Philip Hart
A5069874443- Advanced X-ray Imaging Techniques
- Pancreatic and Hepatic Oncology Research
- Particle Detector Development and Performance
- Advanced Electron Microscopy Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Ethics in Clinical Research
- Pancreatitis Pathology and Treatment
- Medical Imaging Techniques and Applications
- Particle Accelerators and Free-Electron Lasers
- Laser-Plasma Interactions and Diagnostics
- Cancer Genomics and Diagnostics
- CCD and CMOS Imaging Sensors
- Advanced X-ray and CT Imaging
- Gastrointestinal disorders and treatments
- Advanced Causal Inference Techniques
- Advancements in Semiconductor Devices and Circuit Design
- Enzyme Structure and Function
- Advancements in Photolithography Techniques
- COVID-19 and healthcare impacts
- Radiation Detection and Scintillator Technologies
- Colorectal Cancer Screening and Detection
- IgG4-Related and Inflammatory Diseases
- Magnetic properties of thin films
- Crystallography and Radiation Phenomena
- High-pressure geophysics and materials
The Ohio State University Wexner Medical Center
2016-2025
SLAC National Accelerator Laboratory
2014-2025
Linac Coherent Light Source
2014-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2020
Menlo School
2014-2019
European X-Ray Free-Electron Laser
2017
Brookhaven National Laboratory
2017
Williams (United States)
2017
SRI International
2017
RELX Group (Netherlands)
2017
(Abridged) The Large Area Telescope (Fermi/LAT, hereafter LAT), the primary instrument on Fermi Gamma-ray Space (Fermi) mission, is an imaging, wide field-of-view, high-energy gamma-ray telescope, covering energy range from below 20 MeV to more than 300 GeV. This paper describes LAT, its pre-flight expected performance, and summarizes key science objectives that will be addressed. On-orbit performance presented in detail a subsequent paper. LAT pair-conversion telescope with precision...
Size Matters Less X-ray crystallography is a central research tool for uncovering the structures of proteins and other macromolecules. However, its applicability typically requires growth large crystals, in part because sufficient number molecules must be present lattice sample to withstand x-ray—induced damage. Boutet et al. (p. 362 , published online 31 May) now demonstrate that intense x-ray pulses emitted by free-electron laser source can yield data few enough exposures uncover...
Objectives To evaluate the efficacy of rituximab (RTX) in IgG4-related disease (IgG4-RD) an open-label pilot trial. Methods We treated 30 IgG4-RD patients with two doses RTX (1000 mg each). The participants were either alone (n = 26; 87%) or required to discontinue baseline glucocorticoids (GC) within 2 months 4; 13%). Disease activity was measured by Responder Index (IgG4-RD RI) and physician's global assessment (PGA). response defined as improvement RI points. primary outcome, at 6 months,...
The Vela pulsar is the brightest persistent source in GeV sky and thus traditional first target for new gamma-ray observatories. We report here on initial Fermi Large Area Telescope observations during verification phase pointed exposure early survey scanning. have used signal to verify timing angular resolution. high quality pulse profile, with some 32,400 pulsed photons at E>0.03 GeV, shows features, including structure as fine 0.3ms a distinct third peak, which shifts energy. examine...
The ultrabright femtosecond X-ray pulses provided by free-electron lasers open capabilities for studying the structure and dynamics of a wide variety systems beyond what is possible with synchrotron sources. Recently, this “probe-before-destroy” approach has been demonstrated atomic determination serial diffraction microcrystals. There question whether similar can be extended to probe local electronic spectroscopy. To address this, we have carried out emission spectroscopy (XES) at Linac...
The Linear Coherent Light Source (LCLS), a free electron laser operating from 250eV to10keV at 120Hz, is opening windows on new science in biology, chemistry, and solid state, atomic, plasma physics<sup>1,2</sup>. FEL provides coherent x-rays femtosecond pulses of unprecedented intensity. This allows the study materials up to 3 orders magnitude shorter time scales than previously possible. Many experiments LCLS require detector that can image scattered per-shot basis with high efficiency...
Free-electron lasers (FELs) present new challenges for camera development compared with conventional light sources. At SLAC a variety of technologies are being used to match the demands Linac Coherent Light Source (LCLS) and support wide range scientific applications. In this paper an overview X-ray detector design requirements at FELs is presented various cameras in use described benefit users planning experiments or analysts looking data. Features operation CSPAD camera, which currently...
Abstract The dynamics of liquid water feature a variety time scales, ranging from extremely fast ballistic-like thermal motion, to slower molecular diffusion and hydrogen-bond rearrangements. Here, we utilize coherent X-ray pulses investigate the sub-100 fs equilibrium ambient conditions down supercooled temperatures. This novel approach utilizes inherent capability speckle visibility spectroscopy measure intermolecular with lengthscale selectivity, by measuring oxygen motion in momentum...
The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers. Despite encouraging results on large particles, small particles has proven to be difficult two reasons: not quite high enough pulse intensity from currently available lasers and, as we demonstrate here, contamination the aerosolized molecules by nonvolatile contaminants in solution. amount sample depends initial droplet size during aerosolization. Here, show that, with our electrospray injector,...
Abstract Single-particle diffraction from X-ray Free Electron Lasers offers the potential for molecular structure determination without need crystallization. In an effort to further develop technique, we present a dataset of coherent soft images Coliphage PR772 virus, collected at Atomic Molecular Optics (AMO) beamline with pnCCD detectors in LAMP instrument Linac Coherent Light Source. The diameter ranges 65–70 nm, which is considerably smaller than previously reported ~600 nm Mimivirus....
The last decade has shown the great potential that X-ray Free Electron Lasers (FEL) have to study High Energy Density (HED) physics. Experiments at FELs made significant breakthroughs in Shock Physics and Dynamic Diffraction, Dense Plasma Warm Matter Science, using techniques such as isochoric heating, inelastic scattering, small angle scattering diffraction. In addition, complementary these techniques, coherent properties of FEL beam can be used image HED samples with high fidelity. We...
X-ray magnetic circular dichroism spectroscopy using an free electron laser is demonstrated with spectra over the Fe L3,2-edges. The high brightness of combined accuracy detection incident and transmitted X-rays enables ultrafast studies unprecedented sensitivity. This new capability applied to a study all-optical switching dynamics Gd sublattices in GdFeCo thin film above its magnetization compensation temperature.
Inertial confinement fusion (ICF) holds increasing promise as a potential source of abundant, clean energy, but has been impeded by defects such micro-voids in the ablator layer fuel capsules. It is critical to understand how these interact with laser-driven shock waves that compress pellet. At Matter Extreme Conditions (MEC) instrument at Linac Coherent Light Source (LCLS), we utilized an x-ray pulse train ns separation, microscope, and ultrafast imaging (UXI) detector image wave...
X-ray detection at free-electron lasers is challenging in part due to the XFEL's extremely short and intense pulses. Experimental measurements are further complicated by large fluctuations inherent self-amplified spontaneous emission process producing X-rays. At Linac Coherent Light Source ePix10ka2M detector offers multiple gain modes, auto-ranging between these, increase dynamic range while retaining low noise. For diffuse scattering techniques, such as time-resolved solution scattering,...
In this work, we describe the instrumentation used to perform first operando transmission X-ray microscopy (TXM) and simultaneous diffraction of laser melting simulating powder bed fusion on XCS instrument at Linac Coherent Light Source (LCLS) free-electron (XFEL). Our TXM with 40× magnification in regime 11 keV gave spatial resolutions down 940 nm per line pair, effective pixel sizes 206 nm, image integration times <100 fs, frame rates tunable between 2.1 119 ns for two probe frames (0.48...
The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is seventh and newest world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, employing ultrafast pulses of X-rays from LCLS atmospheric conditions to overcome radiation damage limitations in biological measurements. also capable performing various time-resolved MFX design consists versatile base system supporting multiple methods,...
The ePix10ka2M (ePix10k) is a new large area detector specifically developed for X-ray free-electron laser (XFEL) applications. hybrid pixel was at SLAC to provide hard with high dynamic range, running the 120 Hz repetition rate of Linac Coherent Light Source (LCLS). ePix10k consists 16 modules, each 352 × 384 pixels 100 µm distributed on four ASICs, resulting in 2.16 megapixel detector, 16.5 cm active and ∼80% coverage. range achieved three distinct gain settings (low, medium, high) as well...
Abstract Since its inception two years ago, the international, multicenter Pancreatic Cancer Early Detection (PRECEDE) Consortium has enrolled high-risk individuals (HRI) undergoing pancreatic ductal adenocarcinoma (PDAC) surveillance. Herein we aim to evaluate enrollment disparities in PRECEDE. Data on HRIs between May 2020 and March 2022 were collected, with defined as participants PRECEDE meeting guideline-based criteria for PDAC Of 1,273 enrolled, 1,113 eligible inclusion, 47.2% familial...
The Cornell-SLAC pixel array detector (CSpad) is a general-purpose integrating hybrid x-ray camera developed for use at the Linear Coherent Light Source (LCLS) free electron laser SLAC National Accelerator Laboratory (SLAC). has full well capacity of about 2.Sk photons in low-gain mode and SIN 6 high-gain mode. Its 2.3M pixels are read out 120 Hz. comprises 32 500μm silicon sensors bump-bonded to 64 185×194-pixel ASICs. size 110μm. water-cooled quadrants can be radially moved in-situ vary...
ePix is a novel class of ASIC architectures, based on common platform, optimized to build modular scalable detectors for LCLS. The platform architecture composed random access analog matrix pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog-to-digital converters per column. It also implements control interface all the required support electronics perform configuration, calibration readout matrix. Based this front-end ASICs several camera modules,...