A5083424893- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Protein Hydrolysis and Bioactive Peptides
- Seaweed-derived Bioactive Compounds
- Biochemical effects in animals
- Chemical synthesis and alkaloids
- Moringa oleifera research and applications
- Synthesis and biological activity
- Educational Reforms and Innovations
- Synthesis and Biological Activity
- Medical Research and Treatments
- Synthesis of heterocyclic compounds
- Technology Assessment and Management
- University-Industry-Government Innovation Models
- Microbial Metabolites in Food Biotechnology
- Cancer-related Molecular Pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- Synthesis and Reactions of Organic Compounds
- Medicinal plant effects and applications
- Insect Utilization and Effects
- Educational Technology and Pedagogy
- Cancer-related cognitive impairment studies
- Lichen and fungal ecology
Zhejiang Ocean University
2015-2023
Zhejiang Marine Fisheries Research Institute
2019
Ocean University of China
2011-2018
To screen, prepare, identify, and evaluate the activities of natural antioxidants for treating chronic diseases caused by oxidative stress. Two algal proteins, namely ZD10 ZD60, precipitated with 10 60% (NH4)2SO4 were extracted from red algae Eucheuma cottonii (E. cottonii) hydrolyzed using five proteolytic enzymes. The results showed that ZD60 played most significant role in enhancement 2,2-diphenyl-1-picrylhydrazyl radical (DPPH⋅) scavenging activity (25.91 ± 0.24%) among all protein...
Eight novel and three known antioxidant peptides isolated from protein hydrolysate of Moringa oleifera seeds, using ultrafiltration, anion-exchange chromatography, gel filtration chromatography reversed phase high performance liquid (RP-HPLC). The were identified as Gly-Tyr (GY), Pro-Phe-Glu (PFE), Tyr-Thr-Arg (YTR), Phe-Gly (FG), Gln-Tyr (QY), Ile-Asn (IN), Ser-Phe (SF), Ser-Pro (SP), the Tyr-Phe-Glu (YFE), Ile-Tyr (IY) Leu-Tyr (LY), respectively, amino acid sequence analyzer electrospray...
Two new indole-diterpenoids (1 and 2) a isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic (11) kojic (12), were isolated from fermentation broth of marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures Compounds 1–12 elucidated by spectroscopic analyses, quantum ECD calculations chemical method. New Compound 1 exhibited antibacterial...
To study the nutritional composition of Indian Moringa oleifera seed and antioxidant activity M. polypeptide, was used as raw material for analysis content determination. After extraction protein, enzymatic hydrolysis with flavourzyme, dispase, papain, pepsin, alcalase conducted different time, optimal conditions determined DPPH scavenging capacity an indicator. The polypeptides obtained by were ultrafiltered, active peptide fragments tracked DPPH, HO (•OH), ABTS superoxide anion (O2•-) free...
Five new cerebrosides, chrysogesides A−E (1−5), and two 2-pyridone alkaloids, chrysogedones A B (6 7), were isolated from the fermentation broth of Penicillium chrysogenum PXP-55, a halotolerant fungus grown in hypersaline medium. Among them, B−D (2−4) are first cerebrosides that contain an unsaturated C19-fatty acid. Their structures identified by spectroscopic chemical methods, including CD spectroscopy as well modified Mosher's method. Compound 2 showed antimicrobial activity against...
To obtain structurally novel and bioactive natural compounds from marine-derived microorganisms, the effect of high salt stress on secondary metabolite production in fungal strain, Spicaria elegans KLA-03, was investigated. The organism, which isolated marine sediment, produced different metabolites when cultured 3% 10% saline conditions. Four characteristic metabolites, only salinity culture, were isolated, their structures identified as...
A chemical-epigenetic method was used to enhance the chemodiversity of a marine algicolous fungus. Apart from thirteen known compounds, (+)-brevianamide R ((+)-3), (‒)-brevianamide ((‒)-3), Q ((+)-4), ((‒)-4), brevianamide V ((+)-5), W ((‒)-5), K (6), diorcinol B (7), C (8), E (9), J (10), (11), 4-methoxycarbonyldiorcinol (12), two new (+)- and X ((+)- (‒)- 2)), as well naturally occurring one, 3-[6-(2-methylpropyl)-2-oxo-1H-pyrazin-3-yl]propanamide (1), were isolated cultures Aspergillus...
Two new pimarane diterpenes, libertellenone M (1) and N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D-1 derived high-latitude soil Arctic. The structures these determined by spectroscopic data as well experimental calculated electronic circular dichroism (ECD) analysis. Antimicrobial cytotoxic activities evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, Vibrio vulnificus, each MIC...
A water-soluble low molecular⁻weight polysaccharide named UP2-1 was isolated and purified from the marine green algae Ulothrixflacca using ion-exchange size-exclusion chromatography. Composition characteristics analyses showed that a sulfated glucuronorhamnan consisting of rhamnose glucuronic acid in ratio 2:1 with 21% sulfate content molecular weight 5.0 kDa. Structural properties were determined desulfation methylation combined infrared spectrum (IR), gas chromatography-mass spectrometer...
Marine fungi can metabolize structurally diverse active components, and have become an important source of drug lead molecules. In the present study, chemical investigation on EtOAc extract fermentation broth marine-derived fungus Trametes sp. ZYX-Z-16 led to isolation eight meroterpenoids (1-8), including two undescribed ones, together with ten ergostane steroid analogues (9-18). The structures new spiromeroterpenoids, asnovolin H (1) I (2), were determined based 1D, 2D NMR, HRESIMS...
To explore bioactive polysaccharides from the byproducts of squid processing, a heteropolysaccharide, named SV2-1, was isolated viscera Ommastrephes bartrami by autolysis, anion-exchange and gel-permeation chromatography measured for its neuroprotective activity. It homogeneous polysaccharide with molecular weight 2.3 kDa HPSEC analysis. SV2-1 contained glucuronic acid, galactosamine fucose in ratio 1.0:1.1:1.2. Its structural characteristics were elucidated methylation analysis, gas...
范 杰 a 孙坤来 a,c 朱伟明 * ,a ( 中国海洋大学医药学院 海洋药物教育部重点实验室 青岛 266003) b 贵州省中国科学院天然产物化学重点实验室 贵州 550002) c 浙江海洋大学食品与医药学院 舟山 316022) 摘要 研究深海沉积物来源的链霉菌 Streptomyces malaysiensis OUCMDZ-2167 的活性天然产物.采用硅胶和凝胶柱色 谱及高效液相色谱等手段, 从链霉菌 S. 的发酵产物中分离纯化了 1 个新的呋喃衍生物 以 及 10 个已知物 2～11; 采用质谱、紫外、红外、核磁共振和比旋光等方法将其结构分别鉴定为: 4-羟甲基呋喃-2-甲酸 甲酯(1)、呋喃-2,4-二甲酸二甲酯(2)、格尔德霉素(3)、17-O-去甲基格尔德霉素(4)、尼日利亚菌素(5)、尼日利亚菌素钠 (6)、30-O-乙酰基尼日利亚菌素(7)、奥布菌素(8)、洋橄榄叶素(9)、surugapyrone A (10)和杀菌素 (11). 采用细胞计数 试剂盒-8 (CCK-8)和噻唑蓝(MTT)法分别评价了化合物对 K562 和 MCF-7 A549...
Camellia oleifera is an important Chinese commercial crop. can display abnormal leaves due to infection by the parasitic fungus Exobasidium gracile. gracile was isolated from infected and used in fermentation, exopolysaccharides EP0-1 EP0.5-1 were purified fermentation broth. alkaline polysaccharide consisting mainly of linkages α-d-Manp(1→, →2)-α-d-Manp(1→ →6)-α-d-Manp(1→, →3)-α-d-Glcp(1→ and→4)-α-d-Glcp(1→, terminal β-d-Galf, (1→5)-β-d-Galf, β-D-GlcN(1→. acidic galactofuranose-containing...