A5004094694- Bone Tissue Engineering Materials
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advanced Nanomaterials in Catalysis
- Synthesis and properties of polymers
- biodegradable polymer synthesis and properties
- Advanced Photocatalysis Techniques
- Silicone and Siloxane Chemistry
- Advanced Sensor and Energy Harvesting Materials
- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- Magnesium Alloys: Properties and Applications
- Micro and Nano Robotics
- Advancements in Battery Materials
- Orthopaedic implants and arthroplasty
- Metal-Organic Frameworks: Synthesis and Applications
- Electrospun Nanofibers in Biomedical Applications
- Epoxy Resin Curing Processes
- Electrochemical sensors and biosensors
- Nanoparticles: synthesis and applications
- Hydrogels: synthesis, properties, applications
- Polymer Nanocomposites and Properties
- Bone Metabolism and Diseases
- Polymer Nanocomposite Synthesis and Irradiation
- Nanomaterials and Printing Technologies
Peking University Shenzhen Hospital
2021-2024
University of Hong Kong - Shenzhen Hospital
2017-2024
Hong Kong University of Science and Technology
2023-2024
University of Hong Kong
2013-2023
Chinese University of Hong Kong
2015-2023
First Affiliated Hospital Zhejiang University
2021-2023
Washington University in St. Louis
2021-2023
Zhejiang University
2021-2023
Orthopaedic Research
2021
Northeast Forestry University
2017-2018
Abstract Despite the widespread observations on osteogenic effects of magnesium ion (Mg 2+ ), diverse roles Mg during bone healing have not been systematically dissected. Here, we reveal a previously unknown, biphasic mode action in repair. During early inflammation phase, contributes to an upregulated expression transient receptor potential cation channel member 7 (TRPM7), and TRPM7-dependent influx monocyte-macrophage lineage, resulting cleavage nuclear accumulation TRPM7-cleaved kinase...
In this work, a biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing wound-healing performances was synthesized. Through an in situ reduction reaction, PCN-222 metal organic framework (MOF) doped bismuth nanoparticles (Bi NPs) to form Bi-PCN-222, interfacial Schottky heterojunction catalyst, which can kill 99.9% of Staphylococcus aureus (S. aureus). The underlying mechanism that Bi NP doping endow Bi-PCN-222 MOF self-driven charge transfer through the interface...
Osteosarcoma occurs in children and adolescents frequently leads to a high fatality rate. Although surgical resection is the most common methods clinic, patients always suffer from tumor metastasis recurrence it difficult for them self-repair large bone defects. Furthermore, postoperative infection bacteria triggers an inflammatory response hinders bone-repair process. This work demonstrates gadolinium (Gd)-complex molybdenum sulfide (MoS2 ) co-doped N-acryloyl glycinamide (NAGA)/gelatin...
The regeneration of critical-size bone defects, especially those with irregular shapes, remains a clinical challenge. Various biomaterials have been developed to enhance regeneration, but the limitations on shape-adaptive capacity, complexity operation, and unsatisfied osteogenic bioactivity greatly restricted their application. In this work, we construct mechanically robust, tailorable water-responsive shape-memory silk fibroin/magnesium (SF/MgO) composite scaffold, which is able quickly...
Understanding cell-biomaterial interactions is critical for the control of cell fate tissue engineering and regenerative medicine. Here, cerium oxide nanoparticles (CeONPs) are applied at different Ce4+/Ce3+ ratios (i.e., 0.46, 1.23, 3.23) to titanium substrate surfaces by magnetron sputtering vacuum annealing. Evaluation cytotoxicity modified surface cultured rat bone marrow mesenchymal stem cells (BMSCs) reveals that cytocompatibility proliferation proportional increases in ratio on...
Antibacterial nanomaterials have attracted great interest in recent years, especially with an increase antibiotic resistance of microbial organisms. However, deleterious properties such as aggregation, toxicity nanoparticles, and low stability limit their practical application. In this respect, we developed novel PLA-based fibrous mats GO-Ag hybrid nanofillers through electrospinning for minimizing bacterial attachment growth biomedical applications. Polylactic acid (PLA) exhibits tensile...
Bacterial infections are a serious public health issue that threatens the lives of patients because their ability to induce other lethal complications without prompt treatment. Conventional antibiotic therapy can cause bacterial resistance and adverse effects. It is highly desirable develop effective antibiotic‐independent therapeutic strategies treat various kinds infections. Herein, sonodynamic‐enhanced piezoelectric materials MoS 2 Cu Oheterostructure responds exogenous ultrasound (US)...
By virtue of the unique magnetic properties and other functionalities, multifunctional nanoparticles (MNPs) are very promising in diagnostic therapeutic applications. This review summarizes recent developments pertaining to synthesis MNPs with focus on various surface modification strategies such as chemical synthesis, self-assembly, ligand exchange. Recent applications multimodal imaging including resonance (MRI)/optical (fluorescent dyes, quantum dots (QDs), near-infrared absorption...
Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections after orthopedic implant increase the risk of failure and potentially cause amputation limbs or life-threatening sepsis in severe cases. Additionally, satisfactory bone-implant integration is another important indicator an ideal implant. Here, antibiotic-free antibacterial nanofilm based on oxide perovskite-type calcium titanate (CTO)/fibrous red phosphorus (RP) titanium surface (Ti-CTO/RP) which P-N heterojunction...
Abstract Temperature variation‐induced thermoelectric catalytic efficiency of material is simultaneously restricted by its electrical conductivity, Seebeck coefficient, and thermal conductivity. Herein, Bi 2 Te 3 nanosheets are in situ grown on reduced graphene oxides (rGO) to generate an efficient photo‐thermoelectric catalyst (rGO‐Bi ). This system exhibits phonon scattering effect extra carrier transport channels induced the formed heterointerface between rGO , which improves power factor...
Deep tissue infection, such as osteomyelitis, caused by methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health and cannot be effectively treated antibiotics. In this study, we report microwave (MW)-responsive MoO2/WO3 heterojunction that can utilized treat MRSA-infected osteomyelitis under MW irradiation because of the enhanced thermal effect catalysis composite. The underlying mechanism is follows: A myriad oxygen vacancies forms on surface MoO2 WO3...
The healing of critical-sized bone defects (CSD) remains a challenge in orthopedic medicine. In recent years, scaffolds with sophisticated microstructures fabricated by the emerging three-dimensional (3D) printing technology have lighted up treatment CSD due to elaborate microenvironments and support they may build. Here, we established magnesium oxide-reinforced 3D-printed biocomposite scaffold investigate effect magnesium-enriched 3D microenvironment on repairing. composite was prepared...
The rapid development of sonodynamic therapy (SDT) provides a promising strategy for treating deep-seated multidrug-resistant (MDR) bacterial infection. However, the extreme scarcity biologically functional and highly efficient sonosensitizers severely limits further clinical practice SDT. Herein, lattice-strain-rich Ti3C2 (LS-Ti3C2) with greatly improved sonosensitizing effect is one-step synthesized using meso-tetra(4-carboxyphenyl)porphine (TCPP) by solvothermal method realizing...