A5038991869- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
Center for Life Sciences
2023-2024
Peking University
2023-2024
Chinese Institute for Brain Research
2023-2024
Abstract As a central part of the mammalian brain, prefrontal cortex (PFC) has been implicated in regulating cocaine-induced behaviors including compulsive seeking and reinstatement. Although dysfunction PFC reported animal human users with chronic cocaine abuse, less is known about how involved behaviors. By using two-photon Ca 2+ imaging to simultaneously record tens intact individual networking neurons frontal association (FrA) awake male mice, here we report that systematic acute...
Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic phasic action potential (AP) firing patterns behavior mice. Besides AP numbers, whether how different per se modulate DA release remain largely unknown. Here by using vivo ex models, it shown that frequency modulates through D2 receptor (D2R), which contributes up to 50% of total release. D2R has a voltage-sensing site at D131 can be deactivated frequency-dependent...