A5080528387- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Parasites and Host Interactions
- Tryptophan and brain disorders
- Advanced Photocatalysis Techniques
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Advanced Battery Materials and Technologies
- Advanced biosensing and bioanalysis techniques
- Treatment of Major Depression
- Advanced Nanomaterials in Catalysis
- Molten salt chemistry and electrochemical processes
- Chromatography in Natural Products
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- Pancreatic and Hepatic Oncology Research
- Sulfur Compounds in Biology
- Carbon and Quantum Dots Applications
- Chemical Looping and Thermochemical Processes
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- NF-κB Signaling Pathways
- Advancements in Battery Materials
- Macrophage Migration Inhibitory Factor
Nanjing Medical University
2012-2025
Jiangsu Province Hospital
2019-2025
Guangzhou Medical University
2014-2024
Xuzhou Medical College
2015-2024
China State Shipbuilding (China)
2024
Eindhoven University of Technology
2024
Nanjing University of Chinese Medicine
2015-2023
Second Xiangya Hospital of Central South University
2023
Central South University
2023
Hunan Institute of Engineering
2023
Strawberry (Fragaria × ananassa Duch), a fruit of economic and nutritional importance, is also model species for fleshy fruits genomics in Rosaceae. quality at different harvest stages function the fruit's metabolite content, which results from physiological changes during growth ripening. In order to investigate strawberry development, untargeted (GC-MS) targeted (HPLC) metabolic profiling analyses were conducted. Principal component analysis (PCA) partial least squares discriminant...
Abstract Yueju, a Traditional Chinese Medicine formula, exhibited fast-onset antidepressant responses similar to ketamine. This study focused on assessing the rapid and persistent efficacy of Yueju ketamine in chronically stressed mice its association with alternations prefrontal N-methyl-D-aspartate (NMDA) receptor mammalian target rapamycin (mTOR)-related activity. Chronic mild stress (CMS) led deficits sucrose preference test (SPT), forced swim test, tail suspension novelty-suppressed...
Controllable in situ formation of nanoclusters with discrete active sites is highly desirable heterogeneous catalysis. Herein, a titanium oxide–based Fenton-like catalyst constructed using exfoliated Ti 3 C 2 MXene as template. Theoretical calculations reveal that redox reaction between the surface Ti-deficit vacancies and H O molecules facilitates conversion defects into oxide anchoring on amorphous carbon (TiO x @C). The presence mixed-valence δ+ (δ = 0, 2, 3, 4) within TiO @C confirmed by...
Despite growing evidence that has declared the importance of circRNAs in neurodegenerative diseases, clinical significance dopaminergic (DA) neuronal degeneration pathogenesis Parkinson disease (PD) remains unclear. Here, we performed rRNA-depleted RNA sequencing and detected more than 10,000 plasma samples PD patients. In consideration ROC correlation between Hohen-Yahr stage (H-Y stage) Unified Disease Rating Scale-motor score (UPDRS) 40 patients,
Patients with Type 2 diabetes mellitus(T2DM) typically have an average or higher bone mineral density (BMD) but are at a significantly risk of fracture than patients without diabetes. Trabecular score (TBS) is textural index derived from pixel gray-level variations in lumbar spine DXA image, which has been introduced as indirect measure quality. This study aimed to discuss the trends and annual rates change BMD TBS age Chinese men T2DM mellitus. Lumbar spine(LS) was lower males compared...
Recently, the worldwide demand for romaine lettuce (Lactuca sativa L.) has been increasing. Thus, regulation measures of supplementary or shading light are often used in production some regions. However, inconsistent results on saturation point from previous studies do not facilitate intensity. In present study, effects different intensities anti-oxidative enzyme activity, yield and quality were investigated. The reveal following: (1) judged by dynamics there was no stress to occurr 100, 200...
Aims: Hydrogen sulfide (H2S), a novel gaseous mediator, has been recognized to protect neurons from overexcitation by enhancing the activity of adenosine triphosphate-sensitive potassium (K-ATP) channel. However, no direct evidence supports that K-ATP channel contributes neuroprotective effect H2S in neurodegeneration. Herein, wild-type and Kir6.2 knockout (Kir6.2−/−) mice were used establish 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Parkinson's disease (PD) so as...
Efficient and high-flux capture of CO2 is the prerequisite its utilization. Static absorption with solid Li2O molten salts (Li2O-free Li2O-containing Li-Na-K carbonates) was investigated using a reactor in situ pressure monitoring. The capacity dissolved 0.835 molCO2/molLi2O at 723 K, larger than that Li2O. For absorbents, formation Li2CO3 on surface can retard further reactions between CO2, whereas dissociation/dissolution effect carbonate improved mass-specific liquid In carbonate, mostly...
Electrochemical transformation of CO<sub>2</sub>into functional materials or fuels (<italic>i.e.</italic>, carbon, CO) in high temperature molten salts has been demonstrated as a promising way carbon capture, utilisation and storage (CCUS) recent years. In view continuous operation, the electrolysis process should match very well with CO<sub>2</sub>absorption kinetics. At same time, consideration energy efficiency, salt electrochemical cell running at lower is more beneficial to powered by...
Parkinson's disease (PD) is a common chronic neurodegenerative and greatly affects the quality of PD patients' life. Current symptomatic treatment limited. There are no effective drugs that could radically cure PD. Increasing experimental evidence has proven causal relationship between alpha-synuclein (α-synuclein, α-syn) neuropathology diseases, although exact pathophysiological role α-synuclein not fully clarified. Previous studies showed monomers polymers were secreted from damaged nerve...
Objective . To study the protective effect of Echinacoside for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopaminergic (DA) neurons injury in subacute mouse model Parkinson’s disease (PD) and to explore its mechanism action. Methods We chose 10 weeks healthy wild type C57BL/6 male mice, hypodermic MPTP 30 mg/kg/day, five days, prepare PD model. Behavior indexes open field test pole were applied examine function ECH mice sample The effects on astrocyte examined using...
Abstract Postpartum depression (PPD) affects over 10% of new mothers and adversely impacts the health offspring. One greatest risk factors for PPD is prepregnancy stress but underlying biological mechanism unknown. Here we constructed an animal model which recapitulated induced tested role Akt-mTOR signaling in hippocampus. Female virgin Balb/c mice received chronic restraint stress, followed by co-housing with a normal male mouse. We found that led to transient depressive-like condition...
Endometrial carcinoma represents one of the most common cancer types female reproductive tract. If diagnosed at an early stage, 5-year survival rate is promising. However, recurrence and chemoresistance remain problematic for least 15% patients. In present study, we aim to reveal mechanism by which PGK1 regulates in endometrial carcinoma. qPCR was performed detect expression clinical tissue samples Specific shRNAs were employed knockdown cell lines. MTT assay used evaluate viability...
Abstract Background Hepatic stellate cell (HSC) activation plays a pivotal role in hepatic inflammation and liver fibrosis. TLR4 pathway has been reported to be involved mice fibrosis induced by hepatitis virus infection, alcohol abuse, biliary ligation, carbon tetrachloride 4 treatment, Schistosoma japonicum ( Sj ) infection. The effect mechanisms of the cyclooxygenase 2 (COX2)/prostanoid E2 (PGE2) axis on are still unclear. Methods Mice were cutaneous infection cercariae. COX-2 inhibitor,...