A5100447864- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Tryptophan and brain disorders
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Neuroscience and Music Perception
- Adipokines, Inflammation, and Metabolic Diseases
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Neuroscience and Neural Engineering
- Wound Healing and Treatments
- Hearing Loss and Rehabilitation
- Genetic Neurodegenerative Diseases
Peking University
2017-2023
Ningxia Medical University
2023
First Affiliated Hospital of Wannan Medical College
2022-2023
Center for Life Sciences
2023
Chinese Institute for Brain Research
2022-2023
Chongqing Medical University
2023
First Affiliated Hospital Zhejiang University
2021-2022
National Institute of Biological Sciences, Beijing
2020-2022
Zhejiang University
2021-2022
Wannan Medical College
2022
Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury (SCI) by bridging cavity spaces. However, there are limited reports of injectable, electroconductive hydrogels with self-healing properties being employed for the SCI. Hence, natural extracellular matrix (ECM) biopolymer (chondroitin sulphate and gelatin)-based hydrogel containing polypyrrole, which imparted properties, developed SCI repair. The resulting showed...
Conductive scaffolds have been shown to exert a therapeutic effect on patients suffering from peripheral nerve injuries (PNIs). However, conventional conductive conduits are made of rigid structures and limited applications for impaired diabetic due their mechanical mismatch with neural tissues poor plasticity. We propose the development biocompatible electroconductive hydrogels (ECHs) that identical surgical dressing in this study. Based excellent adhesive self-healing properties, thin...
Abstract Treating peripheral nerve defects represents a clinical challenge, and conduits lacking an internal scaffold lead to limited large gap regeneration. Here, we bridged 10‐mm sciatic in rats with chitosan conduit filled 0, 0.5, or 1.0 mg of simvastatin Pluronic F‐127 hydrogel. We assessed subsequent regeneration using the functional index (SFI), electrophysiological assessments, Fluoro‐Gold (FG) retrograde tracing, gastrocnemius muscle mass measurements, histological...
Adipose tissue remodeling plays a significant role in obesity-induced insulin resistance. Published studies reported that level of trigger receptor expressed on myeloid cells 2 (TREM2) adipose is up-regulated animal models obesity. This study aims to investigate whether TREM2 regulates resistance via modulating mice high-fat diet (HFD).Wild-type (WT) and TREM2-/- were both fed with controlled-fat (CFD) or HFD for 12 weeks studied obesity Meanwhile, epididymal (EAT) was examined morphological...
Recovery from spinal cord injuries after transplanted neural stem cells encapsulated in chondroitin sulfate methacrylate hydrogels.
Abstract Background A few studies have been conducted on the relationship between cerebellar volume and emotional memory or clinical severity in major depressive disorder (MDD). In this study, we aimed to compare density of gray matter (GM) patients with MDD healthy controls (HCs) explore association these parameters measurements severity. Method Voxel‐based morphometry (VBM) Individual Brain Atlases using Statistical Parametric Mapping (IBASPM) were used assess GM cerebellum, respectively,...
Abstract The neural mechanisms of fear-associated thermoregulation remain unclear. Innate fear odor 2-methyl-2-thiazoline (2MT) elicits rapid hypothermia and elevated tail temperature, indicative vasodilation-induced heat dissipation, in wild-type mice, but not mice lacking Trpa1–the chemosensor for 2MT. Here we report that Trpa1 −/− show diminished 2MT-evoked c-fos expression the posterior subthalamic nucleus (PSTh), external lateral parabrachial subnucleus (PBel) solitary tract (NTS)....
Abstract As a central part of the mammalian brain, prefrontal cortex (PFC) has been implicated in regulating cocaine-induced behaviors including compulsive seeking and reinstatement. Although dysfunction PFC reported animal human users with chronic cocaine abuse, less is known about how involved behaviors. By using two-photon Ca 2+ imaging to simultaneously record tens intact individual networking neurons frontal association (FrA) awake male mice, here we report that systematic acute...
The issue of whether human perception speech and song recruits integrated or dissociated neural systems is contentious. This difficult to address directly since these stimulus classes differ in their physical attributes. We therefore used a compelling illusion (Deutsch et al. 2011) which acoustically identical auditory stimuli are perceived as either song. Deutsch's was functional MRI experiment provide direct, within-subject investigation the brain regions involved perceptual transformation...
Abstract Histamine (HA) is a key biogenic monoamine involved in wide range of physiological and pathological processes both the central nervous system periphery. Because ability to directly measure extracellular HA real-time will provide important insights into functional role complex circuits under variety conditions, we developed series genetically encoded G protein-coupled r eceptor ctivation- b ased (GRAB) (GRAB ) sensors. These sensors produce robust increase fluorescence upon...
The original
Neuropathic pain (Np) is a chronic disease without effective treatment options. Accumulating evidence has revealed that autophagy dysfunction plays significant role during the pathogenesis and etiology of Np. Trigger receptor expressed on myeloid cells 2 (TREM2), which mainly such as macrophages, microglia monocyte-derived dendritic cells, was recently reported to be closely associated with microglial in animal models neurodegenerative diseases. This study aims investigate whether TREM2...
Abstract Mammals normally maintain a constant body temperature irrespective of their environmental temperature. However, emotions such as fear can trigger acute changes in accompanying defensive behaviors to enhance survival life-threatening conditions. The neural mechanisms fear-associated thermoregulation remain unclear. Here, we find that innate odor 2-methyl-2-thiazoline (2MT) evokes rapid hypothermia and elevated tail temperature, indicative vasodilation-induced heat dissipation,...
Prolonged sevoflurane exposure leads to neurotoxicity. Autophagy plays an important role in promoting cell survival different conditions. However, the and mechanism of autophagy sevoflurane-induced neurotoxicity were not fully elucidated. We attempted indicate whether could activate AMP-activated protein kinase (AMPK)/mechanistic target rapamycin (mTOR)-mediated attenuate anesthetics-induced neuronal injury this study. Sevoflurane treatment significantly decreased viability induced apoptosis...