A5101722466- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Cell death mechanisms and regulation
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Protease and Inhibitor Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Neuropeptides and Animal Physiology
- Bone and Joint Diseases
- Plant biochemistry and biosynthesis
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Ion Channels and Receptors
- Atrial Fibrillation Management and Outcomes
Zhejiang University
2015-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Tianjin Medical University
2016-2024
First Affiliated Hospital of Xiamen University
2023-2024
174th hospital of the People's Liberation Army
2024
Children's Hospital of Chongqing Medical University
2024
The University of Texas at Arlington
2021-2024
Chongqing Medical University
2024
Xiamen University
2004-2024
Apoptotic defects endow tumor cells with survival advantages. Such allow the cellular stress response to take path of cytoprotective autophagy, which either precedes or effectively blocks an apoptotic cascade. Inhibition autophagic shifts toward apoptosis, by interfering underlying molecular mechanism cytoprotection. The current study has identified such a that is centered on regulation caspase-8 activity. took advantage Bax(-/-) Hct116 are TRAIL-resistant despite significant DISC processing...
To examine the association of radiographic progression and disease activity states in patients with rheumatoid arthritis (RA) treated methotrexate or without infliximab.Patients (n = 1049) active RA for 3 years less no previous treatment were randomly assigned (4 : 5 5) to receive plus placebo infliximab 6 mg/kg at weeks 0, 2 6, every 8 thereafter week 46. Disease was classified by simplified index as remission (< =3.3), low (>3.3 < =11), moderate (>11 =26), high (>26). Radiographic measured...
Targeting TRAIL receptors with either recombinant or agonistic DR4- DR5-specific antibodies has been considered a promising treatment for cancer, particularly due to the preferential apoptotic susceptibility of tumor cells over normal TRAIL. However, realization that many tumors are unresponsive stimulated interest in identifying agents when used combination can sensitize TRAIL-mediated apoptosis. Our studies suggest various apoptosis defects block cell death at different points along...
M-CSF is a critical growth factor for myeloid lineage cells, including monocytes, macrophages, and osteoclasts. Tissue-resident macrophages in most organs rely on local M-CSF. However, it unclear what specific cells the bone marrow produce to maintain homeostasis. Here, we found that Adipoq-lineage progenitors but not mature adipocytes or peripheral adipose tissue, are major cellular source of M-CSF, with these producing at levels much higher than those produced by osteoblast cells. The high...
A series of neutral N-(substituted-benzamido)-N'-phenylthioureas (substituent = p-OC(2)H(5), p-CH(3), m-CH(3), H, p-Cl, p-Br, m-Cl, and p-NO(2)) were designed as anion receptors, in which the thiourea binding site was attached to benzamido moiety via an N-N bond. The absorption spectra these N-benzamidothioureas acetonitrile peaked at ca. 270 nm found show unprecedented red shifts by 7 373 14 325 cm(-1) presence anions such AcO(-), F(-), H(2)PO(4)(-). Under same conditions, classic...
Oxidized low-density lipoprotein (oxLDL)-induced injury and apoptosis of endothelial cells are important initial events in numerous cardiovascular diseases. Following activation by oxLDL, monocytes adhere to cells, migrate into the subendothelial spaces then undergo differentiation macrophages, which subsequently induces formation atherosclerotic lesions. However, mechanisms underlying macrophage oxLDL-treated remain unclear. In present study, it was demonstrated that exosomal...
Medical imaging provides quantitative and spatial information to evaluate treatment response in the management of patients with non-small cell lung cancer (NSCLC). High throughput extraction radiomic features on these images can potentially phenotype tumors non-invasively support risk stratification based survival outcome prediction. The prognostic value radiomics from different modalities time points prior during chemoradiation therapy NSCLC, relative conventional biomarker or delta models,...
Abstract Loss of refreshment in nucleus pulposus (NP) cellularity leads to intervertebral disc (IVD) degeneration. Nevertheless, the cellular sequence NP cell differentiation remains unclear, although an increasing body literature has identified markers progenitor cells (NPPCs). Notably, due their fragility, physical enrichment NP‐derived limited conventional transcriptomic approaches multiple studies. To overcome this limitation, a spatially resolved transcriptional atlas mouse IVD is...
Exosomes carry large cargo of proteins, lipids, and nucleic acids, serving as versatile biomarkers for disease diagnosis vehicles drug delivery. However, up to date, no well recognized standard procedures exosome storage were available clinical application. This study aimed determine the optimal conditions anticoagulants plasma-derived isolation. Fresh whole blood samples collected from healthy participants preserved in four different including sodium citrate (SC1/4), (SC1/9), lithium...
Transient potential receptor vanilloid 1 (TRPV1) channels, which are expressed on sensory neurons, elicit cardioprotective effects during ischemia reperfusion injury by stimulating the release of neuropeptides, namely calcitonin gene-related peptide (CGRP) and substance P (SP). Recent studies show that TRPV1 channels also cardiomyocytes can exacerbate air pollutant-induced apoptosis. However, whether these present directly modulate cell death survival pathways hypoxia/reoxygenation (H/R)...
Resveratrol (3,5,4-trihydroxystilbene, RES), a natural antioxidant, prevents bone loss by attenuating damage caused oxidative stress. Our previous research revealed that the forkhead box O1 (FoxO1)/β-catenin signaling pathway affected proliferation and differentiation of osteoblasts through its regulation redox balance, RES regulated expression FoxO1 to control white adipose tissue then ameliorate an overweight condition. Based on research, we hypothesized regulates transcriptional activity...
Background: We hypothesized that the transient receptor potential vanilloid type 1 (TRPV1), which is found in sensory nerve fibers, could modulate cardiac function, be impaired by diabetes and contribute to further severe postischemic heart injury. Methods Results: Diabetes was induced ICR mice an intraperitoneal injection of streptozotocin. The expression both TRPV1 calcitonin gene-related peptide (CGRP) mellitus (DM) hearts significantly lower, as determined Western blot radioimmunoassay,...