A5001817314- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cynara cardunculus studies
- Synthesis and Biological Evaluation
The Ohio State University
2022-2024
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly have significant limitations. The ergosterol biosynthetic pathway has been identified as a drug target in Leishmania. However, remarkable differences efficacy of antifungal azoles that inhibit biosynthesis reported for treatment leishmaniasis. To better understand sterol and elucidate mechanism underlying differential azoles, we developed new LC-MS/MS...
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing C14α-methyl group lanosterol, key step in ergosterol biosynthesis Leishmania. However, they exhibit varying degrees activities culture, suggesting existence unrecognized molecular targets. Our previous study reveals that, Leishmania, lanosterol undergoes parallel...