A5039954132- Hormonal and reproductive studies
- Obesity and Health Practices
- Phytochemical compounds biological activities
- Medicinal Plant Pharmacodynamics Research
- Endometrial and Cervical Cancer Treatments
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Enhanced Recovery After Surgery
- Reproductive tract infections research
- Sphingolipid Metabolism and Signaling
- Ion Channels and Receptors
- Proteoglycans and glycosaminoglycans research
- Gout, Hyperuricemia, Uric Acid
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Animal Genetics and Reproduction
- Gastrointestinal motility and disorders
- Sexuality, Behavior, and Technology
- Protease and Inhibitor Mechanisms
- Natural product bioactivities and synthesis
- Ovarian cancer diagnosis and treatment
- Nicotinic Acetylcholine Receptors Study
- Eating Disorders and Behaviors
- Fibroblast Growth Factor Research
First Affiliated Hospital of Jinan University
2017-2025
Cisplatin (DDP) is currently one of the most commonly used chemotherapeutic drugs for treating ovarian and lung cancer. However, resistance to cisplatin common it often leads therapy failure. In addition, precise mechanism still in its infancy. this study, we demonstrated that oxidative pentose phosphate pathway enzyme 6-phosphogluconate dehydrogenase (6PGD) promotes resistance. We showed cisplatin-resistant cancer cells (C13∗ A549DDP), had higher levels 6PGD compared their...
Fibroblast growth factor receptors (FGFRs) have been implicated in the malignant transformation and chemoresistance of epithelial ovarian cancer; however, underlying molecular mechanisms are poorly understood. Increased sialyltransferase activity that enhances protein sialylation is an important post‑translational process promoting cancer progression malignancy. In present study, α2,6‑sialyltransferase (ST6Gal‑I) overexpression or knockdown cell lines were developed, FGFR1 was examined to...
In China, research on the mental health of transgender populations is increasingly prevalent; however, there a lack localized psychological measurement tools that align with characteristics this population. The Transgender Congruence Scale (TCS) widely used internationally. This study aims to assess reliability, validity, and psychometric Chinese version TCS among sample. A total 264 participants mean age 24.88 (SD = 5.91) were recruited from October 2023 January 2024. They completed TCS,...
Ovarian cancer (OC) is the most lethal of all gynecologic malignancies with poor survival rates. Although surgical treatment and chemotherapy had advanced to improve survival, platinum-based chemoresistance remains a major hurdle in clinical OC. The search for novel active ingredients drug-resistant OC urgently needed. Here, we demonstrated that icaritin, main ingredient derived from traditional Chinese herb Epimedium genus, significantly suppressed proliferation, migration, invasion both...
Abstract Background There is insufficient research on how gender-affirming hormone therapy (GAHT) affects body fat modifications in transwomen from China. It unclear whether the prevalence of obesity and blood lipid levels within this population. The current aimed to assess GAHT treatment duration had an impact change redistribution Chinese transwomen. Methods This study included 40 who not received 59 had. Body fat, lipid, glucose were measured. mainly a pharmacologic (estrogen...
Pyroptosis is a newly identified form of cell death, morphologically characterized by excessive swelling. In the present study, paclitaxel (PTX) combined with platinum were used as first‑line chemotherapy, against ovarian cancer cells inducing multiple types death. However, it remains unclear whether PTX can induce pyroptosis in cells. It was recently reported that inhibited chloride channels, an inhibition known to cause first verified pyroptosis‑like well cleaved‑caspase‑3 and...
Epithelial ovarian cancers (EOC) present as malignant tumors with high mortality in the female reproductive system diseases. Acquired resistance to paclitaxel (PTX), one of first-line treatment EOC, remains a therapeutic challenge. ClC-3, member voltage-gated Cl- channels, plays an essential role variety cellular activities, including chemotherapeutic resistance. Here, we demonstrated that protein expression and channel function ClC-3 was upregulated PTX A2780/PTX cells compared its parental...
The vaginal microbiota, dominated by Lactobacilli, plays an important role in maintaining women's health. Disturbance of the microbiota allows infection various pathogens such as Gardnerella spp. (GS) and related anaerobic bacteria resulting bacterial vaginosis (BV). At present, treatment options for BV are extremely limited. Treatment antibacterial drugs acidification two primary therapeutic methods. Acid electrolyzed water (AEW) is known to inactivate microorganisms considered a medical...
Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases risk of cancer recurrence and distant metastasis. The properties lymph node (LNM-CRC) cells are poorly understood, effective therapies still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha (FAP
Abstract Comparison of the fluorescence intensity caused by accumulation Pp IX in endometrial cancer xenografts nude mice after low‐dose 5‐Aminolevulinic acid (ALA) injection combined with si RNA transfection was mediated ultrasound microbubbles and polyethyleneimine (PEI) to explore feasibility microbubble technique as agents. Knockdown ferrochelatase (FECH) human performed FECH ‐si PEI alone or combination; then, ALA injected. Subsequently, an vivo animal imaging system employed detect...
Abstract Background There is limited data on the effects of gender-affirming hormone therapy body fat changes in Chinese transwomen. It's unclear whether affects obesity and blood lipid levels this population.The purpose study was to evaluate treatment duration re-accumulation distribution Methods The included 40 transwomen who had not received 59 had. Body were measured. also stratified participants based assess its impact distribution. Results After receiving therapy, total increased by...