A5079191718- Sodium Intake and Health
- Ion Channels and Receptors
- Biochemical Analysis and Sensing Techniques
- Process Optimization and Integration
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Cardiac electrophysiology and arrhythmias
- Olfactory and Sensory Function Studies
- Bariatric Surgery and Outcomes
- Nutrition, Health and Food Behavior
- Catalysis and Hydrodesulfurization Studies
- Ion Transport and Channel Regulation
- Metabolism, Diabetes, and Cancer
- Coal and Coke Industries Research
- Advanced Control Systems Optimization
- Magnesium in Health and Disease
- Catalysts for Methane Reforming
- Diet, Metabolism, and Disease
- Carbon Dioxide Capture Technologies
- Circadian rhythm and melatonin
- Hormonal Regulation and Hypertension
- Structural Integrity and Reliability Analysis
- Advanced Glycation End Products research
Army Medical University
2013-2024
Daping Hospital
2013-2024
Tianjin University
2022-2024
Shanghai Shipbuilding Technology Research Institute
2022
Suzhou Institute of Biomedical Engineering and Technology
2017
Chinese Academy of Sciences
2017
University of North Carolina at Chapel Hill
2014
Deleted Institution
2010
Background/Aims: Age-related cerebrovascular dysfunction contributes to stroke, cerebral amyloid angiopathy, cognitive decline and neurodegenerative diseases. One pathogenic mechanism underlying this effect is increased oxidative stress. Up-regulation of mitochondrial uncoupling protein 2 (UCP2) plays a crucial role in regulating reactive oxygen species (ROS) production. Dietary patterns are widely recognized as contributors cardiovascular disease. In study, we tested the hypothesis that...
High salt intake is the leading dietary risk factor for cardiovascular diseases. Although clinical evidence suggests that high associated with nonalcoholic fatty liver disease, which an independent diseases, it remains elusive whether salt-induced hepatic damage leads to development of diseases.Mice were fed normal or high-salt diet 8 weeks determine effect loading on histological changes and blood pressure, withdrawal metformin treatment also conducted some diet-fed mice. Adeno-associated...
High salt intake is a major risk factor for hypertension and associated with cardiovascular events. Most countries exhibit traditionally high intake; thus, identification of an optimal strategy reduction at the population level may have impact on public health. In this multicenter, random-order, double-blind observational interventional study, subjects spice preference had lower blood pressure than who disliked spicy food. The enjoyment flavor enhanced sensitivity reduced preference. Salt...
High-salt diet induces cardiac remodelling and leads to heart failure, which is closely related mitochondrial dysfunction. Transient receptor potential (TRP) channels are implicated in the pathogenesis of We investigated whether activation TRP vanilloid (subtype 1) (TRPV1) by dietary capsaicin can, ameliorating dysfunction, prevent high-salt diet-induced hypertrophy.Male wild-type (WT) TRPV1(-/-) mice were fed a normal or with without for 6 months. Their parameters endurance capacity...
High salt (HS) intake contributes to the development of hypertension. Epithelial sodium channels play crucial roles in regulating renal reabsorption and blood pressure. The transient receptor potential vanilloid 1 (TRPV1) cation channel can be activated by its agonist capsaicin. However, it is unknown whether dietary factors act on urinary excretion epithelial (ENaC) function. Here, we report that TRPV1 activation capsaicin increased through reducing wild-type (WT) mice a HS diet but not...
Hypertension-induced renal fibrosis contributes to the progression of chronic kidney disease, and apigenin, an anti-hypertensive flavone that is abundant in celery, acts as agonist transient receptor potential vanilloid 4 (TRPV4). However, whether apigenin reduces hypertension-induced fibrosis, well underlying mechanism, remains elusive. In present study, deoxycorticosterone acetate (DOCA)-salt hypertension model was established male Sprague-Dawley rats were treated with or vehicle for...
Mitochondrial Ca
Background Environmental cold‐induced hypertension is common, but how to treat remains an obstacle. Transient receptor potential melastatin subtype 8 (TRPM8) a mild cold‐sensing nonselective cation channel that activated by menthol. Little known about the effect of TRPM8 activation menthol on mitochondrial Ca 2+ homeostasis and vascular function in hypertension. Methods Results Primary smooth muscle cells from wild‐type or Trpm8 −/− mice were cultured. In vitro, we confirmed sarcoplasmic...
High salt intake is one independent risk factor for cardiac hypertrophy. Polycystic kidney disease 2-like 1 (PKD2L1, also called TRPP3) acts as a sour sensor in taste cells, and its possible role the cardiovascular system unknown. Here, we report that knockout of PKD2L1 exacerbated high-salt diet (HSD)-induced hypertrophy fibrosis, accompanied by dysfunction reduced mitochondrial oxidative phosphorylation enzyme activity. Furthermore, knockdown led to more serious Ca2+ overload uptake...
Background Salt-sensitive hypertension is highly prevalent and associated with cardiorenal damage. Large clinical trials have demonstrated that SGLT2 (sodium-glucose cotransporter 2) inhibitors exert hypotensive effect protective benefits in patients without diabetes. However, the underlying mechanism remains elusive. Methods Results Dahl salt-sensitive rats salt-insensitive controls were fed 8% high-salt diet some of them treated canagliflozin. The blood pressure, urinary sodium excretion,...
Background We investigated the hypothesis that favorable effects of gastrointestinal ( GI ) intervention on hypertension HTN and cardiovascular CV disturbances are mediated by antagonizing overdrive sympathetic nervous system SNS ). Methods Results Hypertensive patients with metabolic underwent laparoscopic Roux‐en‐Y gastric bypass surgery, spontaneously hypertensive rats SHR s) RYGB or sham surgery. Blood pressure BP ), heart rate HR endothelium‐dependent flow‐mediated dilation,...
Abstract High salt intake is a major risk factor for hypertension. Although acute caffeine produces moderate diuresis and natriuresis, increases the blood pressure (BP) through activating sympathetic activity. However, long-term effects of on urinary sodium excretion are rarely investigated. Here, we investigated whether chronic administration antagonizes sensitive hypertension by promoting excretion. Dahl salt-sensitive (Dahl-S) rats were fed with high diet or without 0.1% in drinking water...
p53-dependent vascular smooth muscle cell senescence is a key pathological process of abdominal aortic aneurysm (AAA). Caloric restriction (CR) nonpharmacological intervention that prevents AAA formation. However, whether p53 indispensable to the protective role CR remains unknown. In this study, we investigated necessity in beneficial formation and underlying mechanisms. We subjected p53+/+ p53-/- mice 12 weeks then examined incidence Ang II (angiotensin II)-induced found both knockout...
Background/Aims: Obesity and high salt intake are major risk factors for hypertension cardiometabolic diseases. Obese individuals often consume more dietary salt. We aim to examine the neurophysiologic effects underlying obesity-related intake. Methods: A multi-center, random-order, double-blind taste study, SATIETY-1, was conducted in communities of four cities China; an interventional study also performed local community Chongqing, using brain positron emission tomography/computed...
The renal proximal tubule (RPT) plays a pivotal role in regulating sodium reabsorption and thus blood pressure (BP). Transient receptor potential ankyrin 1 (TRPA1) has been reported to protect against injury by modulating mitochondrial function. We hypothesize that the activation of TRPA1 its agonist cinnamaldehyde may mitigate high-salt intake-induced hypertension inhibiting urinary through restoration tubular epithelial
Excessive salt consumption leads to cardiovascular diseases. Despite various measures designed reduce intake, daily intake remains at a high level. Appropriate is balanced by taste preference triggered epithelium sodium channel and aversion evoked bitter sensor, transient receptor potential M5 (TRPM5). However, the behavioral mechanism of excessive largely elusive. In this study, wild type TRPM5-/- mice were applied study influence high-salt administration on channel/TRPM5 associated...
Diabetic nephropathy (DN) is a major complication of diabetes mellitus and primary cause end-stage renal failure. Clinical studies indicate that metabolic surgery improves DN; however, the mechanism remains unclear. Here, we report Roux-en-Y Gastric Bypass (RYGB) significantly blocked reversed DN without affecting insulin signaling pathway. This protective role RYGB almost by either inhibition or knockout 5′AMP-activated protein kinase (AMPK) in podocytes. Furthermore, mRNA microarray data...