A5076613679- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Tactile and Sensory Interactions
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Surgical Sutures and Adhesives
- Spinal Cord Injury Research
- Graphene and Nanomaterials Applications
- 3D Printing in Biomedical Research
- Planarian Biology and Electrostimulation
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Cervical and Thoracic Myelopathy
- Dielectric materials and actuators
- Spine and Intervertebral Disc Pathology
- Extracellular vesicles in disease
- Supercapacitor Materials and Fabrication
- Osteoarthritis Treatment and Mechanisms
- MXene and MAX Phase Materials
Huazhong University of Science and Technology
2023-2024
Guangdong University of Technology
2022-2024
Piezoelectric hydrogel sensors are becoming increasingly popular for wearable sensing applications due to their high sensitivity, self-powered performance, and simple preparation process. However, conventional piezoelectric hydrogels lack antifreezing properties thus confronted with the liability of rupture in low temperatures owing use water as dispersion medium. Herein, a kind organohydrogel that integrates piezoelectricity, low-temperature tolerance, mechanical robustness, stable...
Abstract Photothermal hydrogel adhesives have yielded promising results for wound closure and infected treatment in recent years. However, photothermal bioadhesives with on‐demand removability without additional nanomaterials‐based agents rarely been reported the literature. In this work, an injectable intrinsic bioadhesive removal trait is developed through dynamic cross‐linking of gelatin (Gel), tannic acid (TA) quinone, borax closing skin incisions accelerating methicillin‐resistant...
Abstract Electroconductive hydrogels offer a promising avenue for enhancing the repair efficacy of spinal cord injuries (SCI) by restoring disrupted electrical signals along cord’s conduction pathway. Nonetheless, application composed diverse electroconductive materials has demonstrated limited capacity to mitigate post-SCI inflammatory response. Recent research indicated that transplantation M2 microglia effectively fosters SCI recovery attenuating excessive Exosomes (Exos), small vesicles...
Characterized by nucleus pulposus (NP) cell senescence and extracellular matrix (ECM) degradation, disc degeneration is a common pathology for various degenerative spinal disorders. To date, effective treatments are absent. Here, we found that Glutaredoxin3 (GLRX3) an important redox-regulating molecule associated with NP degeneration. Using hypoxic preconditioning method, developed GLRX3+ mesenchymal stem cell-derived vehicles (EVs-GLRX3), which enhanced the cellular antioxidant defense,...
Preventing local tumor recurrence and simultaneously improving bone-tissue regeneration are in great demand for osteosarcoma therapy. However, the current therapeutic implants fail to selectively suppress growth enhance osteogenesis, antitumor therapy may compromise osseointegration of bone implant. Here, based on different responses cells osteoblasts electric stimulations, we constructed ferroelectric BaTiO3 nanorod arrays (NBTO) surface titanium with switchable dynamic static electrical...
Abstract Successful regeneration of the peripheral nerve relies on collaborative efforts neural cells and immune cells. Conductive hydrogels have yielded promising results in supporting axonal growth; however, their inability to regulate response poor biological integration with tissues hinder repair injured nerves. Herein, an adhesive conductive immunomodulatory hydrogel bandage is developed for regeneration. The prepared from bioactive material extracellular matrix (ECM), oxidized...
Bioadhesives are widely used in a variety of medical settings due to their ease use and efficient wound closure repair. However, achieving both strong adhesion removability/reusability is highly needed but challenging. Here, we reported an injectable mesoporous bioactive glass nanoparticle (MBGN)-incorporated biopolymer hydrogel bioadhesive that demonstrates strength (up 107.55 kPa) at physiological temperatures also removable reusable. The incorporation MBGNs the significantly enhances...
Piezoelectric sensors are widely used in wearable devices to mimic the functions of human skin. However, it is considerably challenging develop soft piezoelectric materials that can exhibit high sensitivity, stretchability, super elasticity, and suitable modulus. In this study, a skin-like polymer elastomer composed poly(vinylidene fluoride) (PVDF) novel elastic substrate polyacrylonitrile prepared by combining radical polymerization freeze-drying processes. Dipole-dipole interaction results...
Recent breakthroughs in cell transplantation therapy have revealed the promising potential of bone marrow mesenchymal stem cells (BMSCs) for promoting regeneration growth plate cartilage injury. However, high apoptosis rate and uncertainty differentiation direction often lead to poor therapeutic effects. Cells are grown under three-dimensional (3D) conditions vivo, stiffness components extracellular matrix (ECM) important regulators differentiation. To this end, a 3D cartilage-like ECM...
Conductive hydrogels possessing conductivity, flexibility, and biocompatibility have garnered considerable attention in recent years for their applications flexible wearable devices. However, most reported conductive are mainly elastic hydrogel substrates with chemically cross-linked networks, poor shape adaptability, irreversible electromechanical properties after molding, thereby limiting prospective utility electronics. In this study, we fabricate multifunctional...
All-polymer piezoelectric elastomers that integrate self-powered, soft, and elastic performance are attractive in the fields of flexible wearable electronics human–machine interfaces. However, a lack adhesion UV-blocking performances greatly hinders potential applications these emerging fields. Here, high-performance elastomer with piezoelectricity, mechanical robustness, self-adhesion, UV-resistance was developed by using poly(vinylidene fluoride) (PVDF), acrylonitrile (AN), acrylamide...
Flexible and piezoelectric hydrogels show great potential in the fields of wearable sensors, soft robotics, human–machine interface. However, these existing hydrogel sensors lack adhesive properties to skin, limiting their further application. Here, by introducing methacryloxyethyltrimethylammonium chloride (DMC) sodium p-styrenesulfonate (NaSS) into polyacrylonitrile (PAN) hydrogel, a polyelectrolyte (PNxDyAz) was prepared through electrostatic interaction between polyelectrolytes. The...
水凝胶传感器已成功在生物学和电子产品之间实现了无缝结合，但这些材料经常受到机械性能差、需要外部电源或电池等问题的困扰. 本文以聚乙烯醇(PVA)、丙烯腈(AN)、对苯乙烯磺酸钠(NaSS)、丙烯酰胺(AAm)为原料，N，N-亚甲基双丙烯酰胺(MBA)为交联剂制备了一种基于聚丙烯腈的自发电水凝胶(PVA-PAN). 通过红外光谱、力学性能测试、力电响应性能测试对其进行性能表征，研究结果表明PAN链间的偶极相互作用和PVA与PAN链段间的氢键作用促进PAN向平面之字型构象转移，水凝胶的最大压电系数d33为32 p/CN，具有与皮肤相类似的杨氏模量值(0.08 ~ 5.49 MPa)和良好的延展性(97~408%). 由于应力诱导的极化效应，该自发电水凝胶能够产生约60 mV的电信号输出. 通过V-T曲线表明该水凝胶可以通过电压信号的变化精确地检测人体的各种活动(如关节的运动、步频等). 本研究制备的自发电水凝胶传感器具有易制备、低成本、高弹性、自发电等优点，为其应用在人造皮肤、人体健康检测以及医疗诊断等领域提供一定理论指导依据.