A5075490817- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Sarcoma Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- Luminescence and Fluorescent Materials
- Electrospun Nanofibers in Biomedical Applications
- Titanium Alloys Microstructure and Properties
- Polymer Surface Interaction Studies
- RNA modifications and cancer
- MXene and MAX Phase Materials
- Orthopaedic implants and arthroplasty
- Molecular Sensors and Ion Detection
- Tissue Engineering and Regenerative Medicine
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Advanced Nanomaterials in Catalysis
- Mesenchymal stem cell research
- Metal and Thin Film Mechanics
- Cellular Mechanics and Interactions
- Inflammation biomarkers and pathways
- Intermetallics and Advanced Alloy Properties
- Silk-based biomaterials and applications
Beijing Jishuitan Hospital
2021-2025
Peking University
2021-2025
Capital Medical University
2023-2025
Weatherford College
2024
Beijing University of Chemical Technology
2014-2022
Abstract Photodynamic therapy (PDT) has long been shown to be a powerful therapeutic modality for cancer. However, PDT is undiversified and become stereotyped in recent years. Exploration of distinctive methods thus highly demand but remains severe challenge. Herein, an unprecedented 1+1+1>3 synergistic strategy proposed validated the first time. Three homologous luminogens with aggregation‐induced emission (AIE) characteristics were rationally designed based on simple backbone. Through...
Preventing local tumor recurrence while promoting bone tissue regeneration is an urgent need for osteosarcoma treatment. However, the therapeutic efficacy of traditional photosensitizers limited, and they lack ability to regenerate bone. Here, a piezo-photo nanoheterostructure developed based on ultrasmall bismuth/strontium titanate nanocubes (denoted as Bi/SrTiO3), which achieve piezoelectric field-driven fast charge separation coupling with surface plasmon resonance efficiently generate...
Nucleic acid (NA)-based therapy is proposed to address serious diseases such as cardiovascular (CVDs). Powerful NA delivery vehicles are essential for effective gene therapy. Herein, a novel type of vehicle, an unlockable core-shell nanocomplex (Hep@PGEA) with self-accelerating release, structurally designed. Hep@PGEA composed disulfide-bridged heparin nanoparticle (HepNP) core and low-toxicity PGEA cationic shell. In comparison NA, heparin, negatively charged polysaccharide macromolecule,...
Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit metastasis. Bioactive nanoparticles such as zinc oxide (ZnO NPs) growth, however, effect and mechanisms of them on tumor are still not clear. In this study, we firstly prepared well-dispersed ZnO NPs proved metastasis-related malignant behaviors including migration, invasion,...
Spindly cellulose nanocrystals were coated with Au nanoparticle-conjugated heterogeneous polymer brushes prepared <italic>via</italic> different controllable polymerization.
Thoracic aortic dissection (TAD) is an aggressive vascular disease that requires early diagnosis and effective treatment. However, due to the particular structure narrowness of lesion location, there are no drug delivery systems for therapy TAD. Here, we report a multifunctional nanosystem (TP-Gd/miRNA-ColIV) composed gadolinium-chelated tannic acid (TA), low-toxic cationic PGEA (ethanolamine-aminated poly(glycidyl methacrylate)) type IV collagen targeted peptide (ColIV) nucleic therapy,...
Metal complexes that exhibit both near-infrared (NIR) phosphorescence imaging and chemotherapeutic activity would represent a novel class of anticancer drugs in clinical tumor treatment. In this work, series rodlike nanomicelles have been fabricated water by coupling poly(ethylene oxide)-block-poly(sodium acrylate) [Rh(C≡N-2,6-xylyl)4]+(1/2SO4)−. These intense NIR excellent stability. As revealed vivo data, the nanomicelle can selectively stain sites with long retention time. Moreover,...
Overactive inflammatory cascade accompanied by oxidative stress in the nucleus pulposus exacerbates intervertebral disc degeneration (IVDD). Hydrogels have been demonstrated to be promising treating IVDD, yet they remain less efficacious case of anti-inflammation associated with antioxidation. In this study, we designed an injectable self-antioxidant hydrogel (HA/CS) enhanced inflammation inhibitory performance for delivering chondroitin sulfate (CS) well-documented anti-inflammatory...
Due to its good properties such as low cytotoxicity, degradability, and biocompatibility, poly(aspartic acid) (PAsp) is a candidate for the development of new drug delivery systems. In this work, series PAsp-based degradable supramolecular assemblies were prepared effective gene therapy via host–guest interactions between cyclodextrin (CD)-cored polycations pendant benzene group-containing PAsp backbones. Such exhibited enhanced pDNA condensation ability, cytotoxicity. More importantly,...
Implant-associated infections are urgently addressed; however, existing materials difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfering with proton and electron transfer the bacterial membrane. As a proof-of-principle demonstration, special Schottky heterojunction film composed gold alkaline magnesium-iron mixed metal oxides (Au/MgFe-MMO) was constructed titanium implant. Once contacted...
Polysaccharide-based copolymers have attracted much attention due to their effective performances. Heparin, as a kind of polysaccharide with high negative charge densities, has in biomedical fields. In this work, we report flexible way adjust the solubility heparin from water oil via introduction tetrabutylammonium groups for further functionalization. A range heparin-based comb poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMEMA), poly(dimethylaminoethyl (PDMAEMA), or...
Abstract Microenvironment‐responsive supramolecular assemblies have attracted great interest in the biomedical field due to their potential applications controlled drug release. In this study, oxidation‐responsive polycationic named CPAs are prepared for nucleic acid delivery via host–guest interaction of β‐cyclodextrin based polycations and a ferrocene‐functionalized zinc tetraaminophthalocyanine core. The reactive oxygen species (ROS) can accelerate disassembly CPA/pDNA complexes, which...
Abstract Photodynamic therapy (PDT) has long been shown to be a powerful therapeutic modality for cancer. However, PDT is undiversified and become stereotyped in recent years. Exploration of distinctive methods thus highly demand but remains severe challenge. Herein, an unprecedented 1+1+1>3 synergistic strategy proposed validated the first time. Three homologous luminogens with aggregation‐induced emission (AIE) characteristics were rationally designed based on simple backbone. Through...
Protein-based therapies are potential treatments for cancer, immunological, and cardiovascular diseases. However, effective delivery systems needed because of their instability, immunogenicity, so on. Crosslinked negatively charged heparin polysaccharide nanoparticle (HepNP) is proposed protein delivery. HepNP can efficiently condense vascular endothelial growth factor (VEGF) the unique electronegative sulfonic acid carboxyl domain heparin. then assembled with VEGF-C (Hep@VEGF-C) or VEGF-A...
To date, few effective treatments have been licensed for nonalcoholic fatty liver disease (NAFLD), which a kind of chronic disease. Mammalian sterile 20-like kinase 1 (MST1) is reported to be involved in the development NAFLD. Thus, we evaluated suitability redox-unlockable polymeric nanoparticle Hep@PGEA vector deliver MST1 or siMST1 (HCP/MST1 HCP/siMST1) NAFLD therapy. The can efficiently condensed functional nucleic acids into NAFLD-affected mouse upregulate downregulate expression....