A5100456922- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Corneal surgery and disorders
- Phytochemicals and Medicinal Plants
- Natural Antidiabetic Agents Studies
- Neurological Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Traditional Chinese Medicine Studies
- Biosensors and Analytical Detection
- Computational Drug Discovery Methods
- Chromatography in Natural Products
- Muscle activation and electromyography studies
- Global Maternal and Child Health
- Protein Interaction Studies and Fluorescence Analysis
- Maternal and Perinatal Health Interventions
- Antibiotics Pharmacokinetics and Efficacy
- Endometriosis Research and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Mass Spectrometry Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Corneal Surgery and Treatments
Hunan Normal University
2025
Guiyang Medical University
2025
Changsha Normal University
2025
Jiading District Central Hospital
2024
Chengdu Second People's Hospital
2024
Nanjing University of Science and Technology
2024
Sanya Central Hospital
2024
Ruijin Hospital
2024
Shanghai Jiao Tong University
2024
Peking University
2014-2023
As a natural flavonolignan, silibinin is reported to possess multiple biological activities, while the inhibitory potential of on carbohydrate-hydrolyzing enzymes still unclear. Therefore, in this study, effect and underlying mechanism against α-amylase/α-glucosidase were investigated. The results indicated that showed strong efficiency noncompetitive manners exhibited synergistic inhibition α-glucosidase with acarbose. However, interestingly, was significantly hindered various milk...
This study investigates the application of artificial fish swarm algorithm (AFSA) in power allocation for multiple-input and multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) relay underwater acoustic (UWA) communication systems. First, by using singular value decomposition technique, two-hop transmission links are converted into virtual direct an single-input single-output OFDM (SISO-OFDM) system. Then, a optimisation problem, together with assignment subcarriers nodes,...
ABSTRACT Deubiquitinating enzymes (DUBs) are integral regulators of protein stability. Among these, Ubiquitin‐specific protease 18 (USP18) has emerged as a potential therapeutic target for heart failure. However, its precise role in atherosclerosis remains to be comprehensively understood. This study endeavours examine the impact USP18 on and elucidate corresponding molecular mechanisms. Our studies indicate an elevated expression human coronary atherosclerotic plaques. Notably, knockdown...
High-risk human papillomavirus (HR-HPV) screening has increased colposcopy referrals, particularly for women with HR-HPV positivity but no intraepithelial lesion or malignancy (NILM) and those atypical squamous cells of undetermined significance (ASC-US). A fraction low-grade lesions (LSILs) is associated cervical neoplasia grade 2 worse (CIN2+) during diagnosis. This study evaluated the ability GYPC methylation (GYPCm ) to distinguish between <CIN2 CIN2 + in HPV-positive NILM, ASC-US, LSIL...
Two new pimarane diterpenes, libertellenone M (1) and N (2), together with five known compounds were isolated from the culture extract of Eutypella sp. D-1 derived high-latitude soil Arctic. The structures these determined by spectroscopic data as well experimental calculated electronic circular dichroism (ECD) analysis. Antimicrobial cytotoxic activities evaluated. Compound 3 exhibited weak antibacterial activity against Escherichia coli, Bacillus subtilis, Vibrio vulnificus, each MIC...
A method has been developed which allows direct measurement of partition coefficients (log D, log P) using liquid chromatography-mass spectrometry (LC-MS). The high throughput, microtiter plate based protocol uses small quantities 10 mM analyte in DMSO solution (5 microL) and is therefore amenable to standard archive screening formats. Single Ion Monitoring (SIM) mass used achieve optimal sensitivity. Experimental D values for 34 known drugs have determined, with ranging from -2 5, giving...
The chemical components of Huanglian Decoction were identified by ultra-performance liquid chromatography-quadrupole-time-of-flight-tandem mass spectrometry(UPLC-Q-TOF-MS/MS) technology. gradient elution was conducted in Agilent ZORBAX Extend-C_(18) column(2.1 mm×100 mm, 1.8 μm) with the mobile phase 0.1% formic acid aqueous solution(A)-acetonitrile(B) at a flow rate 0.3 mL·min~(-1) and column temperature 35 ℃. MS adopted positive negative ion mode electrospray ionization(ESI), data...
A simple and reliable method for distinguishing Danshen is important to evaluate the quality clinical efficiency of these species. An HPLC was developed determination protocatechuic aldehyde, salvianolic acid A, B, cryptotanshinone, tanshinone I IIA in 23 samples Salvia. The analytes were separated on an Agilent XDB C18 reversed-phase column coupled with a Phenomenex guard using gradient elution acetonitile–0.1% aqueous phosphoric as mobile phase at flow rate 0.8 mL/min UV detection 280 nm....
Transradial approach is the classical access for coronary angiography and percutaneous intervention (PCI). With increase in number of interventional procedures, some disadvantages transradial have also been found, it easy to lead various complications, such as radial artery occlusion, nerve injury, puncture difficulties after spasm. Therefore, experts put forward distal therapy, which has advantages convenient positioning, postoperative hemostasis, less damage proximal improving patients'...
Monitoring the concentration of antibiotics rapidly and cost-effectively is crucial for accurate clinical medication timely identification drug-induced illnesses. Here, we constructed a novel fluorescent assay kit to monitor Zavicefta, an effective antibiotic composed avibactam (AVI) ceftazidime (CFZ) treat carbapenem-resistant gram-negative bacteria infections. AVI can emit fluorescence, but CFZ cannot. To enable simultaneous measurement both in one kit, designed molecularly imprinted...
Introduction Venous thromboembolism (VTE) risk assessment at admission is of great importance for early screening and timely prophylaxis management during hospitalization. The purpose this study to develop validate novel models based on machine learning (ML) methods. Methods In retrospective study, a total 3078 individuals were included with their Caprini variables within 24 hours admission. Then several ML built, including logistic regression (LR), random forest (RF), extreme gradient...
In a response to growing demand for environments of 70dB or less noise levels, many industrial sectors have focused with some form control system. Active (ANC) has proven be the most effective technology. This paper mainly investigates application neural network on self-adaptation system in active (ANC). An silencing is made which adopts motional feedback loudspeaker as not controlling source but detecting sensor. The working fundamentals and characteristics are analyzed detail. By analyzing...