A5100393521- Click Chemistry and Applications
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Spectroscopy and Quantum Chemical Studies
- Mast cells and histamine
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer-related Molecular Pathways
- Sleep and Wakefulness Research
- Lung Cancer Treatments and Mutations
- Advancements in Battery Materials
- Synthesis and biological activity
- Supramolecular Chemistry and Complexes
- Cell Adhesion Molecules Research
- MXene and MAX Phase Materials
- Porphyrin and Phthalocyanine Chemistry
- Advanced Chemical Physics Studies
- Advanced Biosensing Techniques and Applications
- Enhanced Oil Recovery Techniques
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Cellular Mechanics and Interactions
- Olfactory and Sensory Function Studies
- NMR spectroscopy and applications
- Ionic liquids properties and applications
- Cell death mechanisms and regulation
Karamay Central Hospital of Xinjiang
2024
Shandong University
2024
Changzhi University
2018-2022
Chinese Institute for Brain Research
2021-2022
Peking University
2021-2022
McGovern Institute for Brain Research
2021
King University
2021
Chongqing University
2017
Molecularly imprinted polymers (MIPs) are tailor-made materials with special binding sites.
The efficient synthesis of acyclonucleosides bearing coplanar 3-arylethynyltriazole motifs was established and several compounds displayed antiproliferative activity against cancer cells.
Focal adhesion kinase (FAK) is responsible for the development and progression of various malignancies. With aim to explore novel FAK inhibitors as anticancer agents, a series 2,4-dianilinopyrimidine derivatives 8a–8i 9a–9g containing 4-(morpholinomethyl)phenyl N-substituted benzamides have been designed synthesized. Among them, compound 8a displayed potent anti-FAK activity (IC50 = 0.047 ± 0.006 μM) selective antiproliferative effects against H1975 0.044 0.011 A431 cells 0.119 0.036 μM)....
Background: The third-generation irreversible Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) inhibit the T790M mutation while sparing EGFRWT. However, C797S point confers resistance to existing EGFRT790M inhibitors. Objective: Novel inhibitors were designed through hybridization of quinoline and anilinopyrimidine, biologically evaluated their antiproliferative activity against Non-Small Cell Lung Cancer (NSCLC) cell lines. Methods: target compounds 11a-h...
In recent years, metal coordination macrocycles have obtained great interests due to the fact that they combined rich host-guest properties of macro-cyclic hosts and unique optical organic ligands. this work, we constructed two porphyrin-based organoplatinum(II) metallacycles (MC1 MC2) through coordination-driven self-assembly. 1H NMR, 31P HRMS technologies were used characterize structures MC1 MC2. Interestingly, MC2 can be as catalysts for photooxidization under light irradiation with...
A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All the chalcone compounds tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, CRL-5908). The antiproliferative 3, 6, 9, 14, 15, 16 HCT116 cells was significantly better than that 5-Fluorouracil (IC50: 94.63 µM). these showed obvious differences between wild type mutant (TP53−/−) cells. preliminary mechanistic study suggested act by...
Abstract Histamine (HA) is a key biogenic monoamine involved in wide range of physiological and pathological processes both the central nervous system periphery. Because ability to directly measure extracellular HA real-time will provide important insights into functional role complex circuits under variety conditions, we developed series genetically encoded G protein-coupled r eceptor ctivation- b ased (GRAB) (GRAB ) sensors. These sensors produce robust increase fluorescence upon...
The Badaowan Formation in the Mahu Sag of Junggar Basin has revealed a low oil saturation reservoir with promising exploration prospects. To understand pore structure characteristics and their impact on content, high-pressure mercury injection nuclear magnetic resonance (NMR) experiments were used to identify classify structures. In previous studies, disparity NMR transverse relaxation time(T2) between centrifuged saturated samples frequently been utilized establish correlation capillary...
We here describe a fluorescent signal amplification method termed "Click-based amplification" that can be well integrated with various click-labelling modes, including chemical labelling, genetic incorporation and covalent inhibitor probe mediated target labelling. Picolyl azide (pAz) was used as functional group of streptavidin-based amplifier to enhance the efficiency click chemistry. Click-based provided 3.0-12.7 fold on fixed HeLa cells different modes. has proven superior tyramide (TSA)...