Changhao Li

ORCID: 0000-0003-1301-501X
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About
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Research Areas
  • Advancements in Battery Materials
  • Dielectric materials and actuators
  • Vibration Control and Rheological Fluids
  • Advanced Sensor and Energy Harvesting Materials
  • Advanced Battery Materials and Technologies
  • Bone Tissue Engineering Materials
  • Micro and Nano Robotics
  • Planarian Biology and Electrostimulation
  • Cellular Mechanics and Interactions
  • Estrogen and related hormone effects
  • Advanced Battery Technologies Research
  • 3D Printing in Biomedical Research
  • Thin-Film Transistor Technologies
  • Modular Robots and Swarm Intelligence
  • Seismic Performance and Analysis
  • Bacterial biofilms and quorum sensing
  • Advanced Photocatalysis Techniques
  • Nanoplatforms for cancer theranostics
  • Recycling and Waste Management Techniques
  • Diamond and Carbon-based Materials Research
  • Ferrocene Chemistry and Applications
  • Extraction and Separation Processes
  • ATP Synthase and ATPases Research
  • Covalent Organic Framework Applications
  • Catalytic Processes in Materials Science

Wuhan University of Technology
2024-2025

Guangxi University
2023-2025

Shandong Agricultural University
2025

Nanjing University of Science and Technology
2021-2025

North China University of Technology
2024

Stomatology Hospital
2023-2024

Sun Yat-sen University
2023-2024

Pennsylvania State University
2020-2024

University of International Business and Economics
2024

Soochow University
2024

Polymer composites with electrically conductive fillers have been developed as mechanically flexible, easily processable electromagnetic interference (EMI) shielding materials. Although there are a few elastomeric nanostructured silvers and carbon nanotubes showing moderate stretchability, their EMI effectiveness (SE) deteriorates consistently stretching. Here, highly stretchable polymer composite embedded three-dimensional (3D) liquid-metal (LM) network exhibiting substantial increases of...

10.1002/adma.201907499 article EN Advanced Materials 2020-02-20

The treatment of critical-size bone defects with irregular shapes remains a major challenge in the field orthopedics. Bone implants adaptability to complex morphological defects, bone-adhesive properties, and potent osteogenic capacity are necessary. Here, shape-adaptive, highly bone-adhesive, ultrasound-powered injectable nanocomposite hydrogel is developed via dynamic covalent crosslinking amine-modified piezoelectric nanoparticles biopolymer networks for electrically accelerated healing....

10.1186/s12951-024-02320-y article EN cc-by Journal of Nanobiotechnology 2024-02-07

Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment. However, the therapeutic efficacy of traditional photosensitizers limited, and they lack ability to regenerate bone. Here, a piezo-photo nanoheterostructure developed based on ultrasmall bismuth/strontium titanate nanocubes (denoted as Bi/SrTiO3), which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance efficiently generate...

10.1016/j.bioactmat.2024.01.003 article EN cc-by-nc-nd Bioactive Materials 2024-01-06

A strategy to develop chemotherapeutic agents by combining several active groups into a single molecule as conjugate that can modulate multiple cellular pathways may produce compounds having higher efficacy compared of single-target drugs. In this article, we describe the synthesis and evaluation an array dual-acting ER histone deacetylase inhibitors. These novel hybrid combine indirect antagonism structure motif (OBHS, oxabicycloheptene sulfonate) with HDAC inhibitor suberoylanilide...

10.1021/acs.jmedchem.5b00099 article EN Journal of Medicinal Chemistry 2015-05-20

Abstract In growing active matter systems, a large collection of engineered or living autonomous units metabolize free energy and create order at different length scales as they proliferate migrate collectively. One such example is bacterial biofilms, surface-attached aggregates cells embedded in an extracellular matrix that can exhibit community-scale orientational order. However, how growth coordinates with cell-surface interactions to distinctive, long-range during biofilm development...

10.1038/s41467-021-26869-6 article EN cc-by Nature Communications 2021-11-17

Although excellent dielectric, piezoelectric, and pyroelectric properties matched with or even surpassing those of ferroelectric ceramics have been recently discovered in molecular ferroelectrics, their successful applications devices are scarce. The fracture proneness ferroelectrics under mechanical loading precludes as flexible sensors bulk crystalline form. Here, self-powered prepared from the facile deposition [C(NH2 )3 ]ClO4 onto a porous polyurethane (PU) matrix reported. -PU is...

10.1002/adma.202104107 article EN Advanced Materials 2021-09-12

Pathological angiogenesis frequently occurs in tumor tissue, limiting the efficiency of chemotherapeutic drug delivery and accelerating progression. However, traditional vascular normalization strategies are not fully effective limited by development resistance. Herein, inspired intervention endogenous bioelectricity vessel formation, we propose a wireless electrical stimulation therapeutic strategy, capable breaking bioelectric homeostasis within cells, to achieve normalization. Polarized...

10.1016/j.bioactmat.2022.03.027 article EN cc-by-nc-nd Bioactive Materials 2022-03-28

It is attractive to fabricate molds and dies using additive manufacturing (AM) technology because the increased freedom of design makes higher cooling efficiency possible. However, little known so far about thermal properties tool steels fabricated by AM, as well how balance between mechanical properties. In this work, an H13 steel was processed selective laser melting (SLM) followed heat treatments in relation microstructure were investigated. The as-built showed lower conductivities...

10.1016/j.matdes.2022.111295 article EN cc-by-nc-nd Materials & Design 2022-10-22

We investigate whether large language models can perform the creative hypothesis generation that human researchers regularly do. While error rate is high, generative AI seems to be able effectively structure vast amounts of scientific knowledge and provide interesting testable hypotheses. The future enterprise may include synergistic efforts with a swarm "hypothesis machines", challenged by automated experimentation adversarial peer reviews.

10.1016/j.jmat.2023.08.007 article EN cc-by Journal of Materiomics 2023-09-18

Low concentration NaHCO3 (ca. 12 mM) had been demonstrated to be an excellent carbon source for industrially important green alga Chlorella vulgaris and high (e.g. 160 shown capable of controlling protozoa stimulating lipid accumulation another alga, i.e., Neochloris oleoabundans. Furthermore, little was known about the mechanisms effects on microalgae. Thorough studies C. their were therefore warranted.We systematically compared cell growth, production, morphology in mM or NaCl media at...

10.1186/s12934-018-0953-4 article EN cc-by Microbial Cell Factories 2018-07-09

Abstract Insufficient angiogenesis frequently occurs after the implantation of orthopedic materials, which greatly increases risk bone defect reconstruction failure. Therefore, development implant with improved angiogenic properties is great importance. Mimicking extracellular matrix clues provides a more direct and effective strategy to modulate angiogenesis. Herein, inspired by bioelectrical characteristics microenvironment, piezoelectric bioactive glasses composite (P‐KNN/BG) based on...

10.1002/adhm.202300064 article EN Advanced Healthcare Materials 2023-02-28

Abstract Mimicking the natural bone extracellular matrix containing intrinsic topography and electrical signals is an effective way to modulate regeneration. However, simultaneously coupling of mechanobiology cues implant regeneration remains ignored. Here, authors report in situ designation titanium dioxide (TiO 2 ) nanocone/bismuth oxide (Bi O 3 nanodot heterojunctions on surface electro‐biomechanically trigger osseointegration at bone/implant interface. TiO nanocone/Bi exhibit built‐in...

10.1002/adfm.202106249 article EN Advanced Functional Materials 2021-09-12

Preventing local tumor recurrence and simultaneously improving bone-tissue regeneration are in great demand for osteosarcoma therapy. However, the current therapeutic implants fail to selectively suppress growth enhance osteogenesis, antitumor therapy may compromise osseointegration of bone implant. Here, based on different responses cells osteoblasts electric stimulations, we constructed ferroelectric BaTiO3 nanorod arrays (NBTO) surface titanium with switchable dynamic static electrical...

10.1021/acsnano.2c07900 article EN ACS Nano 2022-11-22
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