A5101548654- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Chinese history and philosophy
- Cancer-related molecular mechanisms research
- China's Socioeconomic Reforms and Governance
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Birth, Development, and Health
- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- NF-κB Signaling Pathways
- Cardiovascular Disease and Adiposity
- Cardiac Imaging and Diagnostics
- CRISPR and Genetic Engineering
- Arctic and Russian Policy Studies
- Protease and Inhibitor Mechanisms
- Chemokine receptors and signaling
- Infrastructure Resilience and Vulnerability Analysis
- Acute Myocardial Infarction Research
- Circular RNAs in diseases
- Gastrointestinal Tumor Research and Treatment
Shanghai Pulmonary Hospital
2023-2025
Tongji University
2023-2025
Army Medical University
2017-2024
Daping Hospital
2017-2024
Jinan University
2023
Guangdong Medical College
2022
Fudan University
2003-2019
Hainan Tropical Ocean University
2001-2004
Afatinib, an irreversible ErbB-family blocker, could improve the survival of advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer patients (NSCLCm+). This phase II trial (NCT04201756) aimed to assess feasibility neoadjuvant Afatinib treatment for stage III NSCLCm+. Forty-seven received (40 mg daily). The primary endpoint was objective response rate (ORR). Secondary endpoints included pathological complete (pCR) rate, downstaging margin-free resection (R0)...
<title>Abstract</title> Background This study aimed to evaluate the efficacy and safety of camrelizumab, an anti-PD-1 antibody, combined with either chemotherapy or apatinib, a VEGFR-2 inhibitor, as neoadjuvant treatment for stage IIA-IIIA NSCLC. Methods prospective, multicenter, dual-arm, non-randomized phase II trial enrolled participants from four hospitals in China between September 2020 March 2022. Patients received 2–4 cycles followed by surgery. Arm-AR (n = 28) included patients...
Abstract Ovarian cancer is known as one of the most common malignancies gynecological system, whose treatment still not satisfactory because unclear understanding molecular mechanism. PSMC2 an essential component 19 S regulatory granules in 26 proteasome and its relationship with ovarian clear. In this study, we found that was upregulated tissues, associated tumor grade could probably predict poor prognosis. Knocking down endogenous expression cells decrease colony formation ability, cell...
Dendritic cells (DCs) are the most potent antigen‑presenting cells, and indispensable in immune system. Prostaglandin E2 (PGE2) has been demonstrated to modulate migration of DCs, but with inconsistent results. The present study, based on our previous research, used murine bone marrow‑derived DCs elucidate potential regulatory mechanism PGE2 DCs. results indicated that served a dual role regulating dose‑dependent manner. High concentrations inhibited cell migration, whereas low exhibited...
Abstract Cervical cancer is the fourth most common malignant tumors in female worldwide. Cirular RNAs (circRNA) represent a new class of regulatory RNA and play pivotal role carcinogenesis development tumors. However, their functions have not been fully elucidated cervical cancer. In this study, we identified an upregulated circRNA, circ_0001589, both fresh clinical samples tissue microarray Transwell assay cell apoptosis by flow cytometry demonstrated circ_0001589 promotes...
To evaluate the clinical correlation of epithelial-mesenchymal transition (EMT) with PRL-3 and MMP9 expression in circulating tumor cells (CTCs) patients colorectal cancer (CRC).Between January 2016 December 2018, EMT phenotype-based subsets CTCs levels were identified, their values 172 evaluated. The isolated, classified, counted using CanPatrol™ CTC filtration system. (epithelial cells, mesenchymal biphenotypic cells), as well expression, detected by RNA situ hybridization.CTCs 93.0%...
Abstract Endometrial cancer (EC) is one of the most common cancers among women, while incidence EC rising. Many studies have found that Kinesin family member 15 (KIF15) highly expressed in a series cancers, but role KIF15 unclear. We detected expression level microarray tissues by immunohistochemical staining (IHC), and analyzed correlation between pathological characteristics patients. After inhibit cells with lentivirus, cell proliferation apoptosis were respectively CCK8 assay, flow...
Serous ovarian cancer (SOC) is a main histological subtype of cancer, in which stem cells (CSC) are responsible for its chemoresistance. However, the underlying modulation mechanisms chemoresistance led by stemness still undefined. We aimed to investigate potential drug-response indicators among stemness-associated biomarkers advanced SOC samples. The mRNA expression-based index (mRNAsi) Cancer Genome Atlas (TCGA) was evaluated and corrected tumor purity. Weighted gene co-expression network...
Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases risk of cancer recurrence and distant metastasis. The properties lymph node (LNM-CRC) cells are poorly understood, effective therapies still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha (FAP
Abstract Preeclampsia (PE) is a gestational disease, which seriously impairs maternal and infant health. However, the pathogenesis of PE remains unclear. The aromatase (CYP19A1) in placenta converts androgens from fetal adrenal glands to estrogen. Therefore, this change expression or function subsequent steroids could be related pathophysiology PE. In study, we first analyzed CYP19A1 clinical placental tissues as well level sex hormones corresponding serum samples. results showed that...
Continuous human papillomavirus (HPV) infection is a critical cause of cervical lesions; however, the specific mechanism currently not clear. E6 one most important oncoproteins associated with HPV, which regulates synthases in production prostaglandin E2 (PGE2). Notably, PGE2 has been reported to be upregulated lesions. An insufficient number mature dendritic cells (DCs), unable an effective immune response, Therefore, this study explored possible causes HPV16‑positive lesions by identifying...
Background The incidence of coronary heart disease (CHD) is higher in Northern than that Southern China, however differences traditional CHD risk factors do not fully explain this. No study has examined the subclinical atherosclerosis may help incidence. This these using computed tomography (CT) for calcification between and China. Methods We selected a random sample participants large multi-center ongoing epidemiologic calcium scanning one northern city (North) (Beijing, n = 49) two...
Determination of the genomic copy number Cre transgene is critical for establishment transgenic animal models. We demonstrate a real-time quantitative polymerase chain reaction (RT-qPCR) based method determination improved (iCre), which was tested in mouse model CYP19A1-iCre. The standards were derived from tandem repeats iCre fragments constructed by new application megaprimer PCR. Two rounds PCR used to obtain specific fragments, subsequently cloned into pUCm-T vectors. After IL-2...
BACKGROUND: Preeclampsia is a pregnancy-specific disorder with unclear pathogenesis. Irisin, recently identified exercise-induced factor, significantly influences lipid metabolism and cardiovascular function. Nonetheless, its role in trophoblast development during human placentation the related intracellular signaling pathways remain poorly understood. METHODS: We assessed peripheral blood irisin expression early pregnancy among patients preeclampsia correlation key clinical indicators. In...