A5021521011- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Head and Neck Surgical Oncology
- Esophageal Cancer Research and Treatment
- Meningioma and schwannoma management
- Esophageal and GI Pathology
- Ear Surgery and Otitis Media
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Ear and Head Tumors
- Tracheal and airway disorders
- Gastrointestinal Tumor Research and Treatment
- Hearing Loss and Rehabilitation
- Neutropenia and Cancer Infections
- Hepatitis C virus research
- Gastrointestinal disorders and treatments
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Gallbladder and Bile Duct Disorders
- Cancer therapeutics and mechanisms
- Hematopoietic Stem Cell Transplantation
- Cerebrospinal fluid and hydrocephalus
- Nasal Surgery and Airway Studies
- Lung Cancer Diagnosis and Treatment
City Of Hope National Medical Center
2015-2024
City of Hope
2013-2024
University of Kansas
2013-2023
University of Kansas Medical Center
2013-2023
Yale University
2021
Rush University Medical Center
2006-2018
The University of Kansas Health System
2017
University Gastroenterology
2017
University of Missouri
2016
ENT and Allergy
2016
Nanoparticle-based therapeutics are being used to treat patients with solid tumors. Whereas nanoparticles have been shown preferentially accumulate in tumors of animal models, there is little evidence prove that intact localize humans when systemically administered. Here, tumor and adjacent, nonneoplastic tissue biopsies obtained through endoscopic capture from gastric, gastroesophageal, or esophageal cancer who administered the nanoparticle CRLX101. Both pre- postdosing samples adjacent...
Nanoparticles are currently being investigated in a number of human clinical trials. As information on how nanoparticles function humans is difficult to obtain, animal studies that can be correlative behavior needed provide guidance for Here, we report animals and CRLX101, 20- 30-nm-diameter, multifunctional, polymeric nanoparticle containing camptothecin (CPT). CRLX101 phase 2 trials, data from several the investigations compared with results multispecies studies. The pharmacokinetics...
Intraoperative frozen section analysis of surgical margins is widely used in head and neck cancer surgery. This study evaluates accuracy relative to permanent controls final from the entire specimen, rate at which sections impact intraoperative management, resultant cost.Retrospective.From 1997 1999 results, controls, tumor 80 consecutive patients undergoing 420 for malignancy were reviewed.A 98.3% (sensitivity, 88.8%; specificity, 98.9%) was found compared with same tissue. However, 40% (8...
Objective Our objective is to evaluate the safety in patients with cochlear implants (CIs) and auditory brainstem (ABI) undergoing 1.5 Tesla (T) magnetic resonance imaging (MRI). Secondly, we want raise awareness on CI MRI safety, advocate for continued improvement advancement minimize morbidity our patients. Methods Retrospective case series from 2006 2018 at a single tertiary academic center. Data was collected or MRI. Outcomes include demographic data, age time of MRI, characteristics,...
Evaluate long-term prevalence of tumor growth and need for further treatment in patients with a vestibular schwannoma treated conservative management.Retrospective chart review.Private neurotologic tertiary referral center.Vestibular undergoing management previously studied (N = 114). Mean time to last magnetic resonance imaging was 4.8 years follow-up 6.4 (maximum, 18.5 yr).Serial gadolinium-enhanced size measurement.Change maximum dimension 2 mm or higher (growth), treatment, audiologic...
Objectives To determine the utility of three-dimensional (3D) printed models in individualized petroclival tumor resection planning by measuring fidelity anatomical structures and comparing exposure afforded different approaches. Design Case series review literature. Setting Tertiary care center. Participants Three patients with lesions. Main Outcome Measures Subjective opinion access neuro-otologists neurosurgeons as well surface area exposure. Results Surgeons found 3D each patient's skull...
Cochlear implantation is now being performed in ears with residual hearing. Those implant recipients who keep hearing may benefit from improved pitch resolution through both electrical and acoustic Preservation of cochlear function after a challenging task for the surgeon. Current topics preservation research include electrode design surgical technique. To maintain hearing, surgeons strive to create cochleostomy place minimally traumatic fashion. In this study, we examine novel...
CRLX101 is an investigational nanoparticle-drug conjugate with a camptothecin payload. Preclinical evidence indicated preferential uptake in tumors, and tumor xenograft models demonstrate superiority of over irinotecan. A pilot trial was conducted at recommended phase 2 dosing (RP2D) using the bimonthly schedule to assess vs. adjacent normal tissue endoscopically accessible tumors chemotherapy-refractory gastroesophageal cancer. Results from biopsies were previously reported herein we...
Our primary aim was to determine the incidence of sigmoid venous thrombosis (SVT) and risks factors sequelae SVT following cerebellopontine angle tumor resection.Retrospective cohort study.Academic tertiary care hospital.Patients over 18 years age who underwent resection meningioma or vestibular schwannoma from January 2005 April 2016 had postoperative magnetic resonance imaging.Diagnostic.Incidence official radiology reports compared with retrospective imaging review by our institutional...
Significance: Colorectal cancer incidence has decreased largely due to detection and removal of polyps. Computer-aided diagnosis development may improve on polyp discrimination. Aim: To advance discrimination using currently available commercial colonoscopy systems, we developed a deep neural network (DNN) separating the color channels from images acquired under narrow-band imaging (NBI) white-light endoscopy (WLE). Approach: Images normal colon mucosa polyps colonoscopies were studied. Each...
Objective The types of otogenic cerebrospinal fluid (CSF) fistulae were previously classified into defects through, adjacent to, or distal to the otic capsule. This article presents cases three different spontaneous CSF and reviews pertinent literature. We examine management leaks with modern audiovestibular testing, imaging, surgical techniques. Design Case series review Setting Academic tertiary neurotologic referral practice. Participants Four patients identified through a retrospective...
Objectives: The topic of prescription opioid overuse remains a growing concern in the United States. Our objective is to provide insight into pain perception and use based on patient cohort undergoing common otologic neurotologic surgeries. Study Design: Prospective observational study with questionnaire. Setting: Single academic medical center. Subjects Methods: Adult patients procedures by two fellowship trained neurotologists between June November 2018 were included this study. During...
The liver plays a key role in fuel metabolism. It is well established that disease associated with an increased risk for diabetes mellitus. Hepatitis C virus infection has been known to increase the of diabetes. However, much less about hepatitis B (HBV) We examined association based on vaccination status HBV.In this cross-sectional study, we included adult subjects (≥20 y/o) HBV serology available from National Health and Nutrition Examination Survey 2005-2010. Diabetes was defined as or...
Objectives To describe the impact of resident involvement in tympanoplasty on operative time and surgical complication rates. Study Design Case series with chart review. Setting Tertiary medical center. Subjects Methods Current Procedural Terminology codes were used to identify patients 2011-2014 public use files American College Surgeons National Surgical Quality Improvement Program who underwent a or tympanomastoidectomy. Cases included if database indicated whether operating room was...
Objectives Lateral temporal bone resection (LTBR) has traditionally been performed en bloc in accordance with oncologic principles. Occasionally, this is not possible due to a low tegmen or lateralized vasculature. We sought determine if outcomes of piecemeal and LTBR are comparable. Study Design Retrospective review. Setting Two academic medical centers. Subjects Methods Multi‐institutional retrospective cohort study. Current Procedural Terminology codes were used identify patients T1 T3...
The aim of this study was to determine the negative predictive value positron emission tomography (PET)/computed (CT) in patients with lesions suggestive pancreatic cancer.A retrospective review from January 2005 August 2008 all who underwent a PET/CT evaluate lesion cancer based on prior imaging. One hundred eighty-four PET/CT, which 60 had PET scan. Of these patients, 56 (30 women, 26 men) endoscopic ultrasound-guided fine-needle aspiration or surgical pathology for clinical correlation....
Endoscopic management of superficial esophageal adenocarcinoma has gained wider acceptance with the growing literature on its efficacy. Patient selection is critical in deciding who should be a candidate for surgery or endoscopy T1 cancer. This article discusses key role EMR plays diagnostic evaluation.
Multiple investigators have sought to identify risk factors for cerebrospinal fluid (CSF) leak following cerebellopontine angle (CPA) tumor resection. We evaluated whether pneumatization of the petrous apex (PA) is a factor CSF fistula.We conducted retrospective chart review at 2 major tertiary academic institutions undergoing CPA resection and analyzed their respective head or temporal computed tomography (CT) scans if available.A total 91 cases were identified; 51 (64%) demonstrated PA...
Immune checkpoint inhibitors (ICIs) have shown promise in treating a variety of cancers. Their increased use coincides with incidence immunotherapy-mediated colitis (IMC), common adverse effect. Optimal strategy for endoscopic evaluation IMC (full colonoscopy or flexible sigmoidoscopy) is not well-defined.Retrospective review all patients at City Hope referred to gastroenterology due gastrointestinal symptoms was performed. Patients an existing histologic diagnosis established outside...