A5090175062- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- PARP inhibition in cancer therapy
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Traditional Chinese Medicine Analysis
- T-cell and B-cell Immunology
- Urinary and Genital Oncology Studies
- Congenital Heart Disease Studies
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Chemokine receptors and signaling
- Ion Channels and Receptors
- BRCA gene mutations in cancer
- Pulmonary Hypertension Research and Treatments
- Inflammatory mediators and NSAID effects
Jiangsu Province Hospital
2013-2024
Nanjing Medical University
2012-2024
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
Anhui Provincial Hospital
2020-2024
Jiangyin People's Hospital
2024
Xuzhou Medical College
2024
First Affiliated Hospital of Henan University of Science and Technology
2021-2024
First Affiliated Hospital of Bengbu Medical College
2018-2023
Zhejiang University
2023
Abstract Purpose: The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset patients with gliomas. Our hypothesis only most malignant gliomas have prominent glioma-infiltrating contributes immunosuppressive biology and presence Tregs negative prognostic variable. Experimental Design: We measured 135 glial tumors (including all pathologic types) glioma...
Transient receptor potential vanilloid family member 1 (TRPV1) has been revealed as a therapeutic target of osteoarthritis (OA), the most common deteriorating whole joint disease, by impeding macrophagic inflammation and chondrocytes ferroptosis. However, clinical application for capsaicin TRPV1 agonist is largely limited its chronic toxicity. To address this issue, we developed bifunctional controllable magnetothermal switch targeting alleviation OA progression coupling magnetic...
Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation transient receptor potential vanilloid 1 (TRPV1) significantly alleviated degeneration by abolishing chondrocyte ferroptosis. In this work, in view thermal activated feature TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) conjugated to TRPV1 monoclonal antibody...
Cytotoxic chemotherapy that induces lymphopenia is predicted to ablate the benefits of active antitumor immunization. Temozolomide an effective chemotherapeutic agent for patients with glioblastoma multiforme, but it significant lymphopenia. Although there monthly fluctuation white blood cell count, specifically CD4 and CD8 counts, was no cumulative decline in patient described this case report. Depriving agent, order treat immunotherapy, controversial. Despite conventional dogma, we...
Abstract Purpose: Activation of signal transducers and activators transcription 3 (STAT3) has been identified as a central mediator melanoma growth metastasis. We hypothesized that WP1066, novel STAT3 blockade agent, marked antitumor activity, even against the metastasis to brain, site typically refractory therapies. Experimental Design: The activities related mechanisms WP1066 were investigated both in vitro on cell lines vivo mice with subcutaneously syngeneic or intracerebral tumors....
NAT10 (also known as human N-acetyltransferase-like protein) is a critical gene that regulates N4-acetylcytidine formation in RNA, similar to the multiple regulators of N6-methyladenosine. However, underlying functions and mechanisms tumor progression immunology are unclear.In this study, we systematically analyzed pan-cancer expression correlations NAT10, using databases including Oncomine, PrognoScan, GEPIA2, Kaplan-Meier Plotter. The potential with immune infiltration stages marker sets...
Abstract Purpose: In patients with platinum-sensitive relapsed (PSR) ovarian cancer, olaparib maintenance monotherapy significantly improves progression-free survival (PFS) versus placebo. However, evidence in the Asian population is lacking. This first study to evaluate efficacy and tolerability exclusively PSR cancer. Patients Methods: Considering limited placebo effect significant clinical benefit of previous trials, rapid approval China, this phase III was designed as an open-label,...
Raddeanin A is one of the triterpenoid saponins in herbal medicine Anemone raddeana Regel which was reported to suppress growth liver and lung cancer cells. However, little known about its effect on gastric (GC) This study aimed investigate inhibitory three kinds different differentiation stage GC cells (BGC-823, SGC-7901 MKN-28) vitro possible mechanisms. Proliferation assay flow cytometry demonstrated A's dose-dependent determined induction apoptosis, respectively. Transwell assay,...
Endometrial carcinoma represents one of the most common cancer types female reproductive tract. If diagnosed at an early stage, 5-year survival rate is promising. However, recurrence and chemoresistance remain problematic for least 15% patients. In present study, we aim to reveal mechanism by which PGK1 regulates in endometrial carcinoma. qPCR was performed detect expression clinical tissue samples Specific shRNAs were employed knockdown cell lines. MTT assay used evaluate viability...
A variety of pathogenic microorganisms can promote the occurrence and development malignant tumors by colonizing in body. It has been shown that Porphyromonas gingivalis (P. gingivalis) be colonized for a long time upper gastrointestinal is closely related to esophageal cancer previous studies our team. Because esophagus trachea are adjacent P. instantly enter colonize cells, we speculate may lung cells through oral or blood, promoting progression cancer. In this study, investigated...
Aims Osteoarthritis (OA) is a common degenerative joint disease worldwide, which characterized by articular cartilage lesions. With more understanding of the disease, OA considered to be disorder whole joint. However, molecular communication within and between tissues during process still unclear. In this study, we used transcriptome data reveal crosstalk different in OA. Methods We four groups transcription profiles acquired from Gene Expression Omnibus database, including cartilage,...
Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure, leading to right ventricular failure and death. Pathogenic features of PH include endothelial apoptosis inflammation, which drive remodeling increased pressure. Re-analysis the whole transcriptome sequencing comparing human cells (PAECs) isolated from control patients identified AREG , encodes Amphiregulin, as key survival factor. PAECs mice exhibited down-regulation its receptor...
Abstract Purpose: Phase I results of this phase I/II study showed that pamiparib 60 mg twice a day had antitumor activity and an acceptable safety profile in Chinese patients with advanced cancer, including epithelial ovarian cancer. Patients Methods: This open-label II was conducted China enrolled adult (≥18 years) platinum-sensitive cancer (PSOC; disease progression occurring ≥6 months after last platinum treatment) or platinum-resistant (PROC; <6 treatment). Eligible known...
Abstract Objectives : This study was designed to determine the safety and efficiency of asymmetric symmetric ventricular septal occluders (AVSDOs SVSDOs, respectively) for closure perimembranous defect (PMVSD) in children. Methods Between January 2003 December 2007, 142 children with PMVSD were treated (64 AVSDOs 78 SVSDOs). Results The diameter 5.3 ± 1.1 mm AVSDO group 5.4 1.3 SVSDO ( P > 0.05). success rates similar between two groups [93.8% (AVSDO) vs. 94.9% (SVSDO), 0.05]. Two...
Abstract Background Dysfunction of vascular endothelium is implicated in many pathological situations. Cytoskeleton plays an importance role endothelial permeability barrier and inflammatory response. Many Chinese herbs have the protective effect, which, “ Astragalus membranaceus ” a highly valued herb for treatment cardiovascular renal diseases traditional medicine, In this study, we tested whether calycosin-7-O-β-D-glucoside (Calycosin), main effective monomer component ”, could protect...
Myosin heavy chain 11 (MYH11), encoded by the MYH11 gene, is a protein that participates in muscle contraction through hydrolysis of adenosine triphosphate. Although previous studies have demonstrated gene expression levels are downregulated several types cancer, its rarely been investigated lung cancer. The present study aimed to explore clinical significance and prognostic value cancer further underlying molecular mechanisms function this gene. Oncomine database showed were decreased...
Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. In this study, we examined presence Porphyromonas gingivalis ( P. ) in oral-digestive tract tumors by immunohistochemistry (IHC) PCR analyzed correlation detection clinicopathological characteristics prognosis oral esophageal carcinoma. The IHC results showed that positive rates were 60.00, 46.00, 20.00, 6.67, 2.86% oral, esophagus, cardiac, stomach, colorectal...