A5100614833- Adipose Tissue and Metabolism
- DNA Repair Mechanisms
- Toxic Organic Pollutants Impact
- Hormonal Regulation and Hypertension
- Land Use and Ecosystem Services
- Adipokines, Inflammation, and Metabolic Diseases
- Marine and coastal ecosystems
- RNA modifications and cancer
- Environmental Changes in China
- Aquatic Ecosystems and Phytoplankton Dynamics
- Wastewater Treatment and Nitrogen Removal
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Cardiovascular Disease and Adiposity
- Estrogen and related hormone effects
- Constructed Wetlands for Wastewater Treatment
- Tryptophan and brain disorders
- Per- and polyfluoroalkyl substances research
- Water Quality Monitoring Technologies
- Hydrology and Watershed Management Studies
- Insect Resistance and Genetics
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Nutrition and Health in Aging
- Diet and metabolism studies
Nanjing Medical University
2016-2025
Capital Medical University
2025
Beijing Friendship Hospital
2025
Jiangsu Cancer Hospital
2025
Zhuhai People's Hospital
2025
Chinese Academy of Sciences
2008-2024
Jiangsu Province Hospital
2013-2024
Institute of Applied Ecology
2024
University of Chinese Academy of Sciences
2017-2024
Northeast Institute of Geography and Agroecology
2017-2024
Emerging evidence suggests that the gut microbiota may interact with host brain and play pivotal roles in pathogenesis of neuropsychiatric disorders. However, mechanism underlying reciprocal interactions along microbiota-gut-brain axis depression remains unclear. In this study, a murine model chronic restraint stress (CRS) was established to investigate metabolic signaling tryptophan (Trp) neurotransmission at intestinal central levels depression. The results showed CRS mice displayed...
Abstract Background Adolescent depression is becoming one of the major public health concerns, because its increased prevalence and risk significant functional impairment suicidality. Clinical commonly emerges in adolescence; therefore, prevention intervention at this stage crucial. Recent evidence supports importance gut microbiota (GM) modulation multiple functions associated with through gut-brain axis (GBA). However, underlying mechanisms remain poorly understood. Therefore, current...
Long-term glucocorticoid (GC) treatment induces central fat accumulation and metabolic dysfunction. We demonstrate that microRNA-27b (miR-27b) plays a role in the pathogenesis of GC-induced accumulation. Overexpression miR-27b had same effects as dexamethasone (DEX) on inhibition brown adipose differentiation energy expenditure primary adipocytes. Conversely, antagonizing function prevented DEX suppression expression tissue–specific genes. GCs transcriptionally regulate through GC...
A high‑fat diet (HFD) or obesity‑promoting is closely associated with metabolic diseases and intestinal tumors, particularly in middle‑aged individuals (typically 45‑64 years old). The epithelium constitutes a barrier that separates the host from food microbiota gut, thus, dysfunctional number of diseases. However, changes caused to function response an HFD have not been well‑studied date. In present study, female mice (12 months old) fed for period 14 weeks were used determine effects on...
2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation (ABTS*+) is a stable free frequently used for estimating the total antioxidant capacity (TAC) of natural products. The existing methods ABTS*+ radical-scavenging activity assays are diverse in pre-diluting solvents and reaction time, which lead to errors TAC estimations. To develop an effective universal method accurately reasonably, five pre-dilution [methanol, ethanol, phosphate buffer (Na2HPO4-NaH2PO4,...
The objective of the present study was to investigate whether associations exist between inflammatory biomarkers and all-cause mortality cardiovascular disease (CVD) in women with postmenopausal osteoporosis (PMOP) or osteopenia.In this retrospective cohort study, data were obtained from National Health Nutrition Examination Survey database years 2007 2010, 2013 2014, 2017 2018. including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR), neutrophil ×...
Abstract Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony social development. aetiology complex. In recent years, many scholars found that its pathogenesis was related to imbalance gut microbiota. Gut microbiota can form two‐way communication with brain through ‘gut‐brain axis’ affect host's metabolism. Current research...
Summary Calorie restriction ( CR ) increases average and maximum lifespan exhibits an apparent beneficial impact on age‐related diseases. Several studies have shown that initiated either in middle or old age could improve ischemic tolerance rejuvenate the aging heart; however, data are not uniform when young. The accurate time to initiate providing benefits for cardiac remodeling function during remains unclear. Thus, whether a similar degree of mice different ages exert effect myocardial...
Mammary fat is the main composition of breast, and most probable candidate to affect tumor behavior because produces hormones, growth factors adipokines, a heterogeneous group signaling molecules. Gene expression profiling functional characterization mammary in Chinese women has not been reported. Thus, we collected tissues adjacent breast tumors from 60 subjects, among which 30 subjects had cancer benign lesions. We isolated cultured stromal vascular cell fraction fat. The genes related...
Handgrip strength (HGS), which represents global muscle strength, is a powerful indicator of disability and mortality in older adults; it also used for the diagnosis possible- or probable- sarcopenia physical frailty. This study aimed to explore metabolic mechanisms potential biomarkers associated with declining HGS among adults. We recruited 15 age- environment-matched inpatients (age, 77â90 years) low normal HGS. Liquid chromatography-mass spectrometry (LC-MS) 16S ribosomal DNA (rDNA)...
Abstract Objective This study aims to construct a clinical risk profile nomogram model for predicting early shoulder joint dysfunction (SJD) after breast cancer surgery. Methods Using convenience sampling method, the data of 161 patients between February 2022 and July 2023 at Affiliated Cancer Hospital Nanjing Medical University were selected analyzed retrospectively. Risk factors identified using univariate multivariate logistic regression analyses. The R software was used prediction plot...
This letter addresses Wang and Zhang's investigation into the role of tankyrase 2 (TNKS2) as a pivotal driver malignancy in non-small cell lung cancer (NSCLC) through mechanisms including apoptosis inhibition, enhanced cellular migration, β-catenin pathway activation. Their study NSCLC lines demonstrates that TNKS2 overexpression stabilizes β-catenin, subsequently triggering oncogenic gene expression facilitating migration-key attributes metastatic potential. These insights position...
In this study, remote sensing data of Wuhan City, Hubei Province, China in 1996–2001 were selected to extract wetland landscape information. Several indices used evaluate the changes pattern within five years, including patch number, density, fractal dimension, diversity, dominance, evenness, and fragmentation indexes. Then, transformation probabilities landscapes into non-wetland calculated based on Markov Model, these grounds relationship between urban construction was analyzed. The...