A5053508248- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Lipid metabolism and biosynthesis
- Click Chemistry and Applications
- Photodynamic Therapy Research Studies
- DNA and Nucleic Acid Chemistry
- Supramolecular Chemistry and Complexes
- Superconducting Materials and Applications
- Molecular spectroscopy and chirality
- Mercury impact and mitigation studies
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Shape Memory Alloy Transformations
- Magnetic confinement fusion research
- Protein Structure and Dynamics
- Microwave-Assisted Synthesis and Applications
- Redox biology and oxidative stress
- Nanocluster Synthesis and Applications
- Nonlinear Optical Materials Research
Second Xiangya Hospital of Central South University
2025
Central South University
2025
State Key Laboratory of Chemobiosensing and Chemometrics
2016-2024
Hengyang Normal University
2023-2024
Hunan University
2011-2024
Yunnan University
2024
PetroChina Southwest Oil and Gas Field Company (China)
2024
China-Japan Friendship Hospital
2024
Henan Agricultural University
2022
Changsha University
2017-2020
Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors with intrinsic hypoxia. However, type photosensitizers (PSs), especially ones near infrared (NIR) absorption, are limited and their efficacy needs improvement via new targeting tactics. We develop NIR PS by engineering acridinium derived donor-π-acceptor systems. The exhibits an exclusive PDT mechanism due to effective intersystem crossing disfavored energy transfer O2 , shows selective binding...
Subcellular viscosity is essential for cell functions and may indicate its physiological status. We screen two fluorescent probes by engineering tetraphenylethene (TPE) measuring in mitochondria lysosomes, respectively. These are only weakly emissive nonviscous medium the emission signals greatly enhanced viscous due to restriction of intramolecular motion. The presence pyridium has endowed one probe with mitochondrial specificity, while indole ring granted other lysosome-targeting ability....
Until now, it is a great challenge for the controllable synthesis of copper antimony sulfide (CAS) nanocrystals (NCs), as reactivity precursors quite difficult to be controlled during process. In present work, novel solution-based method proposed synthesize CAS NCs by choosing N,N′-diphenylthiourea precursor, which favorable balancing relative Cu and Sb ions. It found that three phases (CuSbS2, Cu12Sb4S13 Cu3SbS4) with size tunability were successfully synthesized first time. To best our...
Abstract Nanostructured materials have demonstrated superior radiation-damage tolerance compared to their coarse-grained counterparts, contributing the extended lifespan of nuclear materials. However, mechanisms underlying this enhanced irradiation resistance remain unclear. In study, we present atomistic simulations investigate impact Cu/W heterophase interface on evolution irradiation-induced defects. The simulation results reveal that interfaces can act as defect sinks, effectively...
The significant role of microRNAs (miRNAs) in the regulation pathological ocular neovascularization makes them both biomarkers and therapeutic targets vascular eye diseases. However, their acute sensitive detection continue to be a challenge. An integrative DNA probe (detection probe) was developed enable single-step miRNAs with high sensitivity specificity. This combines functions specific target recognition, DNAzyme unit-based signal reaction, polymerase/endonuclease-assisted cycle. In...
Histone deacetylases (HDACs) play essential roles in transcription regulation and are valuable theranostic targets. However, there no activatable fluorescent probes for imaging of HDAC activity live cells. Here, we develop the first time a novel two-photon fluorescence probe that enables situ living cells tissues. The is designed by conjugating an acetyl-lysine mimic substrate to masked aldehyde-containing fluorophore via cyanoester linker. Upon deacetylation HDAC, undergoes rapid...
We have developed a novel fluorescent probe of benzoindocyanine (BICP), which is able to target mitochondria and realize sensitive selective detection NTR.
Abnormal lipid metabolism, renal accumulation and lipotoxicity are associated with the pathological features of glomerulopathy. However, mechanisms by which leads to development or progression this disease have not been fully elucidated. In work, we identified a role for rate-limiting enzyme in lipolysis, adipose triglyceride lipase (ATGL; also called patatin-like phospholipase domain-containing protein 2), metabolism kidney disease. ATGL-deficient (Atgl(-/-)) mice displayed albuminuria,...
We have developed a novel TPE fluorescent probe (Q<sub>3</sub>CA-P), with long Stokes shift and high signal-to-background ratio, for hNQO1 detection imaging.
Mitochondrial vicinal dithiol-containing proteins (VDPs) are key regulators in cellular redox homeostasis and useful markers for diagnostics of redox-dependent diseases. Current probes fail to target mitochondrial VDPs show limited sensitivity response rate. We develop a novel fluorescent probe using an engineered benzoxadiazole fluorophore that allows selective targeting mitochondria exhibits highly sensitive environment responsiveness. This is almost nonfluorescent aqueous media, while...
Formaldehyde (FA), as a reactive carbonyl species and signaling molecule, plays an important role in living systems. Here, FA-responsive probe with fast response great selectivity is designed based on aggregation-induced emission. The prepared by functionalizing tetraphenylethene (TPE) two amine groups. FA detected the solubility differences between amine-functionalized TPE corresponding Schiff bases after reaction FA. exhibits limit of detection 40 nM time ∼90 s. Furthermore, its ability to...
Many motile eukaryotic cells determine their direction by measuring external chemical gradients through the binding of ligands to membrane bound receptors. This process is limited fluctuations arising from and diffusion ligand molecules. Here, we apply estimation-theoretic methods physical limits gradient sensing for that are noncircular have an internal bias. Specifically, derive theoretical expressions accuracy in elliptical cells. highly can significantly deviate derived circular...
An intramolecular charge transfer and excited state proton based fluorescent probe was developed for highly selective detection of FA.
A schematic illustration of rotors to detect mitochondrial and lysosomal viscosity during mitophagy.
Abstract Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors with intrinsic hypoxia. However, type photosensitizers (PSs), especially ones near infrared (NIR) absorption, are limited and their efficacy needs improvement via new targeting tactics. We develop NIR PS by engineering acridinium derived donor‐π‐acceptor systems. The exhibits an exclusive PDT mechanism due to effective intersystem crossing disfavored energy transfer O 2 , shows selective binding...
Glyphosate is a widely used broad-spectrum herbicide in agriculture and horticulture to control variety of weeds undesirable plants. However, the excessive use glyphosate has raised number environmental human health concerns. It urgent develop tools detect glyphosate. Herein, novel dual-signal probe CCU-Cu2+ was designed synthesized on basis CCU. CCU exhibited excellent selectivity great sensitivity for Cu2+ which were based both fluorescence "turn-off" reaction comparative color...