A5004913608- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Silk-based biomaterials and applications
- MicroRNA in disease regulation
- Cervical and Thoracic Myelopathy
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Magnesium Alloys: Properties and Applications
- Autophagy in Disease and Therapy
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Aluminum Alloys Composites Properties
- Oral and Maxillofacial Pathology
- Endometriosis Research and Treatment
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Heterotopic Ossification and Related Conditions
- Cancer, Hypoxia, and Metabolism
- Molecular Biology Techniques and Applications
- Periodontal Regeneration and Treatments
- Case Reports on Hematomas
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Beijing Institute of Technology
2025
Fourth Affiliated Hospital of Guangxi Medical University
2025
Beijing Chao-Yang Hospital
2022-2024
Capital Medical University
2022-2024
Peking University Third Hospital
2017-2024
Peking University
2017-2024
Yang Hospital
2023
Weatherford College
2023
Beijing Anzhen Hospital
2023
Southern Medical University
2015-2016
Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit metastasis. Bioactive nanoparticles such as zinc oxide (ZnO NPs) growth, however, effect and mechanisms of them on tumor are still not clear. In this study, we firstly prepared well-dispersed ZnO NPs proved metastasis-related malignant behaviors including migration, invasion,...
Most of the magnesium (Mg) alloys possess excellent biocompatibility, mechanical properties and biodegradability in orthopedic applications. Addition Zn to further significantly improves their antibacterial properties.
Abstract In clinical practice, tumor recurrence and metastasis after orthopedic prosthesis implantation is an intensely troublesome matter. Therefore, to develop implant materials with antitumor property extremely necessary meaningful. Magnesium (Mg) alloys possess superb biocompatibility, mechanical biodegradability in applications. However, whether they had seldom been reported. recent years, it showed that zinc (Zn) not only promote the osteogenic activity but also exhibit good property....
Killing osteosarcoma cells by zinc oxide nanoparticles (NPs) and its underlying subcellular mechanism are never studied. Here, it is found that the NPs induce cross talk between apoptosis autophagy, which leads to cell death. Specifically, NP uptake promotes autophagy inducing accumulation of autophagosomes along with impairment lysosomal functions. The further causes uptaken release ions promoting their dissolution. These intracellular ions, together those originally released from...
Although ZnO nanoparticles (NPs) can kill human osteosarcoma cells, the underlying upstream regulatory mechanisms remain unclear. Since hypoxia inducible factor-1α (HIF-1α) regulates tumor microenvironment, here we explored interplay between HIF-1α regulation and mitophagy in NP-induced inhibition both vivo vitro. We found that NPs upregulated protein levels when they killed four common cell lines. This finding was consistent with our observations additional upregulation by a inducer CoCl2...
Sensors for detecting the presence, concentration or flow rate of target molecules are widely used in gas detection, environmental monitoring and industrial process control. Given increasing importance CO2 carbon capture, utilization, storage (CCUS) technologies various processes, this study explores micro power generation sensing potential adsorption-desorption processes. We delve into micro-mechanisms underlying temperature response NaX molecular sieve during these Using Monte Carlo...
The tumor-stroma ratio (TSR) has been regarded as an important factor associated with tumor metastasis, based on the 'seed and soil' theory, which may have guiding significance for selection of chemotherapy regimens. Therefore, a high TSR be new risk recurrence in patients stage II colorectal cancer (CRC). present study aimed to evaluate prognostic value CRC, especially computer-calculated TSR. A comprehensive literature retrieval was performed using PubMed, Web Science, Embase Cochrane...
Retrospective study.
Background: Disc degeneration (DD) is one of the common diseases worldwide, which deeply influences normal life and leads to excruciating pain. However, an effective treatment for DD still not identified. Method: The present study systemically examined effect melatonin on annulus fibrosus (AF) cells patients with DD. Results: Melatonin had promoting proliferation, inducing autophagy, suppressing apoptosis AF Moreover, contributed translation transcription autophagy-related protein ATG7...
A major problem in osteosarcoma treatment is cisplatin resistance. We have reported the anti-osteosarcoma effect of oleandrin; however, whether oleandrin sensitizes to unknown. investigated chemosensitization and potential mechanisms cells U-2OS, SaOS-2, MG-63. The median-effect analysis demonstrated that + exerted synergistic (U-2OS MG-63) or additive effects (SaOS-2), which were consistent with changes intracellular accumulation platinum (Pt) Pt-DNA adducts. Immunohistochemistry staining...
ZnO NPs enter into osteosarcoma cells <italic>via</italic> VPS34/dynamin 2 pathway and accumulated in mitochondria, initiating mitophagy subsequent apoptosis.
In our previous whole-genome sequencing study of 30 unrelated northern Chinese Han patients, we identified six single nucleotide polymorphisms (SNPs) in the interleukin 17 receptor C (IL17RC) and collagen type VI α1 chain (COL6A1) genes that were potentially associated with thoracic ossification posterior longitudinal ligament (T-OPLL). To determine whether these SNPs are susceptibility to T-OPLL population, performed a case-control association confirm specific susceptible loci expanded...
Our previous studies have reported the antitumor effect of oleandrin on osteosarcoma; however, its chemosensitizing in osteosarcoma treatment is still unknown. Therefore, we explored sensitizing effects to cisplatin and investigated potential mechanisms. After exposure and/or cisplatin, CCK-8 colony formation assays, DAPI staining flow cytometry were performed detect cell proliferation apoptosis 143B, U-2OS MG-63 cells. The median-effect analysis was applied evaluate combined effect. Western...
The oncogenetic function of inhibitory member the apoptosis stimulating protein p53 family (iASPP) in chordoma is unclear and remains to elucidate. expression iASPP tissues cells, its correlation clinicopathological parameters effect on patients' prognosis were evaluated. Cellular proliferation, invasion cisplatin-response observed after knockdown or overexpression vitro. Co-Immunoprecipitation assay was used explore interaction between p53. regulation miRNA-124 apoptotic explored...
Ossification of the posterior longitudinal ligament (OPLL) is a myelopathy commonly observed in cervical spine. By contrast, thoracic OPLL (T‑OPLL) rare but more severe. Previous studies have identified several polymorphisms osteogenic genes that are associated with occurrence and development OPLL. However, few genetic evaluated T‑OPLL. The present study aimed to identify factors for by performing whole‑genome sequencing (WGS) 30 unrelated northern Chinese Han patients Using bioinformatics...
The thoracic ossification of the posterior longitudinal ligament (T‑OPLL) can cause spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous whole‑genome sequencing study first reported rs199772854 interleukin 17 receptor C (IL17RC) gene as a potentially pathogenic loci for T‑OPLL. aim present was to examine effects IL17RC rs199772854A site mutation on osteogenesis by establishing model osteogenic differentiation. wild‑type mouse embryonic osteoblast (3T3‑E1)...
Artificial bone materials are of high demand due to the frequent occurrence damage from trauma, disease, and ageing. Three-dimensional (3D) printing can tailor-make structures implants based on biomaterial inks, rendering personalized medicine possible. Herein, we extrusion-printed 3D silk fibroin (SF) scaffolds using mixed inks SF sodium alginate (SA), post-mineralized various calcium phosphates make hybrid scaffolds. The effects conditions mineralization mechanical properties were...
Thoracic ossification of the posterior longitudinal ligament (T-OPLL) can cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. The etiology T-OPLL is unknown condition difficult to treat surgically. Whole-genome sequencing identified a genetic variant at rs199772854 interleukin 17 receptor C (IL17RC) gene as potentially pathogenic locus associated with T-OPLL. We aimed determine whether rs199772854A site mutation causes abnormal expression IL17RC Han...
To develop a biodegradable implantable bone material with compatible mechanics the tissue, providing new biomaterial for clinical repair and regeneration.
The aim of this study was to illustrate the role long non-coding RNA (lncRNA) DLEU1 in regulating malignant progression clear cell renal carcinoma (ccRCC) by targeting microRNA-194-5p (miRNA-194-5p).DLEU1 expression level ccRCC tissues and para-cancerous determined quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). correlation between pathological indexes patients assessed. After silence DLUE1, proliferative migratory abilities ACHN 786-O cells were evaluated. Furthermore,...