A5060916477- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Cancer-related molecular mechanisms research
- Peripheral Artery Disease Management
- RNA Research and Splicing
- Underwater Acoustics Research
- Parathyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Bacterial Identification and Susceptibility Testing
- Radar Systems and Signal Processing
- Cardiac Imaging and Diagnostics
- Pancreatic function and diabetes
- Thermoregulation and physiological responses
- Diet, Metabolism, and Disease
- Nanoplatforms for cancer theranostics
- Sepsis Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Lipid Membrane Structure and Behavior
- Aortic Disease and Treatment Approaches
- Underwater Vehicles and Communication Systems
- Congenital Heart Disease Studies
- RNA regulation and disease
- Nosocomial Infections in ICU
- Chromatography in Natural Products
Nanjing Drum Tower Hospital
2016-2025
Daping Hospital
2020-2024
Army Medical University
2019-2024
Nanjing Medical University
2024
State Council of the People's Republic of China
2021
Shanghai University
2019
General Department of Preventive Medicine
2019
Chongqing Medical University
2018
The Affiliated Yongchuan Hospital of Chongqing Medical University
2018
Children's Hospital of Zhejiang University
2018
High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high associated with nonalcoholic fatty liver disease, which an independent diseases, it remains elusive whether salt-induced hepatic damage leads to development of diseases.Mice were fed normal or high-salt diet 8 weeks determine effect loading on histological changes and blood pressure, withdrawal metformin treatment also conducted some diet-fed mice. Adeno-associated...
Abstract Background Altered adipokine secretion in dysfunctional adipose tissue facilitates the development of atherosclerotic diseases including lower extremity peripheral artery disease (PAD). Asprosin is a recently identified and displays potent regulatory role metabolism, but relationship between asprosin PAD remains uninvestigated. Methods 33 type 2 diabetes mellitus (T2DM) patients (DM), 51 T2DM with (DM + PAD) 30 healthy normal control (NC) volunteers were recruited blood samples...
Abstract Objective Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was explore whether sirtuin 3 (SIRT3), mitochondrial deacetylase, participates this pathophysiological process. Methods Macrophage‐specific Sirt3 knockout (Sirt3‐MKO) mice and wild‐type littermates were treated with high‐fat diet. Body weight, glucose tolerance, evaluated. Bone marrow–derived...
Abstract Controlled radical polymerization of N ‐vinylcaprolactam (NVCL) via reversible addition‐fragmentation chain transfer (RAFT) or macromolecular design the interchange xanthate (MADIX) was described, employing 2‐diphenylthiocarbamoylsulfanyl‐2‐methyl‐propionic acid (CTA1), (( O ‐ethylxanthyl)methyl)benzene (CTA2) and (1‐( ‐ethylxanthyl)ethyl)benzene (CTA3) as agents (CTA). It found that all CTAs led to controlled NVCL, with molecular weight increased along conversion monomer a...
Tissue bacterial infections are a major pathological factor in many diseases. Effects on this aspect focus for the development of coordinated therapeutic strategies killing and anti-inflammation. Here, inspired by biodetoxification capacity immune cells, multifunctional biomimetic nanovesicles (MϕM-LPs) that co-assembled macrophage membranes artificial lipids to deliver antibiotics treating infections, presented. The membrane endows MϕM-LPs with lipopolysaccharide inflammatory cytokine...
Background: This study addresses the critical need for timely and accurate diagnosis of early postoperative infection (EPI) following cardiac surgery. EPI significantly impacts patient outcomes healthcare costs, making its detection vital. Objectives: To develop, validate, clinically implement a machine-learning-based model diagnosing post-cardiac surgery, enhancing care. Methods: In this multi-center cohort spanning 2020 to 2022, data from four medical centers involved 2001 participants. Of...
To detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn first phase of insulin secretion.A total 56 patients newly diagnosed type 2 diabetes mellitus, 36 impaired tolerance (IGT) 45 normal were enrolled. Intravenous tests carried out to evaluate pancreatic β-cell function. The adipsin, interleukin-1β high-sensitivity C-reactive protein assayed.Serum significantly lower mellitus IGT than those group (P < 0.05). acute...
Excess salt intake is not only an independent risk factor for heart failure, but also one of the most important dietary factors associated with cardiovascular disease worldwide. Metabolic reprogramming in cardiomyocytes early event provoking cardiac hypertrophy that leads to subsequent events upon high loading. Although SGLT2 inhibitors, such as canagliflozin, displayed impressive health benefits, whether inhibitors protect against hypertrophy-related metabolic loading remain elusive. To...
Abstract The combination of obesity and hypertension is associated with high morbidity mortality; however, the mechanism underlying obesity-induced remains unclear. In this study, we detected possible effects TRPV1, a previously identified antihypertensive calcium (Ca 2+ ) channel in adipose tissue, on occurrence mice lacking UCP1, spontaneously genetically manipulated model, by generating TRPV1 UCP1 double knockout mice. these mice, appeared earlier were more severe than or alone. further...
RNA-sequencing (RNA-seq) enables global identification of RNA-editing sites in biological systems and disease. A salient step many studies is to identify editing that statistically associate with treatment (e.g. case versus control) or covary factors, such as age. However, RNA-seq has technical features incumbent tests t-test linear regression) do not consider, which can lead false positives negatives.In this study, we demonstrate the limitations currently used introduce method, (REDITs), a...
Abstract Introduction Major depressive disorder (MDD) is one of the most common mental disorders worldwide. The aim this study was to identify potential pathological genes in MDD. Methods We searched and downloaded gene expression data from Gene Expression Omnibus database differentially expressed (DEGs) Then, Kyoto Encyclopedia Genes Genomes pathway, Ontology analysis, protein‐protein interaction (PPI) network were applied investigate biological function identified DEGs. quantitative...
A novel HA@ceria nanoquantum dots (HA@CQDs) exhibit efficient protective effects against damage induced by ROS. More importantly, aided H<sub>2</sub>O<sub>2</sub>, the HA@CQDs-Ce6/H<sub>2</sub>O<sub>2</sub> significantly enhanced PDT efficacy for tumor therapy.
Diabetic nephropathy (DN) is a progressive disease, the main pathogeny of which podocyte injury inducing glomerular filtration barrier and proteinuria.The occurrence development DN could be partly attributed to reactive oxygen species (ROS) generated by mitochondria.However, research on how mitochondrial dysfunction (MtD) ultimately causes DNA damage poor.Here, we investigated influence Klotho deficiency high glucose (HG)-induced in vivo vitro.First, found that absence aggravated diabetic...
Recently, the research on modulation identification of underwater acoustic (UWA) communication signals has attracted much attention. It is a challenge to identify in environment low signal-to-noise ratio (SNR), multipath interference, frequency and phase drift. In this paper, joint feature extraction algorithm proposed which combines method cyclic spectrum with high-order cumulant perform recognition UWA communication. algorithm, higher-order features their counterparts after square...
Hypercortisolism is characterized by metabolic disorders and high mortality rates. Adrenalectomy medical therapies are considered major treatment options. However, some patients, especially young strongly against undergoing surgery in case of secondary hypocortisolism or relapses that require replacement supplements pharmacological interventions. In such cases, alternative needed to treat hypercortisolism.We report a 27-year-old Chinese female with adrenal cortisol-producing adenoma. The...
With the advancement of individual medicine, additive manufacturing NiTi alloys, which are used as biomedical implantation materials, is becoming increasingly popular. However, insufficient corrosion resistance these alloys still requires improvement. In this study, we fabricated various with and without TiC addition using selective laser melting (SLM). The effects content on microstructure, phase transition, SLM-fabricated were thoroughly investigated. results indicated that promoted grain...
CNG channels are cyclic nucleotide-gated Ca 2+ -permeable that suggested to be involved in the activity-dependent alterations of synaptic strength thought underlie information storage CNS. In this study, we isolated an endogenous RNA transcript antisense CNGα1 mRNA. This was capable down-regulating expression sense theXenopus oocyte system. RT-PCR, Northern blot, and situ hybridization analyses showed coexpressed with mRNA many regions human brain, notably those were long-term potentiation...
Early postoperative bacterial pneumonia and sepsis (ePOPS), which occurs within the first 48 hours after cardiovascular surgery, is a serious life-threatening complication. Diagnosis of ePOPS extremely challenging, existing diagnostic tools are insufficient. The purpose this study was to construct novel prediction model for ePOPS.Least Absolute Shrinkage Selection Operator (LASSO) with logistic regression used diagnose based on patients' comorbidities, medical history, laboratory findings....
Recently, the research of underwater acoustic(UWA) communication has been paid more and attention. Because influence acoustic channel, UWA signals we received usually have character multipath, delay low signal-to-noise ratio(SNR), which make it difficult to estimate signal carrier frequency. The cyclic spectrum method good parameter estimation effect for SNR signal. By calculating spectral correlation function signal, cross section is obtained peak value traversed frequency In this paper,...
In recent years, with the exploitation of marine resources and rapid development environmental research, underwater acoustic communication technology has been a hot topic in field. Underwater signal recognition parameter estimation therefore have become increasingly attractive. Direct spread spectrum sequence signal(DSSS) is also widely used field communication. However, complexity seawater environment reason for multipath interference low signal-to-noise ratio(SNR), which lead to great...