A5063371871- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Bone health and osteoporosis research
- Hormonal Regulation and Hypertension
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Acute Myocardial Infarction Research
- Dietary Effects on Health
- Bone health and treatments
- Venous Thromboembolism Diagnosis and Management
- Gut microbiota and health
- Extracellular vesicles in disease
- Neutropenia and Cancer Infections
- Barrier Structure and Function Studies
- Cancer Risks and Factors
- COVID-19 and healthcare impacts
- Cardiovascular and exercise physiology
- RNA Interference and Gene Delivery
- Cardiac tumors and thrombi
- Aldose Reductase and Taurine
- Ion Transport and Channel Regulation
- Apelin-related biomedical research
- Estrogen and related hormone effects
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2018-2025
Traditional Chinese Medicine Hospital of Kunshan
2023-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Soochow University
2021-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2021-2023
Northwestern University
2012
Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a role in the pathogenesis of GC-induced accumulation. Overexpression miR-27b had same effects as dexamethasone (DEX) on inhibition brown adipose differentiation energy expenditure primary adipocytes. Conversely, antagonizing function prevented DEX suppression expression tissue–specific genes. GCs transcriptionally regulate through GC...
A high‑fat diet (HFD) or obesity‑promoting is closely associated with metabolic diseases and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The epithelium constitutes a barrier that separates the host from food microbiota gut, thus, dysfunctional number of diseases. However, changes caused to function response an HFD have not been well‑studied date. In present study, female mice (12 months old) fed for period 14 weeks were used determine effects on...
Patients with Type 2 diabetes mellitus(T2DM) typically have an average or higher bone mineral density (BMD) but are at a significantly risk of fracture than patients without diabetes. Trabecular score (TBS) is textural index derived from pixel gray-level variations in lumbar spine DXA image, which has been introduced as indirect measure quality. This study aimed to discuss the trends and annual rates change BMD TBS age Chinese men T2DM mellitus. Lumbar spine(LS) was lower males compared...
Summary Calorie restriction ( CR ) increases average and maximum lifespan exhibits an apparent beneficial impact on age‐related diseases. Several studies have shown that initiated either in middle or old age could improve ischemic tolerance rejuvenate the aging heart; however, data are not uniform when young. The accurate time to initiate providing benefits for cardiac remodeling function during remains unclear. Thus, whether a similar degree of mice different ages exert effect myocardial...
Abstract Cancer cachexia is a complex syndrome that associated with thermogenic gene regulation. Currently, although some studies have reported the link between exosomes and cancer in few types of cancer, underlying mechanisms remain poorly understood. In this study, we tried to identify whether derived from colorectal could affect lipolysis vitro vivo. Here, collected tissue samples 48 patients (47.91% females mean age 55 ± 8.20) healthy people at First Affiliated Hospital Nanjing Medical...
Clinical evidence shows that visceral fat accumulation decreases whereas sc increases in patients treated with thiazolidinediones (TZDs), a type of peroxisome proliferator-activated receptor (PPAR)γ agonist. To clarify the molecular mechanism differential effects PPARγ agonists on and adipose, we investigated expression profiling PPARγ-regulated micro-RNAs (miRNAs) using miRNA microarray. The level 182 miRNAs changed human adipose pioglitazone, only 46 adipose. Among these miRNAs, 27 both...
Background and aim Patients diagnosed with cancer, particularly those hematologic malignancies, frequently exhibit a state of immunosuppression. Currently, there remains scarcity dependable biomarkers for assessing the severity COVID-19 in individuals malignancies. We conducted retrospective study morbidity mortality patients hematological malignancies (HM) who had contracted COVID-19. The was to offer reference clinical diagnosis treatment. Methods A total 71 HM-confirmed were enrolled from...
Brown adipose tissue (BAT) increases energy expenditure and is an attractive therapeutic target for obesity. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), amplifier of local glucocorticoid activity, has been shown to modulate white (WAT) metabolism function. In this study, we investigated the roles 11β-HSD1 in regulating BAT We observed a significant increase expression BAT-specific genes, including UCP1 , Cidea Cox7a1 Cox8b BVT.2733 (a selective inhibitor 11β-HSD1)-treated...
Whether fat is beneficial or detrimental to bones still controversial, which may be due inequivalence of the mass. Our objective define effect body and its distribution on bone quality in healthy Chinese men. A total 228 men, aged from 38 89 years, were recruited. BMD, trabecular score (TBS), measured by dual-energy X-ray absorptiometry. Subcutaneous visceral assessed MRI. In Pearson correlation analysis, lumbar spine BMD exhibited positive associations with all regional depots, regardless...
Background Inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is being pursued as a new therapeutic approach for the treatment obesity and metabolic syndrome. Therefore, there an urgent need to determine effect 11β-HSD1 inhibitor, which suppresses glucocorticoid action, on adipose tissue inflammation. The purpose present study was examine BVT.2733, selective expression pro-inflammatory mediators macrophage infiltration in C57BL/6J mice. Methodology/Principal Findings mice were...
Objective: Long-term dysregulation of energy balance is the key component obesity epidemic. Given harm central and discovery that beige cells appear within white adipose tissue (WAT), enhancing energy-expending or "browning" ability visceral (VAT) has become therapeutic interest. In this study, we focused on regulating role microRNA (miRNA)-27b-3p in mice epididymal (eWAT) browning. Methods: High-fat diet (HFD) induced obese model was constructed. Expression miR-27b-3p Ucp1 eWAT measured...
Current pharmacological treatments for obesity and metabolic syndrome have various limitations. Recently, adipose tissue 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a novel therapeutic target the treatment of syndrome. Nevertheless, there is no tissue-targeted 11β-HSD1 inhibitor available now. We sought to develop new that homes specifically white aimed investigate whether might decrease body weight gain improve glucose tolerance in diet-induced mice. BVT.2733, an...
This study was designed to explore age-related changes in trabecular bone score (TBS) and mineral density (BMD) Chinese men through cross-sectional longitudinal studies.We included adult who had at least twice TBS BMD examinations our hospital between January 2013 December 2020. All were divided into an age subgroup per 10 years, comparing differences baseline lumbar spine (LS) various parts each group analyzing during follow-up.Baseline data showed that aged 36 85 the hip region a...
Given the rising prevalence of central obesity and discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" depots have become therapeutic interest combat its associated disorders. This study focused on, role microRNA (miRNA)-27b-3p in human visceral tissue (VAT) browning. Expression miR-27b-3p UCP1 VAT serum humans was measured. MiR-27b-3p overexpressed suppressed stromal fraction analyze potential miR-27b-3p....
Studies on the relationship between obesity and bone have recently become widespread. The aim of this study was to investigate effect bone, utilizing a diet-induced obese mouse model, explore role free fatty acids (FFAs) in osteogenesis/adipogenesis marrow-derived mesenchymal stem cells (BMSCs). An model established by high-fat diet (HFD). Proximal femurs were collected at sacrifice, mineral density (BMD) proximal measured dual-energy X-ray absorptiometry. Bone histomorphometry performed...
Pharmacologic glucocorticoids (GCs) inhibit osteoblast function and induce osteoporosis. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) may play a role in osteoporosis as it regulates GC action at pre-receptor level by converting inactive to its active form. Further, 11β-HSD1 was found increasingly expressed bone with age. In spite of these obervations, senile remains uncertain. this study we constructed lentiviral vector overexpressing mouse then MC3T3-E1 preosteoblast cells were...
Venous thromboembolism(VTE) is a leading cause of death in patients with lung cancer. Furthermore, hospitalization advanced cancer for VTE treatment represents major economic burden on the national public health resources. Therefore, we performed this prospective study to identify clinical biomarkers early identification patients.This enrolled 158 confirmed cancer, including 27 who were diagnosed within six months follow-up after diagnosis. Multivariate logistic regression analysis was used...
Age-related alterations in whole body composition, particularly, reduced fat free mass (FFM) and increased (FM), lead to a progressive decline resting energy expenditure (REE). Similarly, regional composition distribution changes with age might also contribute an overall lower REE. This study investigated the influence of on REE, distribution, including subcutaneous (SF) visceral (VF), Chinese Han population as well their contributions age-related One hundred two males aged 31-83 years old...
This study aimed to reveal the impact of energy restriction on intestine via structural and molecular changes in terms intestinal stem cell (ISC) function, ISC niche, epithelial barrier immune function. Female C57BL/6J mice, aged 12 months, fed a commercial chow were used this study. The function assessed. Energy reversed aging-induced shortening made crypts shallower. cells isolated from showed significant increase expression levels cell-associated genes small as detected by flow cytometry....