A5100390110- Cervical and Thoracic Myelopathy
- Heterotopic Ossification and Related Conditions
- Spine and Intervertebral Disc Pathology
- Endometriosis Research and Treatment
- Magnesium Alloys: Properties and Applications
- Hepatitis B Virus Studies
- Intensive Care Unit Cognitive Disorders
- Infectious Diseases and Tuberculosis
- Wnt/β-catenin signaling in development and cancer
- Spinal Cord Injury Research
- Pancreatic and Hepatic Oncology Research
- Orthopedic Infections and Treatments
- Pain Mechanisms and Treatments
- Kruppel-like factors research
- Liver Disease Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Eosinophilic Disorders and Syndromes
- NF-κB Signaling Pathways
- Plant Pathogenic Bacteria Studies
- Orthopaedic implants and arthroplasty
- Spinal Fractures and Fixation Techniques
- Hereditary Neurological Disorders
- Immune Response and Inflammation
- Plant-Microbe Interactions and Immunity
Peking University Third Hospital
2010-2020
Peking University
2010-2020
Guangxi Medical University
2018
Guangdong Medical College
2018
Yangzhou University
2018
First Affiliated Hospital of GuangXi Medical University
2018
University of Arizona
2001
Summary Three genes that contribute to the ability of fungus Nectria haematococca cause disease on pea plants have been identified. These pathogenicity ( PEP ) are within 25 kb each other and located a supernumerary chromosome. Altogether, gene cluster contains six transcriptional units expressed during infection tissue. The biochemical function only one is known with certainty. This gene, PDA1 , encodes specific cytochrome P450 confers resistance pisatin, an antibiotic produced by plants....
Abstract Ossification of the posterior longitudinal ligament spine (OPLL), which is characterized by ectopic bone formation in spinal ligaments, can cause spinal-cord compression. To date, at least 11 susceptibility genes have been genetically linked to OPLL. In order identify potential deleterious alleles these OPLL-associated genes, we designed a capture array encompassing all coding regions target for next-generation sequencing (NGS) cohort 55 unrelated patients with By bioinformatics...
The aim of this investigation was to identify candidate single nucleotide polymorphisms (SNPs) and molecular pathways associated with tumor protein p53 (TP53) expression status in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), clarify their potential mechanisms, generate SNP-to-gene pathway hypothesis.Identify Causal SNPs Pathways (ICSNPathway) used perform analysis based on the results our previous genome-wide association study TP53 387 HBV-related HCC patients.Through...
Ossification of the posterior longitudinal ligament (OPLL) spine is a complex, multifactorial disease. Although several genes that are linked to cervical OPLL susceptibility have been reported, specific genetic studies regarding thoracic lacking. Whole-genome sequencing has considered as an efficient strategy search for disease-causing genes.We analysed whole-genome sequences in cohort 25 unrelated patients with OPLL. Bioinformatics analysis and various algorithms were used predict...
The reactivity enhancement of pain sensitive neurons in the nervous system is a feature pathogenesis for neuropathic (NP), yet underlying mechanisms need to be fully understood. In this study, we made an attempt clarify NP-related hub genes and signaling pathways so as provide effective diagnostic therapeutic methods toward NP.Microarray expression profile GSE30691 including mRNA-seq data spared nerve injury (SNI)-induced NP rats was accessed from GEO database. Then, associated with...
The thoracic ossification of the posterior longitudinal ligament (T‑OPLL) can cause spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous whole‑genome sequencing study first reported rs199772854 interleukin 17 receptor C (IL17RC) gene as a potentially pathogenic loci for T‑OPLL. aim present was to examine effects IL17RC rs199772854A site mutation on osteogenesis by establishing model osteogenic differentiation. wild‑type mouse embryonic osteoblast (3T3‑E1)...
Abstract Background Lumbar spinal stenosis (LSS) is one of the most frequent indications for spine surgery. Open decompression and fusion surgery was common treatment used to be regarded as golden standard LSS. In recent years, percutaneous endoscopic also However, effectiveness safety in LSS have not been supported by high-level evidence. Our aim 1) compare open 2) Investigate prognosis risk factors 3) Evaluate influence stability operative level, degeneration adjacent level. Methods It’s a...
Abstract Background Thoracic ossification of the posterior longitudinal ligament (T-OPLL) is one common factors that cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous study first reported rs201153092A site mutation collagen 6A1 ( COL6A1 ) gene as a potentially pathogenic locus for T-OPLL. We aimed to determine whether causes abnormal expression Han Chinese patients with T-OPLL this also associated cervical-OPLL. Methods Peripheral blood...
Thoracic ossification of the posterior longitudinal ligament (T-OPLL) can cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. The etiology T-OPLL is unknown condition difficult to treat surgically. Whole-genome sequencing identified a genetic variant at rs199772854 interleukin 17 receptor C (IL17RC) gene as potentially pathogenic locus associated with T-OPLL. We aimed determine whether rs199772854A site mutation causes abnormal expression IL17RC Han...
Thoracic ossification of the posterior longitudinal ligament (T‑OPLL) is one most common factors that causes thoracic spinal stenosis, resulting in intractable myelopathy and radiculopathy. Our previous study reported rs201153092 polymorphism present collagen 6A1 (COL6A1) gene was a potentially pathogenic locus for development T‑OPLL. The aimed to determine whether mutation abnormal expression COL6A1 Han Chinese patients with T‑OPLL, examine effects this on osteogenesis by establishing model...