A5002437368- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Bone Metabolism and Diseases
- Inflammasome and immune disorders
- Bone health and osteoporosis research
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Macrophage Migration Inhibitory Factor
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Vitamin D Research Studies
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- IL-33, ST2, and ILC Pathways
- Biomarkers in Disease Mechanisms
- Nutrition and Health in Aging
- Osteoarthritis Treatment and Mechanisms
First Affiliated Hospital of Anhui Medical University
2016-2025
Anhui Medical University
2016-2025
Huashan Hospital
2025
Fudan University
2025
Jingzhou Central Hospital
2025
Yangtze University
2025
China Development Bank
2025
Lishui City People's Hospital
2015-2024
Nanjing University of Chinese Medicine
2024
McMaster University Medical Centre
2010
To assess the efficacy/safety of ivarmacitinib, a selective Janus kinase (JAK) 1 inhibitor, in patients with moderate-to-severe active rheumatoid arthritis (RA) who had an inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Patients were randomised (1:1:1) receive either placebo (n=188), ivarmacitinib 4 mg (n=189) or 8 once daily, background csDMARDs allowed. After 24 weeks, on switched for additional 28 while those continued their initial dosage....
Immunotherapy has improved considerably the treatment outcomes in rheumatoid arthritis (RA).Tumor necrosis factor (TNF)-α antagonists have been widely used for of RA such as infliximab, etanercept, adalimumab and recent two new TNF-α inhibitors -certolizumab pegol golimumab.Infliximab, a chimeric monoclonal antibody, binds with high affinity specificity to human TNF cancels out its biologic activity.Etanercept is also but it solute protein.Adalimumab recombinant IgG antibody specific...
Objectives: To explore the associations between serum adipokine levels, radiographic osteoarthritis (ROA) severity, and articular cartilage volume in patients with knee OA.Method: A cross-sectional sample of 205 (aged 45–74 years) OA were consecutively recruited to Anhui Osteoarthritis (AHOA) study. ROA was assessed using Kellgren–Lawrence (KL) grading system (grades 0–4). Knee determined fat-saturated T1-weighted magnetic resonance imaging (MRI). Serum levels adipokines leptin, adiponectin,...
Introduction: This study presents an innovative arthroscopy-assisted total wrist arthrodesis technique utilising three hollow screws, aimed at improving clinical outcomes for patients with severe arthritis. Materials and methods: The involved the placement of screws to facilitate bone fusion. Between August 2019 2023, four diagnosed arthritis underwent procedure. Each patient was followed postoperatively least 1 year. Clinical evaluations included Visual Analogue Scale (VAS), Quick...
Seed science has undergone transformative advancements through the integration of microbial technologies, with beneficial microorganisms emerging as critical tools for enhancing germination, seedling vigor, and crop resilience. Research demonstrates that treatments improve nutrient uptake, hormonal regulation, stress tolerance while establishing early symbiotic relationships plants. This review synthesized recent advances in understanding roles microbes seed science, focusing on their impact...
Background Long non-coding RNAs (lncRNAs) are gaining recognition for their critical involvement in diverse autoimmune disorders. Nevertheless, reseach investigating the role of lncRNAs rheumatoid arthritis (RA) is relatively scarce. Methods Comprehensive transcriptome sequencing was executed to acquire a lncRNA expression pattern peripheral blood mononuclear cells (PBMC) RA. Then, we confirmed data by real-time quantitative polymerase chain reaction (RT-qPCR). Results The findings showed...