A5058630633- Osteoarthritis Treatment and Mechanisms
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Pulmonary Hypertension Research and Treatments
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Systemic Sclerosis and Related Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hepatitis B Virus Studies
- Gout, Hyperuricemia, Uric Acid
- Inflammatory mediators and NSAID effects
- Cancer-related gene regulation
- Biomarkers in Disease Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- TGF-β signaling in diseases
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Proteoglycans and glycosaminoglycans research
- Liver Diseases and Immunity
- Phagocytosis and Immune Regulation
- Drug-Induced Ocular Toxicity
- Protein Tyrosine Phosphatases
Nanchang University
2010-2025
First Affiliated Hospital of Nanchang University
2010-2025
Nanjing Drum Tower Hospital
2019-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Nanjing University
2019-2024
Guangzhou Medical University
2019-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2024
Chongqing Medical University
2011-2024
First Affiliated Hospital of Guangzhou Medical University
2019-2024
Kunming Medical University
2024
The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration drugs at thrombus site. Here, we develop one kind mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery thrombolytic anticoagulant treatment. Regulated by the special proteins on PM, target site then PM can be ruptured under near-infrared (NIR) irradiation to achieve desirable sequential drug release,...
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven synovitis exacerbates pathological process. However, precise therapies for macrophage to decrease and attenuate OA progression have been scarcely proposed. Transient receptor potential vanilloid 1 (TRPV1) a cation channel that has implicated pain perception inflammation. In this study, we investigated role TRPV1 polarization pathogenesis OA. We demonstrated expression infiltration were...
The microneedle (MN) provides a promising strategy for transdermal delivery of exosomes (EXO), in which the therapeutic effects and clinical applications are greatly reduced by fact that EXO can only partially reach injury site passive diffusion. Here, we designed detachable MN array to deliver modified nitric oxide nanomotor (EXO/MBA) Achilles tendinopathy (AT) healing. With releasing EXO/MBA, l-arginine was converted NOS or ROS as driving force. Benefiting from motion ability property MPC...
Neutrophil extracellular traps (NETs) are considered significant contributors to cancer progression, especially metastasis. However, it is still unclear whether NETs involved in hepatitis B virus (HBV)-related hepatocarcinogenesis and have potential clinical significance during evaluation management for hepatocellular carcinoma (HCC). In this study, we aimed investigate the functional mechanism of HBV-related their significance. A total 175 HCC patients with without HBV infection 58 healthy...
To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Patients were randomised (1:1:1) receive either placebo (n=188), ivarmacitinib 4 mg (n=189) or 8 once daily, background csDMARDs allowed. After 24 weeks, on switched for additional 28 while those continued their initial dosage....
Myeloid-derived suppressor cells (MDSCs) are a major component of the immunosuppressive tumor microenvironment (TME) and have been recognized as contributing factor to inflammation-related cancers. However, molecular mechanisms MDSCs accumulation activation still elusive. We previously showed that proinflammatory molecule S100A9 in TME exerts tumor-promoting effect colorectal carcinoma (CRC). In this report, we investigated on function CRC. Elevated were found tissue peripheral blood from...
Fusobacterium nucleatum (Fn) has been considered as a significant contributor in promoting colorectal carcinoma (CRC) development by suppressing host anti-tumor immunity. Recent studies demonstrated that the aggregation of M2 macrophage (Mφ) was involved CRC progress driven Fn infection. However, underlying molecular mechanisms are poorly characterized. Here, we investigated role Mφ polarization well its effect on malignancy. infection facilitated differentiation into M2-like phenotype vitro...
The fibrocartilage presented on the joint surface was caused by cartilage injury or degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we hypothesized that could be viewed as raw material renewal hyaline and proposed previously unidentified strategy regeneration, namely, “fibrocartilage hyalinization.” Cytoskeleton remodeling plays vital role in modifying cellular phenotype. We identified microtubule stabilization docetaxel repressed fibrosis increased...
Abstract Osteoarthritis (OA) is the most common form of arthritis. However, exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m 6 A) modification may have an important role in OA pathogenesis. This study aimed to investigate m A writers and underlying mechanisms osteoarthritic cartilage. Among methyltransferases, Wilms tumor 1-associated protein (WTAP) expression significantly differed clinical WTAP regulated extracellular matrix (ECM) degradation,...
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation transient receptor potential vanilloid 1 (TRPV1) significantly alleviated degeneration by abolishing chondrocyte ferroptosis. In this work, in view thermal activated feature TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) conjugated to TRPV1 monoclonal antibody...
Osteoarthritis (OA) is the most common degenerative joint disease, and its main pathological mechanism articular cartilage degeneration. The purpose of this study was to investigate role mitophagy in pathogenesis chondrocyte ferroptosis OA. expressions related proteins (GPX4, FTH1, COX2) ubiquitin-dependent (PARKIN, PINK1) intact injured areas OA were analyzed. Nitro oxide JP4-039, a mitochondrial targeting antioxidant, has bifunctional mitochondria. Then we evaluated potential protective...
Background and Objective S100A8 S100A9, two members of the S100 protein family, have been reported in association with tumor cell differentiation progression. Previous study has showed that their expression stromal cells colorectal carcinoma (CRC) is associated size. Here, we investigated clinical significances S100A9 CRC underlying molecular mechanisms. Methods Expression matching distal normal tissues were measured by reverse transcriptase polymerase chain reaction (RT-PCR),...
Osteoarthritis (OA), in which M1 macrophage polarization the synovium exacerbates disease progression, is a major cause of cartilage degeneration and functional disabilities. Therapeutic strategies OA designed to interfere with macrophages have rarely been reported. Here, we report that SHP099, as an allosteric inhibitor src-homology 2-containing protein tyrosine phosphatase 2 (SHP2), attenuated osteoarthritis progression by inhibiting polarization. We demonstrated was accompanied...
Osteoarthritis (OA) is a low-level inflammatory disease in which synovial macrophage M1 polarization exacerbates the progression of synovitis and OA. Notedly, ROS (reactive oxygen species) level macrophages intimately implicated polarization. TRPV4 (transient receptor potential channel subfamily V member 4), as an ion channel, plays pivotal role oxidative stress inflammation. In this study, we investigated OA Male adult Sprague-Dawley (SD) rats underwent medial meniscus radial transection...
Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) infection. Myeloid-specific S100 proteins (S100s), namely, S100A8, S100A9 and S100A12, have been recently recognized as newly discovered damage-associated molecular patterns (DAMPs) that are correlated progression in pathogen of infectious diseases. However, whether S100s regulated by HBV involved HBV-related hepatocarcinogenesis still unclear. Here, we found all expression levels myeloid-specific (S100A8, S10012) were...
Background: Treatment of cartilage lesions is clinically challenging. A previous study demonstrated that a hyaluronic acid hydrogel ( m-HA) with kartogenin (KGN)-loaded PLGA nanoparticles m-HA+KGN treatment) achieved superior repair in rabbit model. However, large animals serve as bridge to translate animal outcomes into the clinic. Hypotheses: (1) treatment could facilitate hyaline and subchondral bone tissue porcine (2) Defect size type (full-thickness chondral vs osteochondral) influence...
Oxidative stress-related cartilage degeneration, synovitis, and joint pain play vital roles in the progress of osteoarthritis (OA). Anti-oxidative stress agents not only prevent structural damage progression but also relieve OA-related pain. In this study, we investigated therapeutic effect methylene blue (MB), a classical important anti-oxidant with strong neural affinity. Experimental OA was established rats by radial transection medial collateral ligament meniscus (MCLT + MMT) right knee...
NLRP3 inflammasome-dependent pyroptosis has been implicated in liver fibrosis progression. However, the definite intrahepatic cell types that undergo and underlying mechanism as well clinical importance remain unclear. Here, augmented levels of pyroptosis-related indicators GSDMD, IL-1β, IL-18 were verified both patients CCl4-induced fibrotic mouse model. Confocal imaging with albumin, F4/80 or α-SMA revealed enhanced was mainly localized to kupffer cells (KCs), indicating KCs are major...
To detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn first phase of insulin secretion.A total 56 patients newly diagnosed type 2 diabetes mellitus, 36 impaired tolerance (IGT) 45 normal were enrolled. Intravenous tests carried out to evaluate pancreatic β-cell function. The adipsin, interleukin-1β high-sensitivity C-reactive protein assayed.Serum significantly lower mellitus IGT than those group (P < 0.05). acute...
Aims Osteoarthritis (OA) is a common degenerative joint disease worldwide, which characterized by articular cartilage lesions. With more understanding of the disease, OA considered to be disorder whole joint. However, molecular communication within and between tissues during process still unclear. In this study, we used transcriptome data reveal crosstalk different in OA. Methods We four groups transcription profiles acquired from Gene Expression Omnibus database, including cartilage,...
Purpose: Chondrocytes (CHs) in cartilage undergo several detrimental events during the development of osteoarthritis (OA).However, mechanism underlying CHs regeneration involved pathogenesis is largely unknown.The aim this study was to explore pathological condition and potential therapeutic strategies repair.Methods Materials: were isolated from human different OA stages high-resolution cellular architecture examined by applying single-cell RNA sequencing.The analysis gene differential...