present study were to investigate expression and function ASICs particularly their physiological role acid-stimulated duodenal mucosal bicarbonate secretion (DMBS).RT-PCR digital Ca²(+) imaging used determine HT29 cells SCBN crypt cell lines. The DMBS was measured C57 black mice vivo this process.ASIC1a mRNA detected mucosa stripped from lines, which cytoplasmic free ([Ca²(+)...
Erythroid differentiation-associated gene (EDAG) has been considered to be a transcriptional regulator that controls hematopoietic cell differentiation, proliferation, and apoptosis. The role of EDAG in erythroid differentiation primary progenitor cells vivo remains unknown. In this study, we found is highly expressed CMPs MEPs upregulated during the CD34(+) following erythropoietin (EPO) treatment. Overexpression induced vitro using immunodeficient mice. Conversely, knockdown reduced...
Nrf2 is the key transcription factor regulating antioxidant response which crucial for cytoprotection against extracellular stresses. Numerous in vivo studies indicate that plays a protective role anti-inflammatory response. 3-(3-Pyridylmethylidene)-2-indolinone (PMID) synthesized derivative of 2-indolinone compounds. Our previous study suggested PMID induces activation Nrf2/ARE pathway, then protecting oxidative stress-mediated cell death. However, little known regarding properties severe...
Toll-like receptors (TLRs) have critical roles in innate immunity and inflammation the detailed mechanisms by which TLR signaling is fine tuned remain unclear. Keratin 8 (CK8) belongs to type II keratin family major compontent of intermediate filaments simple or single-layered epithelia. Here we report that down-regulation CK8 mice enhanced TLR-mediated responses, rendering more susceptible lipopolysaccharide (LPS)-induced endotoxin shock Escherichia coli-caused septic peritonitis with...
Hematopoiesis is a complex process regulated by sets of transcription factors in stage-specific and context-dependent manner. THAP11 factor involved cell growth, ES pluripotency, embryogenesis. Here we showed that was down-regulated during erythroid differentiation but up-regulated megakaryocytic cord blood CD34+ cells. Overexpression K562 cells inhibited the induced hemin with decreased numbers benzidine-positive mRNA levels α-globin (HBA) glycophorin A (GPA), knockdown enhanced...
During human erythroid maturation, Hsp70 translocates into the nucleus and protects GATA-1 from caspase-3 cleavage. Failure of to localize was found in Myelodysplastic syndrome (MDS) erythroblasts can induce dyserythropoiesis, with arrest maturation death erythroblasts. However, mechanism nuclear trafficking remains unknown. Here, we hematopoietic transcriptional regulator, EDAG, be a novel binding partner that forms protein complex during normal differentiation. EDAG overexpression blocked...
A crack-free AlN film with 4.5 μm thickness was grown on a 2-inch hole-type nano-patterned sapphire substrates (NPSSs) by hydride vapor phase epitaxy (HVPE). The coalescence, stress evolution, and dislocation annihilation mechanisms in the layer have been investigated. large voids located pattern region were caused undesirable parasitic crystallites sidewalls of nano-pattern early growth stage. coalescence c-plane hindered these three-fold special triangle void appeared. cross-sectional...
The MOOC-based education is an important means to improve the quality of as increasing development internet; meanwhile, assessment teaching indispensable aspect in management, and it has been more scale students' expansion, In order deal with challenges big data processing effectively field education, we designed a model on MOOC platform based comprehensive fuzzy evaluation. To verify effectiveness our method, control experiment was adopted explore significance evaluation results show that...