A5100361131- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- Gestational Diabetes Research and Management
- Ion Channels and Receptors
- Congenital Diaphragmatic Hernia Studies
- Thermoregulation and physiological responses
- Parathyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Fibroblast Growth Factor Research
- Fetal and Pediatric Neurological Disorders
- Wound Healing and Treatments
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Biochemical effects in animals
- Estrogen and related hormone effects
- Diabetic Foot Ulcer Assessment and Management
- Pleural and Pulmonary Diseases
- Posttraumatic Stress Disorder Research
- Dental Erosion and Treatment
- Cancer Cells and Metastasis
Army Medical University
2014-2024
Army Medical College
2022-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Ganzhou People's Hospital
2024
Nanchang University
2024
Daping Hospital
2013-2023
University of Colorado Denver
2022
Capital Medical University
2019-2022
Guangxi Medical University
2022
Preeclampsia (PE) is an obstetric disorder with high morbidity and mortality rates but without clear pathogeny. The dysfunction of the blood coagulation-fibrinolysis system a salient characteristic PE that varies in severity, necessitates different treatments. Therefore, it necessary to find suitable predictors for onset severity PE.We aimed evaluate coagulation parameters platelet indices as potential PE.Blood samples from 3 groups subjects, normal pregnant women (n = 79), mild preeclampsia...
The prevalence of obesity has dramatically increased worldwide and attracted rising attention, but the mechanism is still unclear. Previous studies revealed that transient receptor potential vanilloid 1 (TRPV1) channels take part in weight loss by enhancing intracellular Ca2+ levels. However, effect dietary capsaicin on not completely understood. transfer induced connexin43 (Cx43) molecules between coupled cells takes adipocyte differentiation. Whether TRPV1-evoked alterations Cx43-mediated...
High-salt diet-induced cardiac hypertrophy and fibrosis are associated with increased reactive oxygen species production. Transient receptor potential vanilloid type 1 (TRPV1), a specific for capsaicin, exerts protective role in remodeling that resulted from myocardial infarction, peroxisome proliferation-activated receptors δ (PPAR- ) play an important metabolic myocardium remodeling. However, it remains unknown whether activation of TRPV1 could alleviate the effect cross-talk between PPAR-...
This study investigated the roles of Rho protein in epidermal growth factor (EGF)-induced trophoblast cell migration and its mechanism. Using choriocarcinoma lines JEG-3 JAR first-trimester human chorionic villus explant cultures on matrigel, we examined EGF-mediated stimulation migration. EGF is shown to have a dose-dependent effect A low concentration (1 ng/ml) has stimulatory migration, whereas high concentrations (100 shows an inhibitory effect. activates RhoA RhoC, but not RhoB, through...
Aims: Previous studies have revealed that the increased shedding of syncytiotrophoblast extracellular vesicles (STBM) may lead to preeclampsia (PE). We aimed identify proteins carried by STBM and their potential pathological roles in early-onset severe PE. Methods: In this study, we performed a differential proteomic analysis from PE patients, using iTRAQ isobaric tags 2D nano LC-MS/MS. were generated vitro explant culture method, then verified electron microscopy western blot analysis....
Abstract Background The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive diagnosis. We have now assessed the possibility detecting single‐nucleotide differences between and by polymerase chain reaction (PCR)/ligase detection reaction((LDR)/capillary electrophoresis. Methods PCR/LDR/capillary electrophoresis was applied to detect genotype c.454–397T>gene (ESR1) from experimental models at different sensitivity levels 13 samples.αC estrogen receptor....
Preeclampsia (PE) is a pregnancy-induced disorder characterized by the overproliferation of trophoblasts. Hydatidiform moles, which are associated with high risk developing PE, excessive proliferation trophoblastic tissue. H19 highly expressed in placental tissue; however, its biological function remains unclear. A fundamental modification gene DNA methylation, typically occurs CG-rich regions at promoter or first exon region. In this study, order to investigate methylation pattern 1 region...
Background . Metformin has been reported to decrease insulin resistance and is associated with a lower risk of pregnancy-induced hypertension preeclampsia. It widely accepted that the placenta plays crucial role in development Our aim explore effect metformin on Study Design We examined control diet-fed (isocaloric diet) pregnant mice (CTRL group), fed high-fat diet (HF high-fat-diet-fed treated (HF-M group). The HF were six weeks before pregnancy establish preeclampsia-like model; then,...
Background The pandemic of obesity is a global public health concern. Most studies on are skewed toward high-income and urban settings few covers low-income populations. This study focused the prevalence overweight their correlations with blood lipids/metabolites/enzymes (bio-indicators) in rural community typical remote western China. Methods was performed Muslim ethnic Uyghur Kashi Prefecture Xinjiang, about 4,407 km (2,739 miles) away from Beijing. Body mass index (BMI) major...
In recent years, the emergence of immunomodulatory drugs (IMiDs) has significantly improved clinical outcomes in patients with multiple myeloma (MM); however, serious adverse events (AEs) have hindered their safe application. This study aimed to characterize safety profiles and differences IMiDs through a disproportionality analysis using U.S. Food Drug Administration Adverse Event Reporting System (FAERS), post-marketing surveillance database.
Regulation of cellular response pattern to phosphorus ion (PI) is a new target for the design tissue-engineered materials. Changing high PI can maintain monocyte/macrophage survival in TEBV and signal increasing be converted by klotho adenosine signals through regulation energy metabolism monocytes/macrophages. As service our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may re-organized online delivery, but not copy-edited...
Abstract Preeclampsia (PE) is a gestational disease, which seriously impairs maternal and infant health. However, the pathogenesis of PE remains unclear. The aromatase (CYP19A1) in placenta converts androgens from fetal adrenal glands to estrogen. Therefore, this change expression or function subsequent steroids could be related pathophysiology PE. In study, we first analyzed CYP19A1 clinical placental tissues as well level sex hormones corresponding serum samples. results showed that...