A5068630235- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Computational Drug Discovery Methods
- Synthesis and Biological Activity
- Metabolomics and Mass Spectrometry Studies
- Synthetic Organic Chemistry Methods
- Traditional Chinese Medicine Analysis
- Phytochemical compounds biological activities
- Carbohydrate Chemistry and Synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Sesquiterpenes and Asteraceae Studies
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Ginseng Biological Effects and Applications
- Chemical synthesis and alkaloids
- Molecular spectroscopy and chirality
Ocean University of China
2017-2019
Qingdao National Laboratory for Marine Science and Technology
2017-2019
A chemical investigation was conducted on the aerial parts of mangrove plant Sonneratia paracaseolaris, yielding five new triterpenoid paracaseolins A–E (1–4, and 11) together with twelve known analogues (5–10, 12–17). Their structures were established by extensive spectroscopic methods comparisons their data those related compounds. The cytotoxicities against P388, HeLa, A549, K562 tumor cell lines anti-H1N1 (Influenza virus) activities for isolates evaluated. Compound 4 showed potent...
Two pairs of new non‐brominated racematic pyrrole derivatives, (±)‐nakamurine D ( 1 ) and E 2 ), two diterpene alkaloids, isoagelasine C 16 isoagelasidine B 21 together with 13 known derivatives ((±)‐ 3 – 15 five alkaloids 17 20 , 22 were isolated from the South China Sea sponge Agelas nakamurai . The racemic mixtures, compounds 4 resolved into four enantiomers, (+)‐ (−)‐ by chiral HPLC structures absolute configurations elucidated on basis comprehensive spectroscopic analyses, quantum...
Three new sesquiterpenoids (sinuketal (
Chemical investigation of MeOH extract a South China Sea sponge Cacospongia sp. yielded 15 terpenoids belonging to three different skeleton-types, including the unusual C17γ-lactone norditerpenoids (1⁻3), rare C21 pyridine meroterpenoid (7), and notable C25 manoalide-type sesterterpenoids (4⁻6, 8⁻10). Compounds 1⁻5 were initially obtained as enantiomers, further separated be optically pure compounds (1a, 1b, 2a, 2b, 3a-r, 3b-r, 4a, 4b, 5a 5b) by chiral HPLC, with LiAlH₄ reduction aid for 3....
A new dolabellane diterpenoid, clavirolide H (1), together with eleven known compounds, including two diterpenoid (2 and 3), a rare cavernosine-type C17γ-lactone terpenoid (4), diketopiperazine (5) seven sterols (6-12), were isolated from the Xisha sponge Fascaplysinopsis reticulata. Their structures elucidated by extensive spectroscopic analysis, four types of compounds above isolates reported genus for first time. Selected 1, 4-6 9-12 evaluated cytotoxic activities against K562, HL-60,...
Chronic obstructive pulmonary disease (COPD) is a highly prevalent that has become the third leading cause of death worldwide. Cycloastragenol (CAG), which genuine sapogenin main active triterpene saponins in Astragali radix, bioavailable pre-clinical candidate for chronic (COPD), and it was investigated our previous study. In order to progress medical research, first efficiently produced on 2.5-kg scale via Smith degradation from astragaloside IV (AS-IV). Simultaneously, since impurity...